Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Satpal S. Jhujh"'
Autor:
Laura J. Grange, John J. Reynolds, Farid Ullah, Bertrand Isidor, Robert F. Shearer, Xenia Latypova, Ryan M. Baxley, Antony W. Oliver, Anil Ganesh, Sophie L. Cooke, Satpal S. Jhujh, Gavin S. McNee, Robert Hollingworth, Martin R. Higgs, Toyoaki Natsume, Tahir Khan, Gabriel Á. Martos-Moreno, Sharon Chupp, Christopher G. Mathew, David Parry, Michael A. Simpson, Nahid Nahavandi, Zafer Yüksel, Mojgan Drasdo, Anja Kron, Petra Vogt, Annemarie Jonasson, Saad Ahmed Seth, Claudia Gonzaga-Jauregui, Karlla W. Brigatti, Alexander P. A. Stegmann, Masato Kanemaki, Dragana Josifova, Yuri Uchiyama, Yukiko Oh, Akira Morimoto, Hitoshi Osaka, Zineb Ammous, Jesús Argente, Naomichi Matsumoto, Constance T.R.M. Stumpel, Alexander M. R. Taylor, Andrew P. Jackson, Anja-Katrin Bielinsky, Niels Mailand, Cedric Le Caignec, Erica E. Davis, Grant S. Stewart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The SMC5/6 complex is critical for genome stability. Here, the authors identify mutations in SLF2 and SMC5 as cause of Atelís Syndrome characterized by microcephaly, short stature, anemia, segmented chromosomes and mosaic variegated hyperploidy.
Externí odkaz:
https://doaj.org/article/bfe3845b80824c5996d10d21e1575e9d
Autor:
Bassam Abu-Libdeh, Satpal S. Jhujh, Srijita Dhar, Joshua A. Sommers, Arindam Datta, Gabriel M.C. Longo, Laura J. Grange, John J. Reynolds, Sophie L. Cooke, Gavin S. McNee, Robert Hollingworth, Beth L. Woodward, Anil N. Ganesh, Stephen J. Smerdon, Claudia M. Nicolae, Karina Durlacher-Betzer, Vered Molho-Pessach, Abdulsalam Abu-Libdeh, Vardiella Meiner, George-Lucian Moldovan, Vassilis Roukos, Tamar Harel, Robert M. Brosh Jr., Grant S. Stewart
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ family of helicases, mutations in RECQL1 have not been
Externí odkaz:
https://doaj.org/article/e82e799461ca42b1a71605c628f57492
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Supplementary Data from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e250212f00f5cee0275162a86dd3d0
https://doi.org/10.1158/0008-5472.22430763
https://doi.org/10.1158/0008-5472.22430763
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Mutations in SF3B1 have been identified across several cancer types. This key spliceosome component promotes the efficient mRNA splicing of thousands of genes including those with crucial roles in the cellular response to DNA damage. Here, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::364cc5b93440e42b205c4d417aa934cb
https://doi.org/10.1158/0008-5472.c.6513714.v1
https://doi.org/10.1158/0008-5472.c.6513714.v1
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Supplementary Table from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b72cb731bca85602ae22e3e680e94
https://doi.org/10.1158/0008-5472.22430757
https://doi.org/10.1158/0008-5472.22430757
Autor:
Katrina M. Lappin, Eliana M. Barros, Satpal S. Jhujh, Gareth W. Irwin, Hayley McMillan, Fabio G. Liberante, Cheryl Latimer, Melissa J. La Bonte, Ken I. Mills, D. Paul Harkin, Grant S. Stewart, Kienan I. Savage
Publikováno v:
Lappin, K M, Barros, E M, Jhujh, S S, Irwin, G W, McMillan, H, Liberante, F G, Latimer, C, LaBonte, M J, Mills, K I, Harkin, D P, Stewart, G S & Savage, K I 2022, ' Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors ', Cancer Research, vol. 82, no. 5, pp. 819-830 . https://doi.org/10.1158/0008-5472.CAN-21-1843
Cancer Res
Cancer Res
Mutations in SF3B1 have been identified across several cancer types. This key spliceosome component promotes the efficient mRNA splicing of thousands of genes including those with crucial roles in the cellular response to DNA damage. Here, we demonst
Autor:
Arindam Datta, Joshua A. Sommers, Satpal S. Jhujh, Tamar Harel, Grant S. Stewart, Robert M. Brosh
Publikováno v:
Ageing Research Reviews. 86:101887
Autor:
Bassam Abu-Libdeh, Satpal S. Jhujh, Srijita Dhar, Joshua A. Sommers, Arindam Datta, Gabriel M.C. Longo, Laura J. Grange, John J. Reynolds, Sophie L. Cooke, Gavin S. McNee, Robert Hollingworth, Beth L. Woodward, Anil N. Ganesh, Stephen J. Smerdon, Claudia M. Nicolae, Karina Durlacher-Betzer, Vered Molho-Pessach, Abdulsalam Abu-Libdeh, Vardiella Meiner, George-Lucian Moldovan, Vassilis Roukos, Tamar Harel, Robert M. Brosh, Grant S. Stewart
Publikováno v:
The Journal of clinical investigation. 132(5)
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ family of helicases, mutations in RECQL1 have not been
Autor:
Abualfaraj T; Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK., Hagkarim NC; Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK., Hollingworth R; Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK., Grange L; Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK., Jhujh S; Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK., Stewart GS; Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK., Grand RJ; Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK.
Publikováno v:
Viruses [Viruses] 2021 Dec 06; Vol. 13 (12). Date of Electronic Publication: 2021 Dec 06.
Autor:
Salguero I; Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK., Belotserkovskaya R; Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK., Coates J; Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK., Sczaniecka-Clift M; Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK., Demir M; Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK., Jhujh S; Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Wilson MD; Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK., Jackson SP; Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK. s.jackson@gurdon.cam.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2019 Nov 15; Vol. 10 (1), pp. 5191. Date of Electronic Publication: 2019 Nov 15.