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Akademický článek

Telomerase-pulsed dendritic cells: preclinical results and outcome of a clinical phase I/II trial in patients with metastatic renal cell carcinoma

Autor: Schmiedel, Alexandra, Sommer, Thorsten, Schild, Hans Heinz, Strunk, Holger, von Ruecker, Alexander, Franchy, Christian, Müller, Stefan, Albers, Peter, Sievers, Elisabeth, Märten, Angela, Sauerbruch, Tilman, Schmidt-Wolf, Ingo G.H.

Publikováno v: GMS German Medical Science, Vol 4, p Doc02 (2006)

Objective: Therapeutic vaccination with dendritic cells (DC) showed promising results in first clinical trials in cases of metastatic renal cell carcinoma (RCC). Human telomerase reverse transcriptase (hTERT) could be a potential target because it is

Externí odkaz: https://doaj.org/article/99f51663984046669710ba78ef69a428

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Akademický článek

TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

Autor: Körner Christian, Riesner Katarina, Krämer Benjamin, Eisenhardt Marianne, Glässner Andreas, Wolter Franziska, Berg Thomas, Müller Tobias, Sauerbruch Tilman, Nattermann Jacob, Spengler Ulrich, Nischalke Hans

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 85 (2012)

Abstract Background Tumour surveillance via induction of TRAIL-mediated apoptosis is a key mechanism, how the immune system prevents malignancy. To determine if gene variants in the TRAIL receptor I (DR4) gene affect the risk of hepatitis C virus (HC

Externí odkaz: https://doaj.org/article/49852ad541b040c9a76142f9494026f6

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Akademický článek

Feasibility and safety of long-term photodynamic therapy (PDT) in the palliative treatment of patients with hilar cholangiocarcinoma

Autor: Höblinger A, Gerhardt T, González-Carmona MA, Hüneburg R, Sauerbruch T, Schmitz V

Publikováno v: European Journal of Medical Research, Vol 16, Iss 9, p 391 (2011)

Abstract Background and Aim PDT is an important palliative option for patients with unresectable extrahepatic cholangiocarcinoma (CC). However, the results published to date reported on studies with no more than 6 (mostly up to 4) PDT procedures. Fur

Externí odkaz: https://doaj.org/article/ee4a14b9628248bbb60decebadb13b81

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Akademický článek

Progression of liver fibrosis in HIV/HCV genotype 1 co-infected patients is related to the T allele of the rsI2979860 polymorphism of the IL28B gene

Autor: Lutz P, Wasmuth J-C, Nischalke H-D, Vidovic N, Grünhagei F, Lammert F, Oldenburg J, Rockstroh JK, Sauerbruch T, Spcngler U

Publikováno v: European Journal of Medical Research, Vol 16, Iss 8, p 335 (2011)

Abstract Objective HIV/HCV co-infection is characterised by accelerated progression of liver disease. Recently, the rsl2979860 C/T polymorphism in the IL28B gene has been linked to progression towards cirrhosis in HCV mono-infected patients and to tr

Externí odkaz: https://doaj.org/article/c655d66319cc4cd9ac3bab4d1a5b49f9

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Akademický článek

Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence

Autor: Vogel M, Friedrich O, Lüchters G, Holleczek B, Wasmuth JC, Anadol E, Schwarze-Zander C, Nattermann J, Oldenburg J, Sauerbruch T, Rockstroh JK, Spengler U

Publikováno v: European Journal of Medical Research, Vol 16, Iss 3, p 101 (2011)

Abstract Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single c

Externí odkaz: https://doaj.org/article/5bda75227e834572b29bcb7af2df392c

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Akademický článek

Transient elastography discloses identical distribution of liver fibrosis in chronic hepatitis C between HIV-negative and HIV-positive patients on HAART

Autor: Grünhage F, Wasmuth J-C, Herkenrath S, Vidovic N, Goldmann G, Rockstroh J, Lammert F, Oldenburg J, Sauerbruch T, Spengler U

Publikováno v: European Journal of Medical Research, Vol 15, Iss 4, p 139 (2010)

Abstract Objective Progressive immunodeficiency associated with HIV-infection leads to a progressive course of liver disease in HIV/HCV-co-infected patients. Highly active antiretroviral therapy (HAART) efficiently restores and preserves immune funct

Externí odkaz: https://doaj.org/article/1efa24342fdf4d1298c971bdb5828e72

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Akademický článek

Renal impairment after liver transplantation - a pilot trial of calcineurin inhibitor-free vs. calcineurin inhibitor sparing immunosuppression in patients with mildly impaired renal function after liver transplantation

Autor: Gerhardt T, Terjung B, Knipper P, Palmedo H, Woitas RP, Kalff J, Sauerbruch T, Spengler U

Publikováno v: European Journal of Medical Research, Vol 14, Iss 5, p 210 (2009)

Abstract Objectives Chronic kidney disease is frequent in patients after orthotopic liver transplantation (OLT) and has impact on survival. Patients receiving calcineurin inhibitors (CNI) are at increased risk to develop impaired renal function. Earl

Externí odkaz: https://doaj.org/article/2534769fc8cf47fa8c7d3a106dc5fd22

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Akademický článek

Coinheritance of hereditary spherocytosis and reversibility of cirrhosis in a young female patient with hereditary hemochromatosis

Autor: Höblinger A, Erdmann C, Strassburg CP, Sauerbruch T, Lammert F

Publikováno v: European Journal of Medical Research, Vol 14, Iss 4, p 182 (2009)

Abstract Here we report a 33-years-old woman with hereditary spherocytosis and hemochromatosis due to homozygosity for the C282Y mutation of the HFE gene. The coinheritance of both conditions led to severe iron overload and liver cirrhosis at young a

Externí odkaz: https://doaj.org/article/f062aef3a4f64901b2535383da4f1196

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