Výsledky vyhledávání - "Satsuki Iwase"

Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells

Autor: Satsuki Iwase, Yusuke Furukawa, Hisashi Yamada, Shinobu Saito, Takeshi Kawano, Yasuhiko Kano, Junko Horiguchi-Yamada

Publikováno v: Leukemia Research. 28:623-629

Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid differentiation of K562 cells. During this erythroid differentiation, c-Myc and cyclin D1 transcripts are transiently downregulated. Accordingly, we studied the effect of cyclin D1 ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd02ee3e2be451b534cbbda3d002052
https://doi.org/10.1016/j.leukres.2003.10.022

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Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it

Autor: Takeshi Kawano, Satsuki Iwase, Yasuhiko Kano, Yusuke Furukawa, Junko Horiguchi-Yamada, Hisashi Yamada

Publikováno v: Molecular and Cellular Biochemistry. 258:25-33

K562 cells contain a Bcr-Abl chimeric gene and differentiate into various lineages in response to different inducers. We studied the role of the mitogen-activated protein kinase (MAPK) kinase 1 (MEK1)/extracellular signal-regulated kinase (ERK) pathw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaff68a54200a584b546286cff5bcfe5
https://doi.org/10.1023/b:mcbi.0000012830.96393.b9

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No VH Somatic Hypermutation Was Detected in B-Cells of a Patient with Macroglobulinemia Due to Splenic Marginal Zone Lymphoma

Autor: Tetsuaki Sekikawa, Shuji Nakada, Satsuki Iwase, Kiyoshi Ito, Masayuki Kobayashi, Shinobu Takahara, Takeshi Kawano, Hisashi Yamada, Junko Horiguchi-Yamada

Publikováno v: International Journal of Hematology. 76:453-459

B-cell diseases are classified on the basis of the normal differentiation stages. We report here a case of a patient with a long history of leukocytosis, splenomegaly without lymphadenopathy, and hyperviscosity symptoms. Clinically, the patient's dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb03530c77070213cd5f6629c17dcca
https://doi.org/10.1007/bf02982811

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Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiation

Autor: Yusuke Furukawa, Hisashi Yamada, Satsuki Iwase, Michio Matsuda, Jiro Kikuchi, Mitsuru Nakamura

Publikováno v: British Journal of Haematology. 110:663-673

To maintain the fidelity and integrity of blood formation, the cell cycle is under strict regulation during haematopoietic cell differentiation. To elucidate the molecular mechanisms of cell cycle regulation during haematopoiesis, we examined cell cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::482ca29a0cbdf1425f91824fa12d9041
https://doi.org/10.1046/j.1365-2141.2000.02253.x

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Transcriptional repression of the E2F-1 gene by interferon-α is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes

Autor: Mitsuru Nakamura, Satsuki Iwase, Michio Matsuda, Yusuke Furukawa, Jiro Kikuchi, Hisashi Yamada

Publikováno v: Oncogene. 18:2003-2014

E2F is a heterodimeric transcription factor composed of one of five E2F subunits (E2F-1 to E2F-5) and a DP subunit. E2F regulates the expression of several growth-promoting genes, and thus, can be a target of antiproliferative action of interferons (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41aabaf4bc2c89a0a37225eef35a3479
https://doi.org/10.1038/sj.onc.1202500

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A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

Autor: Shyu Tanimura, Yusuke Furukawa, Takasi Fujita, Akihiko Yoshimura, Satsuki Iwase, Masaaki Masuhara, Tsunetaka Ohta, Akira Ohtsuka, Motoaki Ohtsubo, Kentaro Yuge, Hideo Yasukawa, Hiroshi Sakamoto, Hisashi Yamada, Atsuo T. Sasaki

Publikováno v: Blood. 92:1668-1676

It has been shown that interferons (IFNs) exert their signals through receptor-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). However, molecular mechanism of regulation of IFN signaling has not been fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f63c2b4651e9ae884c0c2b1181bed0
https://doi.org/10.1182/blood.v92.5.1668

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Band 3 Tokyo: Thr837-->Ala837 Substitution in Erythrocyte Band 3 Protein Associated with Spherocytic Hemolysis

Autor: Satsuki Iwase, Mayumi Takao, Hiroshi Ideguchi, Tetsuaki Sekikawa, Shinobu Takahara, Hisashi Yamada, Masafumi Iwasaki, Seibu Mochizuki, Junko Horiguchi-Yamada

Publikováno v: Acta Haematologica. 100:200-203

We report a case of spherocytosis associated with erythrocyte band 3 deficiency. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of erythrocyte membrane proteins showed that the patient’s band 3 was reduced to about 80% of the control lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a435a0a0480f363571e919ffd186ee1a
https://doi.org/10.1159/000040904

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[Untitled]

Autor: Makoto Nagai, Shinobu Takahara, Junko Horiguchi-Yamada, Satsuki Iwase, Tetsuaki Sekikawa, Takeshi Kawano, Hisashi Yamada, Sachiko Fukumi, Kiyoshi Itoh

Publikováno v: Molecular and Cellular Biochemistry. 187:211-220

Therapeutic strategies for leukemia are directed to induction of differentiation and apoptosis as well as growth inhibition. One of the key antileukemic agents, 1-β-D-arabinofuranosylcytosine (ara C), is clinically applied according to these therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe745af2a59a7316e13dc71db1c499c1
https://doi.org/10.1023/a:1006874931249

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