Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sau-Chi B. Yan"'
Autor:
Abigail L. Miller, Sau-Chi B. Yan, Karen Cichowski, Nelly Weledji, Bruce M. Konicek, Eric Legius, Ophélia Maertens, Rachel Ingraham, Jeremy R. Graff, Rebecca Lock
Neurofibromin 1-mutant (NF1-mutant) cancers are driven by excessive Ras signaling; however, there are currently no effective therapies for these or other Ras-dependent tumors. While combined MEK and mTORC1 suppression causes regression of NF1-deficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49010aee933dcfbbbfd85260a3c13af0
https://lirias.kuleuven.be/handle/123456789/541318
https://lirias.kuleuven.be/handle/123456789/541318
Autor:
Christophe C. Marchal, Irene Denning, Peter Edward Vaillancourt, Timothy R. Holzer, Jessica A. Roseberry Baker, Aaron M Gruver, Mark Wortinger, Jirong Lu, Julian Davies, Jeffrey C. Hanson, Sameera R. Wijayawardana, Ling Liu, Megan E Lacy, Andrew E. Schade, Hadrian P. Szpurka, Sau-Chi B. Yan, Joel D. Cook, Erin M Felke, Wei Zeng, Chi-Kin Chow, Emily Rhoads, Kelly M. Credille, Gregory Beuerlein
Publikováno v:
Histopathology. 65(6)
Development of novel targeted therapies directed against hepatocyte growth factor (HGF) or its receptor (MET) necessitates the availability of quality diagnostics to facilitate their safe and effective use. Limitations of some commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49e23889656e2ea7274884c9a15c640
https://pubmed.ncbi.nlm.nih.gov/25039923
https://pubmed.ncbi.nlm.nih.gov/25039923
Autor:
Sau-Chi B. Yan, Michael L. Denney, Valentine J. Klimkowski, Amy J. Smith, Lea M. Johnson, Michael Enrico Richett, Minsheng Zhang, Jefferson Ray Mccowan, Kumiko Takeuchi, Todd J. Kohn, Nickolay Y. Chirgadze, Jolie Anne Bastian, Dianna L. Bailey, Donetta S. Gifford-Moore, Barbara G. Utterback, Gerald F. Smith, Daniel Jon Sall, David K. Clawson, Richard Waltz Harper, David W. Snyder, Stephen L. Briggs, Ho-Shen Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:775-780
Potent, subnanomolar thrombin inhibitors 4, 5, and 6 are developed through side chain optimization of novel, benzo[b]thiophene-based small organic entities 2 and 3 and through SAR additivity studies of the new structural elements identified. X-ray cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe7d35a63ca810bf308f9e6a8bf352
https://doi.org/10.1016/s0960-894x(99)00074-8
https://doi.org/10.1016/s0960-894x(99)00074-8
Autor:
Nickolay Y. Chirgadze, Kenneth Lee Hauser, Ho-Shen Lin, Kenneth Jeff Thrasher, Stephen L. Briggs, Gerald F. Smith, Michael L. Denney, Sau-Chi B. Yan, Daniel Jon Sall, John A. Buben, K. Takeuchi, Donetta S. Gifford-Moore, Valentine J. Klimkowski, Jefferson Ray Mccowan, Barbara G. Utterback, David K. Clawson, Jolie Anne Bastian, Alan David Palkowitz, Minsheng Zhang, Richard Waltz Harper, Deborah D. Giera, Todd J. Kohn, Jennifer M. Tinsley
Publikováno v:
Journal of medicinal chemistry. 40(22)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e273868bb2a1580b5d2d0497e3331a9
https://pubmed.ncbi.nlm.nih.gov/9357512
https://pubmed.ncbi.nlm.nih.gov/9357512
Autor:
Jonathan Wendell Tetreault, Darryl Ballard, Ling Liu, Peter Edward Vaillancourt, Sau-Chi B. Yan, Wei Zeng, Mark Wortinger, Jinqi Xia, Jirong Lu, Ying Tang, Kelly M. Credille, Jennifer R. Stephens, Trish Brown-Augsburger, Chi-Kin Chow, Victoria L. Peek
Publikováno v:
Cancer Research. 73:5465-5465
MET is involved in many mechanisms of cancer proliferation and metastasis. Inappropriate activation of MET can be induced by HGF-independent mechanisms such as gene amplification, specific genetic mutations, and transcriptional up-regulation, or by H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b668b52ed319eba577a5550dae3be0e
https://doi.org/10.1158/1538-7445.am2013-5465
https://doi.org/10.1158/1538-7445.am2013-5465
Publikováno v:
Critical Care Medicine. 33:A147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c074ea97bd712577b9e17b127b7cb4c5
https://doi.org/10.1097/00003246-200512002-00520
https://doi.org/10.1097/00003246-200512002-00520
Publikováno v:
Neurochemical Research. 10:1-18
The soluble tubulin of human cerebral cortex, as assessed by [3H]colchicine binding of the 100,000 g supernatant fraction, decreases drastically with age, 75 percent from age 0 to age 90. There is also a considerably lower concentration of high molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27da1daf91364a4e95d7803546892e8a
https://doi.org/10.1007/bf00964768
https://doi.org/10.1007/bf00964768
Publikováno v:
Analytical biochemistry. 138(1)
Gel filtration studies on Sephadex G-75 demonstrate markedly increased elution volumes for proteins chromatographed with polyethylene glycol. As little as 5% ( w v ) polyethylene glycol in the applied protein sample can reduce apparent molecular weig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377e11731893dd4d7d6ac3c456f3ca99
https://pubmed.ncbi.nlm.nih.gov/6731837
https://pubmed.ncbi.nlm.nih.gov/6731837
Autor:
Donald J. Graves, Sau Chi B. Yan
Publikováno v:
Molecular and Cellular Biochemistry. 42
The catalytic subunit of phosphoprotein phosphatase (Mr = 35,000) is inactivated by phosphate compounds such as trimetaphosphate, PPi, and ATP. The inactivation of phosphoprotein phosphatase by these phosphate compounds is time- and concentration-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688b59f26b8ee4811a56a4277bf358a7
https://doi.org/10.1007/bf00223535
https://doi.org/10.1007/bf00223535