iPRESTO: Automated discovery of biosynthetic sub-clusters linked to specific natural product substructures.

Autor: Joris J R Louwen, Satria A Kautsar, Sven van der Burg, Marnix H Medema, Justin J J van der Hooft

Publikováno v: PLoS Computational Biology, Vol 19, Iss 2, p e1010462 (2023)

Microbial specialised metabolism is full of valuable natural products that are applied clinically, agriculturally, and industrially. The genes that encode their biosynthesis are often physically clustered on the genome in biosynthetic gene clusters (

Externí odkaz: https://doaj.org/article/419ecef4d2274796a4183bc7e93ac229

The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes

Autor: Simon Shaw, Kai Blin, Marnix H. Medema, Tilmann Weber, Satria A. Kautsar

Publikováno v: Blin, K, Shaw, S, Kautsar, S A, Medema, M H & Weber, T 2021, ' The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes ', Nucleic Acids Research, vol. 49, no. D1, pp. D639–D643 . https://doi.org/10.1093/nar/gkaa978
Nucleic Acids Research
Nucleic acids research, 49(D1), D639-D643
Nucleic acids research 49 (2021) D1

Microorganisms produce natural products that are frequently used in the development of antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent years, genome mining has evolved into a prominent method to access

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bded04d5b7be7dcbdb3552cf7250aba0
https://doi.org/10.1093/nar/gkaa978

Author Correction: Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes

Autor: Athina Gavriilidou, Satria A. Kautsar, Nestor Zaburannyi, Daniel Krug, Rolf Müller, Marnix H. Medema, Nadine Ziemert

Publikováno v: Nature Microbiology, 7(8), 1324-1324
Nature Microbiology 7 (2022) 8

In the version of this article initially published, for author Satria A. Kaustar, a present address with the Chemistry Department, Scripps Research, was incorrectly included. The affiliation has now been removed from the HTML and PDF versions of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9883dfb481948256ff4c1a2a0819bba
https://research.wur.nl/en/publications/author-correction-compendium-of-specialized-metabolite-biosynthet

Mapping natural product diversity through genomics

Autor: Satria A. Kautsar

Background: Natural products (NP) from plants and microbes are a rich source for bioactive compounds essential for human life. A large part of agriculture, lifestyle and healthcare practice relies on metabolites derived from natural sources. To exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e284bd5e52672a648b47d5c2ec1ba68
https://doi.org/10.18174/543999

Uncharted biosynthetic potential of the ocean microbiome

Autor: Quentin Clayssen, Georg Zeller, Martin Larralde, Patrick Wincker, Chris Bowler, Peer Bork, Satria A. Kautsar, Jörn Piel, Serina L. Robinson, Clarissa C. Forneris, Alessio Milanese, Shinichi Sunagawa, Matthew B. Sullivan, Guillem Salazar, Pablo Sánchez, Silvia G. Acinas, Laura M. Carroll, Hans-Joachim Ruscheweyh, Lucas Paoli, Tom O. Delmont, Dylan R. Cronin, Ahmed A. Zayed, Daniel Gehrig

SummaryMicrobes are phylogenetically and metabolically diverse. Yet capturing this diversity, assigning functions to host organisms and exploring the biosynthetic potential in natural environments remains challenging. We reconstructed >25,000 draft g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8813d5cd53045e69c399ffdcf421e70
https://doi.org/10.1101/2021.03.24.436479