Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities.

Autor: Vohidov F; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Andersen JN; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Economides KD; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Shipitsin MV; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Burenkova O; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Ackley JC; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Vangamudi B; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Nguyen HV; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Gallagher NM; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Shieh P; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Golder MR; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Liu J; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Dahlberg WK; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Ehrlich DJC; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Kim J; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Kristufek SL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Huh SJ; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Neenan AM; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Baddour J; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Paramasivan S; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., de Stanchina E; Memorial Sloan Kettering Cancer Center, 417 E 68th St, New York, New York 10065, United States., Kc G; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Turnquist DJ; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Saucier-Sawyer JK; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Kopesky PW; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Brady SW; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Jessel MJ; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Reiter LA; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Chickering DE; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Johnson JA; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Blume-Jensen P; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2021 Mar 31; Vol. 143 (12), pp. 4714-4724. Date of Electronic Publication: 2021 Mar 19.

Tailoring biomaterials for vaccine delivery.

Autor: Zhuo, Yanling¹ (AUTHOR), Zeng, Huanxuan² (AUTHOR), Su, Chunyu^1,3 (AUTHOR), Lv, Qizhuang^1,4,5 (AUTHOR) lvqizhuang062@163.com, Cheng, Tianyin⁴ (AUTHOR) hn5368@163.com, Lei, Lanjie³ (AUTHOR) leilanjie1988@163.com

Publikováno v: Journal of Nanobiotechnology. 8/12/2024, Vol. 22 Issue 1, p1-42. 42p.

Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs.

Autor: Golder MR; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu J; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; XTuit Pharmaceuticals, Waltham, MA, USA., Andersen JN; XTuit Pharmaceuticals, Waltham, MA, USA., Shipitsin MV; XTuit Pharmaceuticals, Waltham, MA, USA., Vohidov F; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Nguyen HV; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Ehrlich DC; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Huh SJ; XTuit Pharmaceuticals, Waltham, MA, USA., Vangamudi B; XTuit Pharmaceuticals, Waltham, MA, USA., Economides KD; XTuit Pharmaceuticals, Waltham, MA, USA., Neenan AM; XTuit Pharmaceuticals, Waltham, MA, USA., Ackley JC; XTuit Pharmaceuticals, Waltham, MA, USA., Baddour J; XTuit Pharmaceuticals, Waltham, MA, USA., Paramasivan S; XTuit Pharmaceuticals, Waltham, MA, USA., Brady SW; XTuit Pharmaceuticals, Waltham, MA, USA., Held EJ; XTuit Pharmaceuticals, Waltham, MA, USA., Reiter LA; XTuit Pharmaceuticals, Waltham, MA, USA., Saucier-Sawyer JK; XTuit Pharmaceuticals, Waltham, MA, USA., Kopesky PW; XTuit Pharmaceuticals, Waltham, MA, USA., Chickering DE; XTuit Pharmaceuticals, Waltham, MA, USA., Blume-Jensen P; XTuit Pharmaceuticals, Waltham, MA, USA. pblumejensen@xtuit.com.; Acrivon Therapeutics, Lab Central, Cambridge, MA, USA. pblumejensen@xtuit.com., Johnson JA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. jaj2109@mit.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2018 Nov; Vol. 2 (11), pp. 822-830. Date of Electronic Publication: 2018 Aug 20.

PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma.

Autor: Gaudin A; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA., Song E; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA., King AR; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA., Saucier-Sawyer JK; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA., Bindra R; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, 06511, USA., Desmaële D; Institut Galien Paris-Sud, UMR CNRS 8612, University Paris-Sud XI, Châtenay-Malabry, 92290, France., Couvreur P; Institut Galien Paris-Sud, UMR CNRS 8612, University Paris-Sud XI, Châtenay-Malabry, 92290, France., Saltzman WM; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA. Electronic address: mark.saltzman@yale.edu.

Publikováno v: Biomaterials [Biomaterials] 2016 Oct; Vol. 105, pp. 136-144. Date of Electronic Publication: 2016 Aug 04.

A holistic approach to targeting disease with polymeric nanoparticles.

Autor: Cheng CJ; 1] Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA. Present address: Alexion Pharmaceuticals, Cheshire, Connecticut 06410, USA. [2]., Tietjen GT; 1] Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA. [2]., Saucier-Sawyer JK; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA., Saltzman WM; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA.

Publikováno v: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2015 Apr; Vol. 14 (4), pp. 239-47. Date of Electronic Publication: 2015 Jan 19.