Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Satyawan, Jadhav"'
Autor:
Satyawan Jadhav, Sanjay Deshmukh, Siddharth Mhatre, Abhay Kulkarni, Shital Tondlekar, Samitabh Chakraborti, Nagarajan Muthukaman, Macchindra Tambe, Dnyandeo Pisal, Vikram Mansingh Bhosale, Neelam Sarode, Daisy Manish Shah, Mahamad Yunnus A. Mahat, Girish S. Gudi, Neelima Khairatkar-Joshi, Laxmikant Atmaram Gharat
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3766-3773
Endogenous nitrosothiols (SNOs) including S-nitrosoglutathione (GSNO) serve as reservoir for bioavailable nitric oxide (NO) and mediate NO-based signaling, inflammatory status and smooth muscle function in the lung. GSNOR inhibition increases pulmona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69f3548323ec6b3cb510c32ec44b9f3
https://doi.org/10.1016/j.bmcl.2018.10.012
https://doi.org/10.1016/j.bmcl.2018.10.012
Autor:
Vidya Ganapati Kattige, Srinivasa Honnegowda, Sanjay Deshmukh, Laxmikant Atmaram Gharat, Abhay Kulkarni, Neelam Sarode, Pooja Sawant, Shital Tondlekar, Neelima Khairatkar-Joshi, Vikas Karande, Dnyandeo Pisal, Satyawan Jadhav, Macchindra Tambe, Nagarajan Muthukaman, Mahamadhanif S. Shaikh, Ramchandra R. Sangana, Monali Pisat, Girish S. Gudi, Dayanidhi Behera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5131-5138
This letter describes the synthesis and biological evaluation of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as novel mPGES-1 inhibitors, capable of inhibiting an increased PGE2 production in the disease state. Structure-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c711ec94b372ec3592b14b193fefd59c
https://doi.org/10.1016/j.bmcl.2017.10.062
https://doi.org/10.1016/j.bmcl.2017.10.062
Autor:
Srinivasa Honnegowda, Shital Tondlekar, Dnyandeo Pisal, Abhay Kulkarni, Dayanidhi Behera, Girish S. Gudi, Laxmikant Atmaram Gharat, Macchindra Tambe, Nagarajan Muthukaman, Sanjay Deshmukh, Satyawan Jadhav, Jitendra Maganbhai Gajera, Neelam Sarode, Mahamadhanif S. Shaikh, Vikas Karande, Lakshminarayana Narayana, Vidya Ganapati Kattige, Neelima Khairatkar-Joshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2594-2601
A series of substituted tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives have been synthesized and their mPGES-1 biological activity has been disclosed in detail. Structure-activity relationship (SAR) optimization provided inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c3194769e93c1e5b342652115b63fe7
https://doi.org/10.1016/j.bmcl.2017.03.068
https://doi.org/10.1016/j.bmcl.2017.03.068
Autor:
Satyawan Jadhav, Mahamadhanif S. Shaikh, Abhay Kulkarni, Mahamad Yunnus A. Mahat, Nagarajan Muthukaman, Srinivasa Honnegowda, Vidya Ganapati Kattige, Laxmikant Atmaram Gharat, Vikas Karande, Shital Tondlekar, Dnyandeo Pisal, Macchindra Tambe, Neelima Khairatkar-Joshi, Girish S. Gudi, Neelam Sarode, Sanjay Deshmukh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5977-5984
The discovery and SAR of potent, selective dioxane-fused tricyclic benz[ d ]imidazole derivatives as mPGES-1 inhibitor are herein described. Various amide modifications in this series afforded many potent mPGES-1 inhibitors, of which 17d proved to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74aee3215b596ce6b0bc05c3c26d7a00
https://doi.org/10.1016/j.bmcl.2016.10.079
https://doi.org/10.1016/j.bmcl.2016.10.079
Autor:
Nagarajan Muthukaman, Pooja Sawant, Dnyandeo Pisal, Srinivasa Honnegowda, Abhay Kulkarni, Vidya Ganapati Kattige, Sanjay Deshmukh, Shital Tondlekar, Neelam Sarode, Satyawan Jadhav, Neelima Khairatkar-Joshi, Dayanidhi Behera, Girish S. Gudi, Ramchandra R. Sangana, Vikas Karande, Macchindra Tambe, Monali Pisat, Mahamadhanif S. Shaikh, Laxmikant Atmaram Gharat
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(7)
