Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Satyanarayana Valiveti"'
Publikováno v:
International Journal of Pharmaceutics. 346:10-16
Targeted delivery of a therapeutic agent into the hair and sebaceous follicles greatly depends on the extent of drug partitioning/diffusion in the sebum. The objective of the present research was to develop a method to determine the sebum partition c
Autor:
Peter A. Crooks, Kalpana S. Paudel, Audra L. Stinchcomb, Paul Kiptoo, Mohamed O. Hamad, Dana C. Hammell, Buchi N. Nalluri, Satyanarayana Valiveti
Publikováno v:
Journal of Pharmaceutical Sciences. 94:1965-1975
The aim of the present study was to evaluate the transdermal delivery of 6-beta-naltrexol (NTXOL), the active metabolite of naltrexone (NTX), across human skin and guinea pig skin in vitro and in hairless guinea pigs in vivo. NTXOL may be responsible
Autor:
Jianhong Chen, Kalpana S. Paudel, Dana C. Hammell, Satyanarayana Valiveti, Peter A. Crooks, Audra L. Stinchcomb, Mohamed O. Hamad
Publikováno v:
Pharmaceutical Research. 22:981-989
The purpose of this investigation was to evaluate the in vitro and in vivo percutaneous absorption of the following prodrugs of naltrexone (NTX): 2'-ethylbutyryl-3-O-ester-NTX (ETBUT-ester), methyl-3-O-carbonate-NTX (ME-carbonate), ethyl-3-O-carbamat
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 38:112-118
The aim of the present study was to develop a simple and sensitive LC-MS method for the estimation of delta8-tetrahydrocannabinol (delta8-THC) and its metabolite, 11-nor-delta8-tetrahydrocannabinol-9-carboxylic acid (11-nor-delta8-THC-9-COOH), in gui
Publikováno v:
Pharmaceutical Research. 21:1137-1145
The aim of the current investigation was to evaluate the percutaneous absorption of the synthetic cannabinoid WIN 55,212-2 in vitro and in vivo.The in vitro permeation studies of WIN 55,212-2 in human skin, hairless guinea pig skin, a polymer membran
Publikováno v:
Journal of Pharmaceutical Sciences. 93:1154-1164
The present study was carried out in order to develop a transdermal therapeutic system (TTS) for Δ8-THC. The in vitro permeability studies of Δ8-THC in human skin and hairless guinea pig skin with and without a rate-controlling membrane were conduc
Autor:
Satyanarayana Valiveti, Mitchell Klausner, Patrick Hayden, D. Caroline Earles, Audra L. Stinchcomb, Remigius U. Agu, Daniel P. Wermeling
Publikováno v:
Endocrine Research. 30:455-467
The aim of this study was to explore the nasal route as an alternative to daily subcutaneous injections of hPTH (1-34). Anesthetized rats were surgically prepared and nasally dosed with aqueous solutions of hPTH (1-34). Plasma samples were assayed by
Publikováno v:
International Journal of Pharmaceutical Investigation
Introduction: The majority of drugs obtained through synthesis and development show poor aqueous solubility and dissolution velocity, resulting in reduced bioavailability of drugs. Most of these problems arise from formulation-related performance iss
Autor:
Remigius U. Agu, Kalpana S. Paudel, Audra L. Stinchcomb, Dana C. Hammell, Satyanarayana Valiveti
Publikováno v:
Drug development and industrial pharmacy. 36(9)
The nonpsychoactive cannabinoid, cannabidiol (CBD), has great potential for the treatment of chronic and 'breakthrough' pain that may occur in certain conditions like cancer. To fulfill this goal, suitable noninvasive drug delivery systems need to be
Autor:
Satyanarayana Valiveti, Julie Spence, Lain-Yen Hu, Guang Wei Lu, Kimberly Jane Wade, Christine Zhuang, Lora C. Robosky, Ann Love, Matt Mollan, David L. Pole
Publikováno v:
International journal of pharmaceutics. 367(1-2)
To understand drug delivery to the sebum filled hair and sebaceous follicles, it is essential to use an artificial sebum as a surrogate of the human sebum for the investigation of drug transport properties. Artificial sebum L was developed in-house b