Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Satyajit Sujit Kumar Mitra"'
Autor:
Teodora Losic, Mary Do, Kim Tipton, Satyajit Sujit Kumar Mitra, Tony W. Liang, Jeffrey Kang, Sanjeev Satyal, Vasu Jammalamadaka, Greg Tuffy, William E. Haskins, William Monteith, Adriana Gamboa Lopez, Scott Savage, Melissa S. Jurica
Publikováno v:
Cancer Research. 81:1832-1832
Background: Thailanstatins are naturally occurring anti-proliferative compounds that target spliceosomes and modulate pre-mRNA splicing. Alterations in splicing machinery and mRNA splicing is common in cancer and represents a potential susceptibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce685867f4090e4d28b98b320ac762c
https://doi.org/10.1158/1538-7445.am2021-1832
https://doi.org/10.1158/1538-7445.am2021-1832
Autor:
Satyajit Sujit Kumar Mitra, Amy S. Lee, Shiuan Wey, Wenming Gao, Xiuqing Li, Yue Zhou, Peter S. Conti, Parkash S. Gill, Valery Krasnoperov, Ren Liu, Genyuan Zhu, Shuanglong Liu, Zibo Li, Dan Li, Dezheng Dong, Stan G. Louie
Publikováno v:
Clinical Cancer Research. 19:6802-6811
Purpose: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of the phosphoinositide 3-kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afc7e94810c7b208be48830f8be73bf
https://doi.org/10.1158/1078-0432.ccr-13-1106
https://doi.org/10.1158/1078-0432.ccr-13-1106
Autor:
Kellie Pickell, Andrew Lam, Lucas Donigan, Marcus Fischer, Satyajit Sujit Kumar Mitra, Fumiko Takada Axelrod, Hoang Tran, Aurélie Chaudhari, In-Kyung Park, Christopher J. Bond, Austin L. Gurney, Timothy Hoey, Sanjeev Satyal, Aaron K. Sato, John Lewicki, Jennifer Cain, Cecile Chartier, Michelle Stroud, Sasha Lazetic, Ann M. Kapoun, May Ji, Wan-Ching Yen, Shirley Ma
Publikováno v:
Proceedings of the National Academy of Sciences. 109:11717-11722
The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and several coreceptors, has long been implicated in cancer. Here we demonstrate a therapeutic approach to targeting the Wnt pathway with a monoclonal antibody, OMP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbc7ac0f527fa9ea201aeb1476036c3
https://doi.org/10.1073/pnas.1120068109
https://doi.org/10.1073/pnas.1120068109
Autor:
Honggang Yu, Alok Tomar, Dan A. Hanson, Ssang-Taek Lim, John Molina, Sean Uryu, Satyajit Sujit Kumar Mitra, Shihe Hou, David D. Schlaepfer, Yangmi Lim
Publikováno v:
Journal of Biological Chemistry. 282:17450-17459
Focal adhesion kinase (FAK) is a cytoplasmic protein-tyrosine kinase that promotes cell migration, survival, and gene expression. Here we show that FAK signaling is important for tumor necrosis factor-alpha (TNFalpha)-induced interleukin 6 (IL-6) mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527d5db8c1d9e131e156b7a362da3a1f
https://doi.org/10.1074/jbc.m610672200
https://doi.org/10.1074/jbc.m610672200
Publikováno v:
Current Opinion in Cell Biology. 18:516-523
Integrins can alter cellular behavior through the recruitment and activation of signaling proteins such as non-receptor tyrosine kinases including focal adhesion kinase (FAK) and c-Src that form a dual kinase complex. The FAK-Src complex binds to and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f706efab1042187dc5b5b471651dc1e2
https://doi.org/10.1016/j.ceb.2006.08.011
https://doi.org/10.1016/j.ceb.2006.08.011
Autor:
David A. Cheresh, Daniel A. Hanson, Aileen Chi, Dwayne G. Stupack, John Molina, Dusko Ilic, Joie A. Bernard-Trifilo, Lim St, David D. Schlaepfer, David Mikolon, Satyajit Sujit Kumar Mitra, Hsia Da
Publikováno v:
Oncogene. 25:5969-5984
Elevated focal adhesion kinase (FAK) expression occurs in advanced cancers, yet a signaling role for FAK in tumor progression remains undefined. Here, we suppressed FAK activity in 4T1 breast carcinoma cells resulting in reduced FAK Y925 phosphorylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb791cad1830b65fcffe8c328ab12887
https://doi.org/10.1038/sj.onc.1209588
https://doi.org/10.1038/sj.onc.1209588
Autor:
Datsun A. Hsia, Joie A. Bernard-Trifilo, Ssang-Taek Lim, Mark H. Ginsberg, Dusko Ilic, Sakae Tanaka, David D. Schlaepfer, Jeroen den Hertog, Daniel N. Streblow, Satyajit Sujit Kumar Mitra
Publikováno v:
Molecular and Cellular Biology. 25:9700-9712
The fibronectin binding integrins alpha5beta1 and alpha4beta1 generate signals pivotal for cell migration through distinct yet undefined mechanisms. For alpha5beta1, beta1-mediated activation of focal adhesion kinase (FAK) promotes c-Src recruitment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2139ebf7d1d8f0b08ff8a1a2040c7f19
https://doi.org/10.1128/mcb.25.21.9700-9712.2005
https://doi.org/10.1128/mcb.25.21.9700-9712.2005
Publikováno v:
Current Opinion in Genetics & Development. 14:92-101
The ability of intracellular signaling networks to orchestrate a complex biological response such as cell motility requires that individual signaling proteins must act as integrators, responding to multiple extracellular inputs and regulating multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7b7aa5ea96ce2082e6e2864fe756e6
https://doi.org/10.1016/j.gde.2003.12.002
https://doi.org/10.1016/j.gde.2003.12.002
Autor:
Daniel N. Streblow, Satyajit Sujit Kumar Mitra, David A. Cheresh, Christof R. Hauck, Jay A. Nelson, Jay Leng, David D. Schlaepfer, Kathryn S. R. Spencer, Datsun A. Hsia, Glen R. Nemerow, Dusko Ilic, Erguang Li, Shuang Huang
Publikováno v:
The Journal of Cell Biology
Cell migration and invasion are fundamental components of tumor cell metastasis. Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation are connected with elevated tumorigenesis. Null mutation of FAK results in embryonic lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0159394084aab770387f7a7d530dbf38
https://doi.org/10.1083/jcb.200212114
https://doi.org/10.1083/jcb.200212114
Publikováno v:
Experimental Cell Research. 270:32-44
PTP-S4/TC48 protein tyrosine phosphatase is localized in the nuclear and cytoplasmic membranes. To investigate the role of PTP-S4 in cell growth, adhesion, and transformation, normal and a catalytically inactive mutant form of this phosphatase were e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2eb14dc6c5ea4e292851b7500ae102a
https://doi.org/10.1006/excr.2001.5313
https://doi.org/10.1006/excr.2001.5313