Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Satyawan B Jadhav"'
Autor:
Satyawan B. Jadhav, Benny M. Amore, Howard Bockbrader, Ryan L. Crass, Sunny Chapel, William J. Sasiela, Maurice G. Emery
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics.
Population pharmacokinetics (popPK) of bempedoic acid and the popPK/pharmacodynamic (popPK/PD) relationship between bempedoic acid concentrations and serum low-density lipoprotein cholesterol (LDL-C) from baseline were characterized. A two-compartmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6383b40066b4c6a0843ac2c52bd9fd91
https://doi.org/10.1007/s10928-023-09864-w
https://doi.org/10.1007/s10928-023-09864-w
Autor:
Gerald F. Watts, Satyawan B Jadhav, Sunny Chapel, Benny M. Amore, Alberico L. Catapano, P. Hugh R. Barrett, Ryan L Crass, Maurice G. Emery, Michael Kerschnitzki, William J. Sasiela
Publikováno v:
European Heart Journal - Cardiovascular Pharmacotherapy. 8:578-586
Aims Many patients are unable to achieve guideline-recommended LDL cholesterol (LDL-C) targets, despite taking maximally tolerated lipid-lowering therapy. Bempedoic acid, a competitive inhibitor of ATP citrate lyase, significantly lowers LDL-C with o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa82818bc1c931075bf655fc5640ac24
https://doi.org/10.1093/ehjcvp/pvab064
https://doi.org/10.1093/ehjcvp/pvab064
Autor:
Hartmut Derendorf, Michael B. Otteneder, Muzeeb Syed, Mohammad Ahsanul Akbar, Satyawan B. Jadhav, Vipada Khaowroongrueng, Michael Gertz, Matthias Fueth
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3061-3068
R7072 is a fully human monoclonal antibody (mAb) exerting anti-tumor activity via blockade of insulin like growth factor 1 receptor. The tumoral interstitial concentrations are anticipated to be better surrogates of active site concentrations than co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5992ce67ea4867ab1d3c50ec9310ec11
https://doi.org/10.1016/j.xphs.2021.03.022
https://doi.org/10.1016/j.xphs.2021.03.022
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3233-3242
Microdialysis is a validated and well-established technique for recovering and measurement of exogenous as well as endogenous small molecules in the interstitial spaces of various tissues. Microdialysis of large molecular weight compounds has become
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8e5b01ddad41c671e8d390dff179da
https://doi.org/10.1016/j.xphs.2016.08.016
https://doi.org/10.1016/j.xphs.2016.08.016
Autor:
Wolfgang F. Richter, Michael B. Otteneder, Matthias Fueth, Satyawan B. Jadhav, Vipada Khaowroongrueng, Hartmut Derendorf
Publikováno v:
Journal of pharmaceutical sciences. 106(9)
Therapeutic monoclonal antibodies (mAbs) exhibit limited distribution to the target tissues. Determination of target tissue interstitial concentration of mAbs is an important aspect in the assessment of their pharmacokinetic/pharmacodynamics relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfcd07ec25557c380d1c22a0aa5e1ab
https://pubmed.ncbi.nlm.nih.gov/28414146
https://pubmed.ncbi.nlm.nih.gov/28414146
Autor:
Sanjib Das, Rajendra L. Harde, Dnyaneshwar E. Shelke, Neelima Khairatkar-Joshi, Malini Bajpai, Ratika S. Sapalya, Harshada V. Surve, Girish S. Gudi, Rambabu Pattem, Dayanidhi B. Behera, Satyawan B. Jadhav, Abraham Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2073-2078
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-, ethyl- or propyl ether as PDE10A inhibitors. A number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60965152c23ed1f746f77808eb30258a
https://doi.org/10.1016/j.bmcl.2014.03.054
https://doi.org/10.1016/j.bmcl.2014.03.054
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E
Autor:
Nagarajan, Muthukaman, Macchindra, Tambe, Mahamadhanif, Shaikh, Dnyandeo, Pisal, Sanjay, Deshmukh, Shital, Tondlekar, Neelam, Sarode, Lakshminarayana, Narayana, Jitendra M, Gajera, Vidya G, Kattige, Srinivasa, Honnegowda, Vikas, Karande, Abhay, Kulkarni, Dayanidhi, Behera, Satyawan B, Jadhav, Girish S, Gudi, Neelima, Khairatkar-Joshi, Laxmikant A, Gharat
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(11)
A series of substituted tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives have been synthesized and their mPGES-1 biological activity has been disclosed in detail. Structure-activity relationship (SAR) optimization provided inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9874f5bf5efea64e8794baffe42a441c
https://pubmed.ncbi.nlm.nih.gov/28400234
https://pubmed.ncbi.nlm.nih.gov/28400234
Autor:
Satyawan B. Jadhav, Amelia N. Deitchman, Vipada Khaowroongrueng, Hartmut Derendorf, M. Tobias Heinrichs
Publikováno v:
The AAPS journal. 19(2)
Adequate drug penetration to a site of infection is absolutely imperative to ensure sufficient antimicrobial treatment. Microdialysis is a minimally invasive, versatile technique, which can be used to study the penetration of an antiinfective agent i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4617540cf22bcc1b3678f90cc31e9bdc
https://pubmed.ncbi.nlm.nih.gov/27943149
https://pubmed.ncbi.nlm.nih.gov/27943149
Autor:
Nagarajan, Muthukaman, Sanjay, Deshmukh, Neelam, Sarode, Shital, Tondlekar, Macchindra, Tambe, Dnyandeo, Pisal, Mahamadhanif, Shaikh, Vidya G, Kattige, Srinivasa, Honnegowda, Vikas, Karande, Abhay, Kulkarni, Satyawan B, Jadhav, Mahamad Yunnus A, Mahat, Girish S, Gudi, Neelima, Khairatkar-Joshi, Laxmikant A, Gharat
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(24)
The discovery and SAR of potent, selective dioxane-fused tricyclic benz[d]imidazole derivatives as mPGES-1 inhibitor are herein described. Various amide modifications in this series afforded many potent mPGES-1 inhibitors, of which 17d proved to be s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd13d730eff612038af486251a9056a6
https://pubmed.ncbi.nlm.nih.gov/27865703
https://pubmed.ncbi.nlm.nih.gov/27865703
Publikováno v:
Journal of Pharmacy and Pharmacology. 58:1451-1458
Statins, the widely used lipid-lowering drugs, are inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase, which catalyses a rate-limiting step in the biosynthesis of cholesterol. Many previous reports show that statins can act both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd58d2d3b84605f9636a515a1a35cba2
https://doi.org/10.1211/jpp.58.11.0005
https://doi.org/10.1211/jpp.58.11.0005