Splice-specific lyn knockout mice reveal a dominant function of LynB in preventing autoimmunity

Autor: Will Swanson, Senevirathne Se, Myra G. Nunez, Tanya S. Freedman, Brian L. Ruis, Ben F Brian, Binstadt Ba, Branden S. Moriarity, Sauer Ml, Auger Jl, Clifford A. Lowell

The unique roles of the Src-family kinases LynA and LynB in immune activating and inhibitory signaling have eluded definition. Here we report that LynB, the shorter splice product of lyn, carries the dominant immunosuppressive function. We used CRISP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf903a9d59a6a1bfce9fae9d3c437179
https://doi.org/10.1101/2021.05.03.439514

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A dominant function of LynB kinase in preventing autoimmunity.

Autor: Brian BF 4th; Graduate Program in Molecular Pharmacology and Therapeutics, University of Minnesota, Minneapolis, MN 55455, USA., Sauer ML; Graduate Program in Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Greene JT; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA., Senevirathne SE; Graduate Program in Molecular Pharmacology and Therapeutics, University of Minnesota, Minneapolis, MN 55455, USA., Lindstedt AJ; Graduate Program in Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, MN 55455, USA.; Medical Scientist Training Program, University of Minnesota, Minneapolis, MN 55455, USA., Funk OL; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA., Ruis BL; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Ramirez LA; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA., Auger JL; Department of Pediatrics, Division of Rheumatology, Allergy and Immunology, University of Minnesota, Minneapolis, MN 55455, USA., Swanson WL; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA., Nunez MG; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA., Moriarity BS; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA.; Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA., Lowell CA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Binstadt BA; Department of Pediatrics, Division of Rheumatology, Allergy and Immunology, University of Minnesota, Minneapolis, MN 55455, USA.; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA., Freedman TS; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.; Center for Autoimmune Diseases Research, University of Minnesota, Minneapolis, MN 55455, USA.

Publikováno v: Science advances [Sci Adv] 2022 Apr 22; Vol. 8 (16), pp. eabj5227. Date of Electronic Publication: 2022 Apr 22.

Zinc protection of fertilized eggs is an ancient feature of sexual reproduction in animals.

Autor: Wozniak KL; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Bainbridge RE; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Summerville DW; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Tembo M; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Phelps WA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Sauer ML; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Wisner BW; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Czekalski ME; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Pasumarthy S; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Hanson ML; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Linderman MB; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Luu CH; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Boehm ME; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Sanders SM; Department of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, and Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, United States of America., Buckley KM; Department of Biological Sciences, Auburn University, Auburn, Alabama, United States of America., Bain DJ; Department of Geology and Environmental Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Nicotra ML; Department of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, and Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, United States of America., Lee MT; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Carlson AE; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2020 Jul 31; Vol. 18 (7), pp. e3000811. Date of Electronic Publication: 2020 Jul 31 (Print Publication: 2020).