Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Satwant K. Narula"'
Autor:
Charles Wartchow, Julie DeMartino, David Robert Bolin, Gang Lu, Dan Li, Su Song, Chia Chi Sun, Lena Liang, Dinesh Srinivasan, Kuo-Sen Huang, Jaspreet Banga, Michelle Downing, Nader Fotouhi, Betsy J. Barnes, Cherrie D. Thompson, Hong Qian, Ann F. Hoffman, Seng-Lai Tan, Qin Guo, Yajuan Gu Qin, Jin Qiu, Francesca Milletti, Satwant K. Narula, Bharati Matta, Gang Chen, Margaret LaPan, Shannon Hamilton
Publikováno v:
Science Advances
The rational targeting of a transcription factor, interferon regulatory factor 5 (IRF5), inhibits downstream functions.
The transcription factor interferon regulatory factor 5 (IRF5) plays essential roles in pathogen-induced immunity downstream
The transcription factor interferon regulatory factor 5 (IRF5) plays essential roles in pathogen-induced immunity downstream
Autor:
Kris A. Reedquist, John Woods, Julie DeMartino, Jay S. Fine, Satwant K. Narula, Man Wai Tang, Michael F Smith, L. M. Hartkamp, Inge E. van Es, Paul P. Tak
Publikováno v:
Annals of the rheumatic diseases, 74(8), 1603-1611. BMJ Publishing Group
Objectives Bruton9s tyrosine kinase (Btk) is required for B lymphocyte and myeloid cell contributions to pathology in murine models of arthritis. Here, we examined the potential contributions of synovial Btk expression and activation to inflammation
Autor:
Meera Ramanujam, Daigen Xu, Soo Min, John Woods, Jennifer Postelnek, Julia Ayala, Kai-Yeung Lau, Holly Hilton, Julie Hang, Yong Kim, Julie DeMartino, Rosario Garrido, Mario Giron, Stella Stefanova, Satwant K. Narula, Nena Dimaano, Toni Whittard, Natalie D. Keirstead, Alka Patel, Jacob LaStant, Paola Mina-Osorio
Publikováno v:
Arthritis & Rheumatism. 65:2380-2391
Objective Bruton's tyrosine kinase (BTK) plays a critical role in B cell development and function. We recently described a selective BTK inhibitor, RN486, that blocks B cell receptor (BCR) and Fcγ receptor signaling and is efficacious in animal mode
Autor:
Jayne Chin, Julie DeMartino, Shu Jin, Valerie Carvajal, Rupal Majmudar, Christopher Kitson, John Allard, Dori A. Thomas-Karyat, John Woods, Satwant K. Narula
Publikováno v:
International Immunology. 25:497-506
Organ transplant patients are often treated with immunosuppressants, such as the calcineurin phosphatase inhibitor, cyclosporin A, to block T cell-mediated graft rejection. The calcium release-activated calcium (CRAC/ORAI) channels, which act upstrea
Autor:
Julie DeMartino, Ronald J. Hill, Jay S. Fine, Alison O'Mahony, Jennifer Postelnek, Cheng Liao, Dinesh Srinivasan, Michael Bradshaw, Anita Levin, Daigen Xu, Yong Kim, Satwant K. Narula, Achal Pashine, Dong-Qing Hu, John Woods, Jonathan Hsu, Minh Diem Vu, Yan Lou, Jun Zhang, Timothy D. Owens
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 341:90-103
Genetic mutation and pharmacological inhibition of Bruton9s tyrosine kinase (Btk) both have been shown to prevent the development of collagen-induced arthritis (CIA) in mice, providing a rationale for the development of Btk inhibitors for treating rh
Autor:
Stephen R. Indelicato, Nicholas J Murgoloa, Aileen Schilling, Steven H Weiner, Susan Sehring, Richard W. Chapman, Chung-Her Jenha, Xiomara Fernandez, Diljeet Athwal, Spencer J Emtage, Mary Ann Coxa, Sue Stephens, Mark W. Bodmer, Jacqueline M Carter, Dawn Stelts, Chuan-Chu Choua, J. A. Zurcher, William Kreutner, Ted T Kunga, Michael Minnicozzi, Nancy Genatt, Satwant K. Narula, Peter J. Mauser, Robert W. Egan, S. Shane Taremi, Paul J. Zavodny, Petro Mary E
Publikováno v:
Arzneimittelforschung. 49:779-790
This report describes the development and the biology of Sch 55700, a humanized monoclonal antibody to human IL-5 (hIL-5). Sch 55700 was synthesized using CDR (complementarity determining regions) grafting technology by incorporating the antigen reco
Autor:
Charles A. Lunn, James V. Jackson, Jay S. Fine, Waldemar Gonsiorek, James Fossetta, David Kinsley, David Hesk, Joseph A. Kozlowski, Satwant K. Narula, R. William Hipkin, Shu-Cheng Chen, Hong Bian, Daniel Lundell, Gregory Deno, Brian J. Lavey, Loretta A. Bober, Piwinski John J
Publikováno v:
Journal of Biological Chemistry. 281:28143-28151
Studies to characterize the endogenous expression and pharmacology of peripheral human cannabinoid receptor (hCB2) have been hampered by the dearth of authentic anti-hCB2 antibodies and the lack of radioligands with CB2 selectivity. We recently descr
Autor:
Petro Mary E, Charlene Desquitado, Martin A. Schwarz, Satwant K. Narula, Benedict Gomes, Karen Du, Chung-Her Jenh, Charles A. Lunn, Brian Wilburn, Paul J. Zavodny, Daniel Lundell, Maria T. Wiekowski, Mary Ann Cox, Kyle Palmer, Chuan-Chu Chou
Publikováno v:
Biochemical and Biophysical Research Communications. 330:467-473
The human P2Y6 receptor (hP2Y6) is a member of the G protein-coupled pyrimidinergic P2 receptor family that responds specifically to the extracellular nucleotide uridine diphosphate (UDP). Recently, the hP2Y6 receptor has been reported to mediate mon
Autor:
Galya Vassileva, Petro Mary E, Long Cui, Inhou Chu, Satwant K. Narula, Andrei Golovko, Lily Yang, Amin A. Nomeir, Catherine Pugliese-Sivo, Paul J. Zavodny, Li-Kang Zhang, Joseph A. Kozlowski, Xian Liang, Chuan-Chu Chou, Eva-Pia Reich
Publikováno v:
European Journal of Immunology. 35:1027-1036
The KCNN4 potassium-ion channel has been reported to play an important role in regulating antigen-induced T cell effector functions in vitro. This study presents the first evidence that a selective KCNN4 blocker, TRAM-34, confers protection against e
Autor:
E. J. Remarque, Chuan-Chu Chou, B. A. ‘t Hart, Jayaram R. Tagat, Michel P.M. Vierboom, Julie M. Strizki, Catherine Pugliese-Sivo, Steensma Ruo, Paul J. Zavodny, Margreet Jonker, Satwant K. Narula, Stuart W. McCombie, Liesbeth Celebi-Paul
Publikováno v:
Arthritis & Rheumatism. 52:627-636
Objective Collagen-induced arthritis (CIA) in the rhesus monkey is a nonhuman primate model of rheumatoid arthritis (RA). The close phylogenetic relationship between humans and the rhesus monkey makes this model useful for the preclinical safety and