Antioxidants rescue photoreceptors in rd1 mice: Relationship with thiol metabolism

Autor: Satpal Ahuja, María Miranda, Per Ekström, Emma Arnal, Raquel Alvarez-Nölting, Theo van Veen, Rosa López-Pedrajas, Francisco J. Romero, Francisco Bosch-Morell

Publikováno v: Free Radical Biology and Medicine. 48:216-222

We have previously shown that the use of a combination of antioxidants delayed the degeneration process in rd1 mouse retina. In an effort to understand the mechanism of action of these substances (zeaxanthin, lutein, alpha-lipoic acid, glutathione, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9791d4caaf646ded8a7ec746e0cb28
https://doi.org/10.1016/j.freeradbiomed.2009.10.042

Decreased glutathione transferase levels in rd1/rd1 mouse retina: Replenishment protects photoreceptors in retinal explants

Autor: Satpal Ahuja, P Ahuja, Per Ekström, A.R. Caffe, T. van Veen

Publikováno v: Neuroscience. 131:935-943

Currently much attention is focused on glutathione S transferase (GST)-induced suppression of apoptosis. The objective of our studies was therefore to see if GST isoenzymes rescue photoreceptors in retinal explants from rd1/rd1 mice, in which photore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b9ca3944bdd19c8c17112c43d84ba4
https://doi.org/10.1016/j.neuroscience.2004.11.012

Proteomic analysis of human vitreous associated with idiopathic epiretinal membrane

Autor: Jesper Grau Eriksen, Morten la Cour, Satpal Ahuja, Jan Ulrik Prause, Nakul Mandal, Henrik Vorum, Bent Honoré, Mads Kofod, Jørgen Villumsen, Steffen Heegaard

Publikováno v: Mandal, N, Kofod, M, Vorum, H, Villumsen, J, Eriksen, J, Heegaard, S, Prause, J U, Ahuja, S, Honoré, B & Dornonville de la Cour, M 2013, ' Proteomic analysis of human vitreous associated with idiopathic epiretinal membrane. ', Acta Ophthalmologica (Online), pp. 333-334 .
Aarhus University
Mandal, N, Kofod, M, Vorum, H, Villumsen, J, Eriksen, J, Heegaard, S, Prause, J U, Ahuja, S, Honoré, B & la Cour, M 2013, ' Proteomic analysis of human vitreous associated with idiopathic epiretinal membrane ', Acta Ophthamologica, vol. 91, no. 4, pp. e333-e334 . https://doi.org/10.1111/aos.12075

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca928fd35a13a671831dd65bfb25de0
https://pure.au.dk/portal/da/publications/proteomic-analysis-of-human-vitreous-associated-with-idiopathic-epiretinal-membrane(8175c46d-c9dd-4744-99d6-26078ca398a7).html

Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration

Autor: Satpal Ahuja, Per Ekström, T. van Veen, M.M. Sanz, Juan Eduardo Romero, Leif E. Johnson

Publikováno v: Neuroscience. 145(3)

The purpose of this study was to investigate the presence of oxidative DNA damage in the photoreceptors of the rd1 mouse, an animal model for retinitis pigmentosa, and to determine if antioxidants could delay the progress of photoreceptor cell death.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcb205a3d872a3ce2127a62eb3e953a
https://pubmed.ncbi.nlm.nih.gov/17293057

rd1 mouse retina shows imbalance in cellular distribution and levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and sulfated glycosaminoglycans

Autor: Satpal, Ahuja, Poonam, Ahuja, A Romeo, Caffé, Per, Ekstrom, Magnus, Abrahamson, Theo, van Veen

Publikováno v: Ophthalmic research. 38(3)

The rd1 mouse retina displays fast degeneration of photoreceptors resulting in a depletion of almost all rod photoreceptors by postnatal day 21 (PN21). To evaluate the role of proteinases in the pathophysiology of this animal model of retinitis pigme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75c27774e3f5f0a723351a06a433c455
https://pubmed.ncbi.nlm.nih.gov/16374054