Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity

Autor: Ghosh, A, Dogan, Y, Moroz, M, Holland, Am, Yim, Nl, Rao, Uk, Young, Lf, Tannenbaum, D, Masih, D, Velardi, Enrico, Tsai, Jj, Jenq, Rr, Penack, O, Hanash, Am, Smith, Om, Piersanti, K, Lezcano, C, Murphy, Gf, Liu, C, Palomba, Ml, Sauer, Mg, Sadelain, M, Ponomarev, V, van den Brink, M. R.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3982::d9a007ec8ac226c2111eac50479410ab
http://hdl.handle.net/11391/1213306

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Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype β-thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial.

Autor: Kwiatkowski JL; Division of Hematology, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: kwiatkowski@chop.edu., Walters MC; University of California San Francisco Benioff Children's Hospital, Oakland, CA, USA., Hongeng S; Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Yannaki E; Gene and Cell Therapy Center of the Hematology Dept and Hematopoietic Cell Transplantation Unit, George Papanicolaou Hospital, Thessaloniki, Greece., Kulozik AE; Department of Paediatric Oncology, Haematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany; Hopp Children's Cancer Centre, Heidelberg, Germany; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, University of Heidelberg, Heidelberg, Germany; Clinical Co-operation Unit, Paediatric Leukaemia, DKFZ, and Medical Faculty, University of Heidelberg, Heidelberg, Germany., Kunz JB; Department of Paediatric Oncology, Haematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany; Hopp Children's Cancer Centre, Heidelberg, Germany., Sauer MG; Department of Pediatric Hematology and Oncology and Blood Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Thrasher AJ; UCL Great Ormond Street Institute of Child Health, Great Ormond Street Hospital NHS Trust, London, UK., Thuret I; Department of Pediatric Hematology and Oncology, Rare Disease Center for Thalassemia, Hôpital de la Timone, Marseille, France., Lal A; University of California San Francisco Benioff Children's Hospital, Oakland, CA, USA., Tao G; Bluebird Bio, Somerville, MA, USA., Ali S; Bluebird Bio, Somerville, MA, USA., Thakar HL; Bluebird Bio, Somerville, MA, USA., Elliot H; Bluebird Bio, Somerville, MA, USA., Lodaya A; Bluebird Bio, Somerville, MA, USA., Lee J; Bluebird Bio, Somerville, MA, USA., Colvin RA; Bluebird Bio, Somerville, MA, USA., Locatelli F; IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy., Thompson AA; Division of Hematology, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: Lancet (London, England) [Lancet] 2024 Nov 08. Date of Electronic Publication: 2024 Nov 08.

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.

Autor: Bonifacius A; Institute of Transfusion Medicine and Transplant Engineering., Lamottke B; Department of Pediatric Hematology and Oncology., Tischer-Zimmermann S; Institute of Transfusion Medicine and Transplant Engineering., Schultze-Florey R; Department of Pediatric Hematology and Oncology., Goudeva L; Institute of Transfusion Medicine and Transplant Engineering., Heuft HG; Institute of Transfusion Medicine and Transplant Engineering., Arseniev L; Cellular Therapy Centre, and., Beier R; Department of Pediatric Hematology and Oncology., Beutel G; Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Cario G; Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany., Fröhlich B; Pediatric Hematology and Oncology, Klinik für Kinder- und Jugendmedizin, University Children's Hospital Muenster, Münster, Germany., Greil J; University Children's Hospital Heidelberg, Heidelberg, Germany., Hansmann L; Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Hasenkamp J; Clinic for Hematology and Oncology, University Medicine Göttingen, Georg August University, Göttingen, Germany., Höfs M; Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital Essen, Essen, Germany., Hundsdoerfer P; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Jost E; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, University Medical Center RWTH Aachen, and Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Kafa K; Department of Pediatrics I, Martin Luther University Halle-Wittenberg, Halle, Germany., Kriege O; Third Department of Medicine-Haematology, Internal Oncology, and Pneumology, Johannes Gutenberg University Medical Center, Mainz, Germany., Kröger N; Department for Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany., Mathas S; Charité-Universitätsmedizin Berlin, Hematology, Oncology, and Tumor Immunology, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Group Biology of Malignant Lymphomas, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a cooperation between the MDC and the Charité, Berlin, Germany., Meisel R; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Nathrath M; Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany, and Children's Cancer Research Center and Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Putkonen M; Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland., Ravens S; Institute of Immunology, Hannover Medical School, Hannover, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany., Sala E; Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany., Sauer MG; Department of Pediatric Hematology and Oncology., Schmitt C; Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Schroers R; Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital, Bochum, Germany., Steckel NK; Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany., Trappe RU; German Posttransplant Lymphoproliferative Disease (PTLD) Study Group, Department of Internal Medicine II-Hematology and Oncology, Evangelisches Diakonie-Krankenhaus, Bremen, Germany., Verbeek M; Clinic and Policlinic for Internal Medicine III, School of Medicine, Technische Universität München, Klinikum rechts der Isar, Munich, Germany., Wolff D; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Blasczyk R; Institute of Transfusion Medicine and Transplant Engineering., Eiz-Vesper B; Institute of Transfusion Medicine and Transplant Engineering.; German Center for Infection Research (DZIF), Braunschweig, Germany., Maecker-Kolhoff B; Department of Pediatric Hematology and Oncology.; German Center for Infection Research (DZIF), Braunschweig, Germany.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Jun 15; Vol. 133 (12). Date of Electronic Publication: 2023 Jun 15.

Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial.

Autor: Eichinger A; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU, Munich, Germany., Poetschger U; Children's Cancer Research Institute, Vienna, Austria., Glogova E; Children's Cancer Research Institute, Vienna, Austria., Bader P; Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany., Basu O; Department of Pediatrics III, University Hospital Essen, University Medicine Essen, Essen, Germany., Beier R; Department of Pediatric Oncology and Hematology, Medizinische Hochschule Hannover, Hannover, Germany., Burkhardt B; Pediatric Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Classen CF; Oncology and Hematology Unit, Children's Hospital, University Medicine Rostock, Rostock, Germany., Claviez A; Department of Pediatrics and Bone Marrow Transplant Unit, Medical University of Schleswig-Holstein, Campus Kiel, Kiel, Germany., Corbacioglu S; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany., Deubzer HE; Department of Pediatric Hematology and Oncology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Berlin, Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany., Greil J; Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany., Gruhn B; Department of Pediatrics, Jena University Hospital, Jena, Germany., Güngör T; Department of Hematology/Oncology/Immunology, Gene-therapy, and Stem Cell Transplantation, University Children's Hospital Zurich - Eleonore Foundation & Children's Research Center (CRC), Zurich, Switzerland., Kafa K; Department of Pediatrics, University of Halle, Halle, Germany., Kühl JS; Department of Pediatric Oncology, Hematology and Hemostaseology, University of Leipzig, Leipzig, Germany., Lang P; University Children's Hospital, Tübingen, Germany., Lange BS; Department of Pediatrics, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany., Meisel R; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Müller I; Divison of Pediatric Stem Cell Transplantation and Immunology, Clinic for Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sauer MG; Department of Pediatric Oncology and Hematology, Medizinische Hochschule Hannover, Hannover, Germany., Schlegel PG; Department of Pediatric Hematology and Oncology, University Children's Hospital Würzburg, Würzburg, Germany., Schulz A; Department of Pediatrics, University Medical Center Ulm, Ulm, Germany., Stachel D; Children's Hospital, Universitätsklinikum Erlangen, Erlangen, Germany., Strahm B; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Wawer A; Department of Pediatrics and Children's Cancer Research Center, Kinderklinik München Schwabing, Technical University of Munich School for Medicine, Munich, Germany., Peters C; St. Anna Children's Hospital, University Vienna, St. Anna Children's Cancer Research Institute, Vienna, Austria., Albert MH; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU, Munich, Germany. michael.albert@med.lmu.de.

Publikováno v: Leukemia [Leukemia] 2022 Nov; Vol. 36 (11), pp. 2567-2576. Date of Electronic Publication: 2022 Sep 12.