Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Satpal Virdee"'
Autor:
Satpal Virdee
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 11, Pp 2347-2350 (2022)
The degeneration of nerve fibres following injury was first described by Augustus Waller over 170 years ago. Initially assumed to be a passive process, it is now evident that axons respond to insult via regulated cellular signaling events resulting i
Externí odkaz:
https://doaj.org/article/e49fc1e683964fb1b27c0092e9683cfd
Autor:
Daniel R. Squair, Satpal Virdee
Publikováno v:
Nature Chemical Biology. 18:802-811
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5096b5ec173b60d1bf0eef605264d3b1
https://doi.org/10.1038/s41589-022-01088-2
https://doi.org/10.1038/s41589-022-01088-2
Autor:
Satpal Virdee
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4db1fb5f5688d56ee7623504077ae6c5
https://doi.org/10.1096/fasebj.2022.36.s1.0i145
https://doi.org/10.1096/fasebj.2022.36.s1.0i145
Autor:
Peter D. Mabbitt, Michael P. Coleman, Satpal Virdee, Marc-André Déry, Mathew Stanley, Adam J. Fletcher, Andrea Loreto, Nicola T. Wood, Kuan-Chuan Pao
Publikováno v:
Nature Chemical Biology. 16:1227-1236
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism, where Ub is relayed from an upstream c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a34b16eb3e4d1236aa0e426512e9373
https://doi.org/10.1038/s41589-020-0598-6
https://doi.org/10.1038/s41589-020-0598-6
Autor:
Francisco Bustos, Sunil Mathur, Carmen Espejo-Serrano, Rachel Toth, C James Hastie, Satpal Virdee, Greg M Findlay
Publikováno v:
Life Science Alliance. 5:e202101248
Ubiquitylation enzymes are involved in all aspects of eukaryotic biology and are frequently disrupted in disease. One example is the E3 ubiquitin ligase RNF12/RLIM, which is mutated in the developmental disorder Tønne-Kalscheuer syndrome (TOKAS). RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c1c79f75533deada6abd4d40918b33
https://doi.org/10.26508/lsa.202101248
https://doi.org/10.26508/lsa.202101248
Autor:
Mathieu Soetens, Satpal Virdee, Nicola T. Wood, Virginia De Cesare, Peter D. Mabbitt, Daniel Carbajo Lopez, Adam J. Fletcher, Odetta Antico
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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instname
The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ubiquitin system. Approximately 100 DUBs are encoded by the human genome, and many have been implicated with patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9214985f9b35dad7e01f1b8694bd9116
https://doi.org/10.1073/pnas.2006947118
https://doi.org/10.1073/pnas.2006947118
Publikováno v:
Journal of Molecular Biology. 434:167524
A general approach for the rapid and selective inhibition of enzymes in cells using a common tool compound would be of great value for research and therapeutic development. We previously reported a chemogenetic strategy that addresses this challenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24761abebda07a84bac1fa2c4b08024
https://doi.org/10.1016/j.jmb.2022.167524
https://doi.org/10.1016/j.jmb.2022.167524
Autor:
Satpal Virdee, Daniel Carbajo Lopez, Odetta Antico, Virginia De Cesare, Peter D. Mabbitt, Nicola T. Wood
The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ubiquitin system. Approximately 100 DUBs are encoded by the human genome and many have been implicated with pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44abd960f9eca00db1c31854fee1fc38
https://doi.org/10.1101/2020.05.11.087965
https://doi.org/10.1101/2020.05.11.087965
Publikováno v:
Cell Chemical Biology
Summary Activity-based protein profiling is an invaluable technique for studying enzyme biology and facilitating the development of therapeutics. Ubiquitin E3 ligases (E3s) are one of the largest enzyme families and regulate a host of (patho)physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfee5457efb0cb23f3ece8874d77435
https://eprints.gla.ac.uk/245468/1/245468.pdf
https://eprints.gla.ac.uk/245468/1/245468.pdf
Autor:
Peter D, Mabbitt, Andrea, Loreto, Marc-André, Déry, Adam J, Fletcher, Mathew, Stanley, Kuan-Chuan, Pao, Nicola T, Wood, Michael P, Coleman, Satpal, Virdee
Publikováno v:
Nature chemical biology. 16(11)
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism, where Ub is relayed from an upstream c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1aaaedfcad6589562f658118747d5855
https://pubmed.ncbi.nlm.nih.gov/33067595
https://pubmed.ncbi.nlm.nih.gov/33067595