In an effort to identify CYP and hERG clean mPGES-1 inhibitors from the dihydrofuran-fused tricyclic benzo[d]imidazole series lead 7, an extensive structure-activity relationship (SAR) studies were performed. Optimization of A, D and E-rings in 7 aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa34d823475ba2b669394baf70bf1665
https://pubmed.ncbi.nlm.nih.gov/29519738
https://pubmed.ncbi.nlm.nih.gov/29519738
Autor:
Vijayshree B. Avhad, Rajendra L. Harde, Ashwini A. Joshi, Megha Marathe, Malini Bajpai, Satyawan Jadhav, Mahamad Yunnus A. Mahat, Praveen Kumar Gupta, Sanjib Das, Neelima Khairatkar-Joshi, Maulik Nitinkumar Gandhi, Girish S. Gudi, Deepak K. Bhateja, Srinivas Gullapalli, Shelke Dnyaneshwar Eknath, A. P. Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3238-3242
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-, ethyl- or propyl ether as PDE10A inhibitors. A number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a331b93cdbdc2cec527f194f2a9492
https://doi.org/10.1016/j.bmcl.2014.06.028
https://doi.org/10.1016/j.bmcl.2014.06.028
Autor:
Jason Manka, Hilde Lavreysen, Colleen M. Niswender, Jon Jacobs, M. Luz Martín-Martín, P. Jeffrey Conn, Meredith J. Noetzel, Han Min Tong, Elizabeth J. Herman, C. David Weaver, Chrysa Malosh, J. Scott Daniels, Susana Conde-Ceide, Paige N. Vinson, Shaun R. Stauffer, Gregor James Macdonald, Claire Mackie, José Manuel Bartolomé-Nebreda, Thomas Steckler, Silvia López, Craig W. Lindsley, Carrie K. Jones, Satyawan Jadhav, Mark Turlington
Publikováno v:
Journal of Medicinal Chemistry. 57:5620-5637
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec9e09891e97fb3e6b29c5a56f045fdf
https://doi.org/10.1021/jm500259z
https://doi.org/10.1021/jm500259z
Autor:
Colleen M. Niswender, Julie R. Field, Corey R. Hopkins, Darren W. Engers, Satyawan Jadhav, Jim Bogenpohl, Rocio Zamorano, Rocco D. Gogliotti, C. David Weaver, Analisa D. Thompson, Craig W. Lindsley, P. Jeffrey Conn, Carrie K. Jones, Ya Zhou, Yoland Smith, Anna L. Blobaum, Stacey R. Lindsley, J. Scott Daniels, Ryan D. Morrison
Publikováno v:
Journal of Medicinal Chemistry. 54:7639-7647
There is an increasing amount of literature data showing the positive effects on preclinical antiparkinsonian rodent models with selective positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4). However, most of the data generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dec8e3b3e5adcfec60502112350a2b45
https://doi.org/10.1021/jm200956q
https://doi.org/10.1021/jm200956q
Autor:
Jeffrey P. Lamb, Andrew S. Felts, P. Jeffrey Conn, Stacey R. Lindsley, Satyawan Jadhav, Kyle A. Emmitte, Craig W. Lindsley, Carrie K. Jones, Usha N. Menon, Alice L. Rodriguez
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4390-4394
Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu5 using a functional cell-based assay is described in this Letter. Further characterization of selected potent compounds in in vitro assays designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70619f41ac4cd25cd3fc5811bc72b7fa
https://doi.org/10.1016/j.bmcl.2010.06.064
https://doi.org/10.1016/j.bmcl.2010.06.064
Autor:
P. Jeffrey Conn, Satyawan Jadhav, Colleen M. Niswender, Jens Meiler, Craig W. Lindsley, Zixiu Xiang, Thomas M. Bridges, L. Michelle Lewis, Huiyong Yin, C. David Weaver, Carrie K. Jones, Alexander S. Kane, Eric S. Dawson, Evan P. Lebois, J. Phillip Kennedy
Publikováno v:
ACS Chemical Neuroscience. 1:104-121
Cholinergic transmission in the forebrain is mediated primarily by five subtypes of muscarinic acetylcholine receptors (mAChRs), termed M(1)-M(5). Of the mAChR subtypes, M(1) is among the most heavily expressed in regions that are critical for learni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20fb7d1a3598d95780e1633dc2358a9
https://doi.org/10.1021/cn900003h
https://doi.org/10.1021/cn900003h