Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Satu, Juhila"'
Autor:
Raymond Pieters, Klaus Gjervig Jensen, Philip G. Hewitt, Jan Snoeys, Bob van de Water, B. Kevin Park, Ursula Klingmüller, André Guillouzo, Ian M. Copple, Dominic P. Williams, Michael J. Liguori, Cerys A. Lovatt, Paul Morgan, Satu Juhila, Eric A.G. Blomme, Magnus Ingelman-Sundberg, Dean J. Naisbitt, Gilles Labbe, Amy E. Chadwick, Christopher E. Goldring, Helga H.J. Gerets, Richard J. Weaver
Publikováno v:
Nature Reviews Drug Discovery
Nature Reviews Drug Discovery, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
Nature Reviews Drug Discovery, Nature Publishing Group, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
NATURE REVIEWS DRUG DISCOVERY
Nature Reviews Drug Discovery, 19, 131-148
Nature Reviews Drug Discovery, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
Nature Reviews Drug Discovery, Nature Publishing Group, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
NATURE REVIEWS DRUG DISCOVERY
Nature Reviews Drug Discovery, 19, 131-148
International audience; Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 77:129005
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candida
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128783
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Autor:
Mikael Persson, Helga H.J. Gerets, Klaus Gjervig Jensen, Natalie Mesens, Jan Snoeys, B. Kevin Park, Tracy Walker, James L. Stevens, Catherine J. Betts, Gilles Labbe, Monday O. Ogese, Richard J. Weaver, Philip G. Hewitt, Michael J. Liguori, Eric A.G. Blomme, Satu Juhila
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 13:767-782
Introduction: The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue
Autor:
Richard J, Weaver, Catherine, Betts, Eric A G, Blomme, Helga H J, Gerets, Klaus, Gjervig Jensen, Philip G, Hewitt, Satu, Juhila, Gilles, Labbe, Michael J, Liguori, Natalie, Mesens, Monday O, Ogese, Mikael, Persson, Jan, Snoeys, James L, Stevens, Tracy, Walker, B Kevin, Park
Publikováno v:
Expert opinion on drug metabolismtoxicology. 13(7)
The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue for drug deve
Autor:
David C. Hay, Satu Juhila, Christopher E. Goldring, Frank Bonner, Alan Norris, Neil A. Hanley, Belen Tornesi, Robert J. Fontana, B. Kevin Park, Chris S. Pridgeon, Chris Denning, Richard J. Weaver, Bob van de Water, Beatriz Silva-Lima, Neil R. Kitteringham, Rowena Sison Young, Magnus Ingelman-Sundberg, Jonathan Crozier, Daniel J. Antoine, Danilo Tagle, James A. Ross, Fang Zhang
Publikováno v:
HEPATOLOGY
Goldring, C E, Antoine, D J, Bonner, F, Crozier, J, Denning, C, Fontana, R, Hanley, N A, Hay, D C, Ingelman-Sundberg, M, Juhila, S, Kitteringham, N R, de Lima, B, Norrish, A, Pridgeon, C S, Ross, J, Sison-Young, R L C, Tagle, D, Tournesi, B, van der Water, B, Weaver, R, Zhang, F & Park, K 2017, ' Stem cell-derived models to improve mechanistic understanding and prediction of human drug induced liver injury ', Hepatology, pp. 710-721 . https://doi.org/10.1002/hep.28886
Goldring, C, Antoine, D J, Bonner, F, Crozier, J, Denning, C, Fontana, R J, Hanley, N A, Hay, D C, Ingelman-Sundberg, M, Juhila, S, Kitteringham, N, Silva-Lima, B, Norris, A, Pridgeon, C, Ross, J A, Young, R S, Tagle, D, Tornesi, B, van de Water, B, Weaver, R J, Zhang, F & Park, B K 2016, ' Stem cell–derived models to improve mechanistic understanding and prediction of human drug-induced liver injury ', Hepatology, vol. 65, no. 2, pp. 710-721 . https://doi.org/10.1002/hep.28886
