Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Saul A. Rosenberg"'
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f852ee29a9488942fba6fce73ac0eaf
https://doi.org/10.1158/1535-7163.c.6543327.v1
https://doi.org/10.1158/1535-7163.c.6543327.v1
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
1. Measured pKa values of ABBV-167 (Table S1. Ionization constants of ABBV-167) 2. Preparation of ABBV-167 on large scale (Scheme S1: Synopsis of GMP synthesis of ABBV-167) 3. Preparation of clinical ABBV-167 drug supply 4. Animal pharmacokinetics (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82ad084c554229baf59a8bada6e495
https://doi.org/10.1158/1535-7163.22522290
https://doi.org/10.1158/1535-7163.22522290
Autor:
Steven W. Elmore, Chris Tse, Joel D. Leverson, Deepak Sampath, Heather Maecker, Saul H. Rosenberg, Scott L. Ackler, Haichao Zhang, Stephen K. Tahir, Alexander R. Shoemaker, Yu Shen, Morey Smith, Xiaoyu Lin, Paul Nimmer, Michael J. Mitten, Bernard Liu, Xiaoli Huang, Vivek Abraham, Sha Jin, Jun Chen
PDF file - 40K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2c37b6b6dd801b591e2466ba9d48a4
https://doi.org/10.1158/1535-7163.22497208
https://doi.org/10.1158/1535-7163.22497208
Autor:
Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
Structures and PC3 viability IC50 data for compounds in Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f450290df0d613596edbab94a5a07a69
https://doi.org/10.1158/1535-7163.22503433.v1
https://doi.org/10.1158/1535-7163.22503433.v1
Autor:
Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
Supplementary methods, tables S1-S3, and supplementary figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e7619544c11452e1775f6d92101867
https://doi.org/10.1158/1535-7163.22503430.v1
https://doi.org/10.1158/1535-7163.22503430.v1
Autor:
Steven W. Elmore, Chris Tse, Joel D. Leverson, Deepak Sampath, Heather Maecker, Saul H. Rosenberg, Scott L. Ackler, Haichao Zhang, Stephen K. Tahir, Alexander R. Shoemaker, Yu Shen, Morey Smith, Xiaoyu Lin, Paul Nimmer, Michael J. Mitten, Bernard Liu, Xiaoli Huang, Vivek Abraham, Sha Jin, Jun Chen
PDF file - 78K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cb83ab1dce91e1962e4cf133b54b8a
https://doi.org/10.1158/1535-7163.22497211
https://doi.org/10.1158/1535-7163.22497211
Autor:
Steven W. Elmore, Chris Tse, Joel D. Leverson, Deepak Sampath, Heather Maecker, Saul H. Rosenberg, Scott L. Ackler, Haichao Zhang, Stephen K. Tahir, Alexander R. Shoemaker, Yu Shen, Morey Smith, Xiaoyu Lin, Paul Nimmer, Michael J. Mitten, Bernard Liu, Xiaoli Huang, Vivek Abraham, Sha Jin, Jun Chen
PDF file - 77K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4246d1fdcd63851c0714efa3d05f46d0
https://doi.org/10.1158/1535-7163.22497205.v1
https://doi.org/10.1158/1535-7163.22497205.v1
Autor:
Yu Shen, Warren M. Kati, Keith F. McDaniel, Saul H. Rosenberg, Steven W. Elmore, Guowei Fang, Fred Kohlhapp, Xin Lu, Tamar Uziel, Lisa Hasvold, Dachun Liu, John K. Pratt, Steve Fidanze, Le Wang, George S. Sheppard, Cherrie K. Donawho, Denise Wilcox, Xiaoli Huang, Scott E. Warder, Emily J. Faivre, Lloyd T. Lam, Leiming Li, Daniel H. Albert, Xiaoyu Lin, Mai H. Bui
High level of concomitant Bim and Bcl-2 expression correlates with sensitivity to ABBV-075-induced apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909cb57dd24aaafd2fca2c7e82f7b5b3
https://doi.org/10.1158/0008-5472.22414799.v1
https://doi.org/10.1158/0008-5472.22414799.v1
Autor:
Yu Shen, Warren M. Kati, Keith F. McDaniel, Saul H. Rosenberg, Steven W. Elmore, Guowei Fang, Fred Kohlhapp, Xin Lu, Tamar Uziel, Lisa Hasvold, Dachun Liu, John K. Pratt, Steve Fidanze, Le Wang, George S. Sheppard, Cherrie K. Donawho, Denise Wilcox, Xiaoli Huang, Scott E. Warder, Emily J. Faivre, Lloyd T. Lam, Leiming Li, Daniel H. Albert, Xiaoyu Lin, Mai H. Bui
Apoptosis induction by MS417 across cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae3d2859044504ae5d9fac2647897bd
https://doi.org/10.1158/0008-5472.22414754.v1
https://doi.org/10.1158/0008-5472.22414754.v1
Autor:
Yu Shen, Warren M. Kati, Keith F. McDaniel, Saul H. Rosenberg, Steven W. Elmore, Guowei Fang, Fred Kohlhapp, Xin Lu, Tamar Uziel, Lisa Hasvold, Dachun Liu, John K. Pratt, Steve Fidanze, Le Wang, George S. Sheppard, Cherrie K. Donawho, Denise Wilcox, Xiaoli Huang, Scott E. Warder, Emily J. Faivre, Lloyd T. Lam, Leiming Li, Daniel H. Albert, Xiaoyu Lin, Mai H. Bui
Restoration of Myc expression under BET inhibitor treatment failed to rescue cells from apoptosis or cell cycle arrest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abe11b9198b4334433eaf466eccee57
https://doi.org/10.1158/0008-5472.22414802
https://doi.org/10.1158/0008-5472.22414802