Výsledky vyhledávání - "Satya K, Kota"

Akademický článek

Endogenous antisense RNA curbs CD39 expression in Crohn’s disease

Autor: Rasika P. Harshe, Anyan Xie, Marta Vuerich, Luiza Abrahão Frank, Barbora Gromova, Haohai Zhang, Rene’ J. Robles, Samiran Mukherjee, Eva Csizmadia, Efi Kokkotou, Adam S. Cheifetz, Alan C. Moss, Satya K. Kota, Simon C. Robson, Maria Serena Longhi

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

CD39 is an ectonucleotidase associated with immunoregulatory function. Here authors show regulation of CD39 expression by an endogenous antisense RNA moiety transcribed from the 3‘ end of CD39/ENTPD1 which when itself is silenced results in amelior

Externí odkaz: https://doaj.org/article/53270d85737b4225a98e857f58c20b7a

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Akademický článek

Elavl1 Impacts Osteogenic Differentiation and mRNA Levels of Genes Involved in ECM Organization

Autor: Satya K. Kota, Zhu Wei Lim, Savithri B. Kota

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Posttranscriptional gene regulation by Adenylate Uridylate (AU) rich element RNA binding protein, Elavl1 has been implicated in embryonic development as well as progenitor cell differentiation. Elavl1 binds to hundreds of cellular messenger RNAs pred

Externí odkaz: https://doaj.org/article/b189c60c1be040369adf399db3d12d1b

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Endogenous antisense RNA curbs CD39 expression in Crohn’s disease

Autor: Adam S. Cheifetz, Barbora Gromova, Haohai Zhang, Luiza Abrahão Frank, Maria Serena Longhi, Rasika P. Harshe, Simon C. Robson, Alan C. Moss, Satya K. Kota, Efi Kokkotou, Anyan Xie, Samiran Mukherjee, Eva Csizmadia, Rene’ J. Robles, Marta Vuerich

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications

CD39 is an ectonucleotidase that initiates conversion of extracellular nucleotides into immunosuppressive adenosine. CD39 is expressed by regulatory T (Treg)-cells, where it mediates immunosuppression, and by a subset of T-helper (Th) 17-cells, where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724f6e51636e9204f19653fb1ab9844f
https://doi.org/10.1038/s41467-020-19692-y

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Noncoding RNA and epigenetic gene regulation in renal diseases

Autor: Savithri B. Kota, Satya K. Kota

Publikováno v: Drug Discovery Today. 22:1112-1122

Kidneys have a major role in normal physiology and metabolic homeostasis. Loss or impairment of kidney function is a common occurrence in several metabolic disorders, including hypertension and diabetes. Chronic kidney disease (CKD) affect nearly 10%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ce33e543f61fd77993366fab4c6bcc
https://doi.org/10.1016/j.drudis.2017.04.020

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PRMT5 inhibition promotes osteogenic differentiation of mesenchymal stromal cells and represses basal interferon stimulated gene expression

Autor: Coco Roening, Nehal Patel, Savithri B. Kota, Roland Baron, Satya K. Kota

Publikováno v: Bone. 117

Protein arginine methyltransferases (PRMTs) catalyze symmetric and asymmetric methylation on arginine residues of multiple protein targets including histones and have essential roles in organismal development and disease. PRMT5 mediates symmetric di-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e732987398b7699cc183342af802c44e
https://pubmed.ncbi.nlm.nih.gov/30189247

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In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression

Autor: Vincent Demolombe, Robert Sabatier, Laurent Journot, Satya K. Kota, Chloé Maurizy, Philippe Arnaud, Stéphanie Rialle, Anne Le Digarcher, Stéphanie Maupetit-Mehouas, Emeric Dubois, Annie Varrault, Patricia Cavelier, Robert Feil, Mikael Pezet, Céline Meusnier, Christelle Reynes, Sabine Nidelet, Tristan Bouschet

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2017, 〈10.1093/cercor/bhw102〉
Cerebral Cortex, Oxford University Press (OUP), 2017, ⟨10.1093/cercor/bhw102⟩
Cerebral Cortex, Oxford University Press (OUP), 2016, 〈10.1093/cercor/bhw102〉
Cerebral Cortex, 2017, ⟨10.1093/cercor/bhw102⟩

International audience; In vitro corticogenesis from embryonic stem cells (ESCs) is an attractive model of cortical development and a promising tool for corticaltherapy. It is unknown to which extent epigenetic mechanisms crucial for cortex developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbc0dce06e9c2c5b544a04bbc53ae29
https://hal.archives-ouvertes.fr/hal-01934516

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Uncoupling of X-linked gene silencing from XIST binding by DICER1 and chromatin modulation on human inactive X chromosome

Autor: Venkata Padmalatha, Debabani Roy Chowdhury, Lalji Singh, Satya K. Kota, Lakshmi Rao, Utpal Bhadra

Publikováno v: Chromosoma. 124:249-262

In mammals, X-inactivation process is achieved by the cis-spreading of long noncoding Xist RNA over one of the female X chromosomes. The Xist binding accumulates histones H3 methylation and H4 hypoacetylation required for X inactivation that leads to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136a96f3d86d181d12e5c6707ae00088
https://doi.org/10.1007/s00412-014-0495-4

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BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI

Autor: Satya K. Kota, Isaac E. Stillman, David E. Leaf, Elizabeth Pernicone, Sushrut S. Waikar, Savithri B. Kota

Publikováno v: Journal of the American Society of Nephrology : JASN. 28(12)

AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d011cc7f7e288c2b46c077d3791e77
https://pubmed.ncbi.nlm.nih.gov/29951513

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Transcription and histone methylation changes correlate with imprint acquisition in male germ cells

Autor: Satya K. Kota, Karim Chebli, Amandine Henckel, Robert Feil, Philippe Arnaud

Publikováno v: The EMBO Journal. 31:606-615

Genomic imprinting in mammals is controlled by DNA methylation imprints that are acquired in the gametes, at essential sequence elements called 'imprinting control regions' (ICRs). What signals paternal imprint acquisition in male germ cells remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f95e407f08b32bcfcde6d7b37b8e5561
https://doi.org/10.1038/emboj.2011.425

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The Rejection Barrier to Induced Pluripotent Stem Cells

Autor: Satya K. Kota, Savithri Balasubramanian, M. Todd Valerius

Publikováno v: Journal of the American Society of Nephrology. 22:1583-1586

Tissue regeneration and organ development from patient-induced pluripotent stem cells (iPSCs), created through cellular reprogramming,[1][1],[2][2] are new approaches for resolving the inadequate number of organs available for transplantation, includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f88b0542ad41274cc23a10202b23efe
https://doi.org/10.1681/asn.2011070707

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