Hepatology
Hepatology, 65(2), 710-721
Goldring, C E, Antoine, D J, Bonner, F, Crozier, J, Denning, C, Fontana, R, Hanley, N A, Hay, D C, Ingelman-Sundberg, M, Juhila, S, Kitteringham, N R, de Lima, B, Norrish, A, Pridgeon, C S, Ross, J, Sison-Young, R L C, Tagle, D, Tournesi, B, van der Water, B, Weaver, R, Zhang, F & Park, K 2017, ' Stem cell-derived models to improve mechanistic understanding and prediction of human drug induced liver injury ', Hepatology, pp. 710-721 . https://doi.org/10.1002/hep.28886
Goldring, C, Antoine, D J, Bonner, F, Crozier, J, Denning, C, Fontana, R J, Hanley, N A, Hay, D C, Ingelman-Sundberg, M, Juhila, S, Kitteringham, N, Silva-Lima, B, Norris, A, Pridgeon, C, Ross, J A, Young, R S, Tagle, D, Tornesi, B, van de Water, B, Weaver, R J, Zhang, F & Park, B K 2016, ' Stem cell–derived models to improve mechanistic understanding and prediction of human drug-induced liver injury ', Hepatology, vol. 65, no. 2, pp. 710-721 . https://doi.org/10.1002/hep.28886
Hepatology
Hepatology, 65(2), 710-721
Current preclinical drug testing does not predict some forms of adverse drug reactions in humans. Efforts at improving predictability of drug-induced tissue injury in humans include using stem cell technology to generate human cells for screening for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbacc462a980918f9159ad06183577a
https://hdl.handle.net/1887/69184
https://hdl.handle.net/1887/69184
Autor:
Rowena Sison-Young, Alison J. Foster, Satu Juhila, Christopher E. Goldring, Dominic P. Williams, Cerys A. Lovatt, Andreas Czich, Audrey Baze, Céline Parmentier, Lysiane Richert, B. Kevin Park, Martina Dorau, Helga H.J. Gerets
Publikováno v:
TOXICOLOGY LETTERS
Sixteen training compounds selected in the IMI MIP-DILI consortium, 12 drug-induced liver injury (DILI) positive compounds and 4 non-DILI compounds, were assessed in cryopreserved primary human hepatocytes. When a ten-fold safety margin threshold was
Autor:
Philip G. Hewitt, Satu Juhila, B. Kevin Park, Helga H.J. Gerets, Sanja Dragovic, Nico P. E. Vermeulen, Richard J. Weaver, Magnus Ingelman-Sundberg, Jan Snoeys
Publikováno v:
Archives of Toxicology, 90(12), 2979-3003. Springer Verlag
Archives of Toxicology
Dragovic, S, Vermeulen, N P E, Gerets, H H, Hewitt, P G, Ingelman-Sundberg, M, Park, B K, Juhila, S, Snoeys, J & Weaver, R J 2016, ' Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man. ', Archives of Toxicology, vol. 90, no. 12, pp. 2979-3003 . https://doi.org/10.1007/s00204-016-1845-1
ARCHIVES OF TOXICOLOGY
Archives of Toxicology
Dragovic, S, Vermeulen, N P E, Gerets, H H, Hewitt, P G, Ingelman-Sundberg, M, Park, B K, Juhila, S, Snoeys, J & Weaver, R J 2016, ' Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man. ', Archives of Toxicology, vol. 90, no. 12, pp. 2979-3003 . https://doi.org/10.1007/s00204-016-1845-1
ARCHIVES OF TOXICOLOGY
The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The ‘MIP-DILI’ project addresses this situation by the development of innovative preclinical test systems which are both mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ef9bb31c2a1cd2360aa8d263504fdd
https://research.vu.nl/en/publications/c4fc74b6-d177-4e55-9112-e26a38048507
https://research.vu.nl/en/publications/c4fc74b6-d177-4e55-9112-e26a38048507