A rho GDP dissociation inhibitor produced by apoptotic T-cells inhibits growth of Mycobacterium tuberculosis.

Autor: Sambasivan Venkatasubramanian, Rohan Dhiman, Padmaja Paidipally, Satyanarayana S Cheekatla, Deepak Tripathi, Elwyn Welch, Amy R Tvinnereim, Brenda Jones, Dan Theodorescu, Peter F Barnes, Ramakrishna Vankayalapati

Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004617 (2015)

In this study, we found that a subpopulation of CD4(+)CD25(+) (85% Foxp3(+)) cells from persons with latent tuberculosis infection (LTBI) inhibits growth of M. tuberculosis (M. tb) in human monocyte-derived macrophages (MDMs). A soluble factor, Rho G

Externí odkaz: https://doaj.org/article/491a31ef392946ccaf136ad97d06270b

c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice

Autor: Ramakrishna Vankayalapati, Satyanarayana S. Cheekatla, Amy R. Tvinnereim, Rajesh Kumar Radhakrishnan, Ramya Sivangala Thandi, Padmaja Paidipally, Deepak Tripathi, Elwyn Welch

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports

CD4+CD25+FoxP3+ cells (Tregs) inhibit inflammatory immune responses to allografts. Here, we found that co-transplantation of allogeneic pancreatic islets with Tregs that are defective in c-Jun N-terminal kinase 1 (JNK1) signaling prolongs islet allog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6447929495f86e92c525016cbf388c
http://link.springer.com/article/10.1038/s41598-018-21477-9

Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.

Autor: Venkatasubramanian S; Department of Pulmonary Immunology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Tripathi D; Department of Pulmonary Immunology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Tucker T; Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Paidipally P; Department of Pulmonary Immunology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Cheekatla S; Department of Pulmonary Immunology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Welch E; Department of Pulmonary Immunology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Raghunath A; Department of Pulmonary Immunology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Jeffers A; Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Tvinnereim AR; Department of Pulmonary Immunology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Schechter ME; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Andrade BB; Investigative Medicine Branch, Laboratory of Immune Regulation, Centro de Pesquisas Gonçalo Moniz (CPqGM), Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.; Research Center, Brazilian Institute for Tuberculosis Research, Salvador, Bahia, Brazil., Mackman N; Department of Medicine, The University of North Carolina at Chapel Hill School of Medicine, NC, USA., Idell S; Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Vankayalapati R; Department of Pulmonary Immunology, University of Texas Health Science Center at Tyler, Tyler, TX, USA.

Publikováno v: European journal of immunology [Eur J Immunol] 2016 Feb; Vol. 46 (2), pp. 464-79. Date of Electronic Publication: 2015 Nov 10.