Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Satrajit Sinha"'
Autor:
Ukjin Kim, Rahul Debnath, Javier E. Maiz, Joshua Rico, Satrajit Sinha, Mario Andrés Blanco, Rumela Chakrabarti
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109366- (2024)
Summary: Triple-negative breast cancer (TNBC) contributes greatly to mortality of breast cancer, demanding new targetable options. We have shown that TNBC patients have high ΔNp63 expression in tumors. However, the function of ΔNp63 in established
Externí odkaz:
https://doaj.org/article/e9fd99b79e7240e78aa30f8687498c0c
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0301082 (2024)
Branching morphogenesis is a complex process shared by many organs including the lungs, kidney, prostate, as well as several exocrine organs including the salivary, mammary and lacrimal glands. This critical developmental program ensures the expansio
Externí odkaz:
https://doaj.org/article/dee215d3c3ed4a299f9ff641cd7c7858
Autor:
Michael Battaglia, Alex C. Sunshine, Wei Luo, Richard Jin, Alifa Stith, Matt Lindemann, Lloyd S. Miller, Satrajit Sinha, Elizabeth Wohlfert, Lee Ann Garrett-Sinha
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionEts1 is a lymphoid-enriched transcription factor that regulates B- and Tcell functions in development and disease. Mice that lack Ets1 (Ets1 KO) develop spontaneous autoimmune disease with high levels of autoantibodies. Naïve CD4 + T cel
Externí odkaz:
https://doaj.org/article/b59a18aefa3f4975951efa03b14bb17b
Publikováno v:
Biology, Vol 13, Iss 2, p 130 (2024)
Follistatin (FST) is a potent neutralizer of the transforming growth factor-β superfamily and is associated with normal cellular programs and various hallmarks of cancer, such as proliferation, migration, angiogenesis, and immune evasion. The aberra
Externí odkaz:
https://doaj.org/article/bc6385a9c86a458e89d23d89d0b18cd6
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Traditional analysis of genomic data from bulk sequencing experiments seek to group and compare sample cohorts into biologically meaningful groups. To accomplish this task, large scale databases of patient-derived samples, like that of TCGA, have bee
Externí odkaz:
https://doaj.org/article/54ec01c5aed740febbaf53f57adb5380
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Background ΔNp63 is a master transcriptional regulator playing critical roles in epidermal development and other cellular processes. Recent studies suggest that ΔNp63 functions as a pioneer factor that can target its binding sites within i
Externí odkaz:
https://doaj.org/article/a15d84081f2c437eb5a4e796b77f65ed
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The complex heterogeneity of head and neck squamous cell carcinoma (HNSCC) reflects a diverse underlying etiology. This heterogeneity is also apparent within Human Papillomavirus-positive (HPV+) HNSCC subtypes, which have distinct gene expression pro
Externí odkaz:
https://doaj.org/article/97a42fa3b1d541898f7d3b727d6e563e
Autor:
Erich Horeth, Akinsola Oyelakin, Eun-Ah Christine Song, Monika Che, Jonathan Bard, Sangwon Min, Jeremy Kiripolsky, Jill M. Kramer, Satrajit Sinha, Rose-Anne Romano
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sjögren’s Syndrome (SS) is a chronic autoimmune disease of unknown etiology which primarily affects the salivary and lacrimal glands resulting in the loss of secretory function. Treatment options for SS have been hampered due to the lack of a bett
Externí odkaz:
https://doaj.org/article/dc6e5442713e441cae4198893ed50266
Autor:
Akinsola Oyelakin, Erich Horeth, Eun-Ah Christine Song, Sangwon Min, Monika Che, Brandon Marzullo, Christopher J. Lessard, Astrid Rasmussen, Lida Radfar, R. Hal Scofield, David M. Lewis, Donald U. Stone, Kiely Grundahl, Scott S. De Rossi, Zoya Kurago, A. Darise Farris, Kathy L. Sivils, Satrajit Sinha, Jill M. Kramer, Rose-Anne Romano
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized primarily by immune-mediated destruction of exocrine tissues, such as those of the salivary and lacrimal glands, resulting in the loss of saliva and tear production, r
Externí odkaz:
https://doaj.org/article/3fb65dfaf93a4c61bca5997a1f95724b
Autor:
Sangwon Min, Akinsola Oyelakin, Christian Gluck, Jonathan E. Bard, Eun-Ah Christine Song, Kirsten Smalley, Monika Che, Elsa Flores, Satrajit Sinha, Rose-Anne Romano
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101524- (2020)
Summary: Multipotent ΔNp63-positive cells maintain all epithelial cell lineages of the embryonic and adult salivary gland (SG). However, the molecular mechanisms by which ΔNp63 regulates stem/progenitor (SP) cell populations in the SG remains elusi
Externí odkaz:
https://doaj.org/article/ae01f3cd774b42ad92de450b540eb6ec