Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Satya Kuchimanchi"'
Autor:
Linda L. Kusner, Kristina Yucius, Manjistha Sengupta, Andrew G. Sprague, Dhruv Desai, Tuyen Nguyen, Klaus Charisse, Satya Kuchimanchi, Rajeev Kallanthottathil, Kevin Fitzgerald, Henry J. Kaminski, Anna Borodovsky
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 484-492 (2019)
Complement-mediated damage to the neuromuscular junction (NMJ) is a key mechanism of pathology in myasthenia gravis (MG), and therapeutics inhibiting complement have shown evidence of efficacy in the treatment of MG. In this study, we describe the de
Externí odkaz:
https://doaj.org/article/44b70ce344d04d39ba586958c5169aed
Autor:
Amy Chan, Abigail Liebow, Makiko Yasuda, Lin Gan, Tim Racie, Martin Maier, Satya Kuchimanchi, Don Foster, Stuart Milstein, Klaus Charisse, Alfica Sehgal, Muthiah Manoharan, Rachel Meyers, Kevin Fitzgerald, Amy Simon, Robert J Desnick, William Querbes
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
The acute hepatic porphyrias are caused by inherited enzymatic deficiencies in the heme biosynthesis pathway. Induction of the first enzyme 5-aminolevulinic acid synthase 1 (ALAS1) by triggers such as fasting or drug exposure can lead to accumulation
Externí odkaz:
https://doaj.org/article/39568a2964f14544a20cb66549c751d3
Autor:
Molly Plovanich, Roman L Bogorad, Yasemin Sancak, Kimberli J Kamer, Laura Strittmatter, Andrew A Li, Hany S Girgis, Satya Kuchimanchi, Jack De Groot, Lauren Speciner, Nathan Taneja, Jonathan Oshea, Victor Koteliansky, Vamsi K Mootha
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55785 (2013)
Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a channel called the uniporter th
Externí odkaz:
https://doaj.org/article/a7337a4d9d914019b479cff21e32b7e5
Autor:
Tuyen Nguyen, Linda L. Kusner, Kristina Yucius, Anna Borodovsky, Henry J. Kaminski, Klaus Charisse, Kevin Fitzgerald, Rajeev G. Kallanthottathil, Dhruv Desai, Manjistha Sengupta, Andrew Sprague, Satya Kuchimanchi
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 484-492 (2019)
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 484-492 (2019)
Complement-mediated damage to the neuromuscular junction (NMJ) is a key mechanism of pathology in myasthenia gravis (MG), and therapeutics inhibiting complement have shown evidence of efficacy in the treatment of MG. In this study, we describe the de
Autor:
Scott Waldron, Satya Kuchimanchi, Scott A Barros, Maja M. Janas, Yongfeng Jiang, Mark K Schlegel
Publikováno v:
Nucleic Acid Therapeutics. 27:11-22
Single-stranded (ss) 2'-fluoro (2'-F)-modified oligonucleotides (ONs) with a full phosphorothioate (PS) backbone have been reported to be cytotoxic and cause DNA double-strand breaks (DSBs) when transfected into HeLa cells. However, the molecular det
Autor:
Hao Yin, Iris Zhuang, Hidenori Nonaka, Wen Xue, Carmen Barnes, Stephen Walsh, Satya Kuchimanchi, Vera M. Ruda, Daniel G. Anderson, Roman L. Bogorad, Lubomir Nechev, Marino Zerial, Robert Langer, Victor Koteliansky, Akin Akinc
Publikováno v:
Journal of Hepatology. 64:899-907
Background & Aims The Hippo pathway controls organ size through a negative regulation of the transcription co-activator Yap1. The overexpression of hyperactive mutant Yap1 or deletion of key components in the Hippo pathway leads to increased organ si
Autor:
Kun Qian, Kallanthottathil G. Rajeev, Casey Trapp, Martin Maier, Donald Foster, Muthiah Manoharan, Christopher R. Brown, Vasant Jadhav, Satya Kuchimanchi, Mark K Schlegel, Alfica Sehgal, Sarfraz Shaikh, Stuart Milstein
Publikováno v:
Molecular Therapy
Significant progress has been made in the advancement of RNAi therapeutics by combining a synthetic triantennary N-acetylgalactosamine ligand targeting the asialoglycoprotein receptor with chemically modified small interfering RNA (siRNA) designs, in
Autor:
Carlos Martinez, Thazha P. Prakash, Jiaxin Hu, Muthiah Manoharan, Walt F. Lima, Eric E. Swayze, Jing Liu, Qin Xiang, Jeremy G. Lackey, K. Jayaprakash Narayanannair, David R. Corey, Kallanthottathil G. Rajeev, Satya Kuchimanchi
Publikováno v:
Biochemistry
Dentatorubral-pallidoluysian atrophy (DRPLA) is a progressive neurodegenerative disorder that currently has no curative treatments. DRPLA is caused by an expansion of a CAG trinucleotide repeat region within the protein-encoding sequence of the atrop
Autor:
Sarfraz Shaikh, David R. Corey, Keith T. Gagnon, Satya Kuchimanchi, Masayuki Matsui, Huiying Zhang, Muthiah Manoharan, Yongjun Chu, Bethany A. Janowski
Publikováno v:
Nucleic Acids Research
Although many long non-coding RNAs (lncRNAs) have been discovered, their function and their association with RNAi factors in the nucleus have remained obscure. Here, we identify RNA transcripts that overlap the cyclooxygenase-2 (COX-2) promoter and c
Autor:
Jiaxin Hu, Jing Liu, K. Jayaprakash Narayanannair, Muthiah Manoharan, Hannah Pendergraff, Satya Kuchimanchi, David R. Corey, Jeremy G. Lackey, Kallanthottathil G. Rajeev
Publikováno v:
Nucleic Acids Research
Abasic substitutions within DNA or RNA are tools for evaluating the impact of absent nucleobases. Because of the importance of abasic sites in genetic damage, most research has involved DNA. Little information is available on the impact of abasic sub