Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Satoshi Sogabe"'
Autor:
Sachio Shibata, Satoshi Sogabe, Masanori Miwa, Takuya Fujimoto, Nobuyuki Takakura, Akihiko Naotsuka, Shuji Kitamura, Tomohiro Kawamoto, Tomoyoshi Soga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+; it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell pr
Externí odkaz:
https://doaj.org/article/f9c30a90aae44dd1abe0ffa04ef29aac
Autor:
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Agonistic profiles of AMPA receptor (AMPA-R) potentiators may be associated with seizure risk and bell-shaped dose-response effects. Here, we report the pharmacological characteristics of a novel AMPA-R potentiator, TAK-653, which exhibits m
Externí odkaz:
https://doaj.org/article/0d63b239f564462aba95ccd87d503257
Autor:
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/8ad097acaf434529807db669202d1f2f
Autor:
Shuhei Ikeda, Hideyuki Sugiyama, Hidekazu Tokuhara, Masataka Murakami, Minoru Nakamura, Yuya Oguro, Jumpei Aida, Nao Morishita, Satoshi Sogabe, Douglas R. Dougan, Sean C. Gay, Ling Qin, Naoto Arimura, Yasuko Takahashi, Masako Sasaki, Yusuke Kamada, Kazunobu Aoyama, Kouya Kimoto, Makoto Kamata
Publikováno v:
Journal of Medicinal Chemistry. 64:11014-11044
The therapeutic potential of monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases has attracted attention worldwide. However, the availability of reversible-type inhibitor is still limited to clarify the pharmacologica
Autor:
Noriko Suzuki, Yasukazu Tajima, Akiyoshi Kunugi, Motohisa Suzuki, Atsushi Suzuki, Satoshi Sogabe, Yasuyuki Awasaki, Tomohiro Kaku, Masashi Toyofuku, Haruhiko Kuno, Haruhide Kimura, Yohei Kosugi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Autor:
Tomoyoshi Soga, Satoshi Sogabe, Takuya Fujimoto, Tomohiro Kawamoto, Nobuyuki Takakura, Shuji Kitamura, Masanori Miwa, Sachio Shibata, Akihiko Naotsuka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+; it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4268160f6405b1c33fef5e186d4693a5
https://doi.org/10.21203/rs.3.rs-95794/v1
https://doi.org/10.21203/rs.3.rs-95794/v1
Autor:
Shin-ichi Matsumoto, Yumi Zama, Hideyuki Oki, Kotaro Sakamoto, Yoshihiro Ishibashi, Satoshi Sogabe, Junichi Sakamoto, Akiyoshi Tani, Yusuke Kamada, Ryutaro Adachi
Publikováno v:
Peptides. 94:56-63
Cytidine triphosphate synthase 1 (CTPS1) is an enzyme expressed in activated lymphocytes that catalyzes the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP) with ATP-dependent amination, using either L-glutamine or ammonia as t
Autor:
Satoshi Sogabe, Ayumu Niida, Tomoya Sameshima, Kazuko Yonemori, Junichi Sakamoto, Masanori Miwa, Shigekazu Sasaki, Kotaro Sakamoto, Yusuke Kamada, Masahiro Kamaura
Publikováno v:
ACS Medicinal Chemistry Letters. 8:732-736
The Ras proteins play roles in cell differentiation, proliferation, and survival. Aberrant signaling through Ras-mediated pathways in tumor cells occurs as a result of several types of mutational damage, which most frequently affects the amino acids
Autor:
Satoshi Sogabe, Shoichi Nakao, Tomohiro Kawamoto, Misa Iwatani, Samuel Aparicio, Yasuhiro Imaeda, Toshio Tanaka, Masahiro Ito, Atsushi Nakanishi, Yusuke Kamada
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2200-2209
Eukaryotic initiation factor 4A3 (eIF4A3), an ATP-dependent RNA helicase, is a core component of exon junction complex (EJC). EJC has a variety of roles in RNA metabolism such as translation, surveillance, and localization of spliced RNA. It is worth
Autor:
Robert E. Davis, Lawrence P. Wennogle, Peng Li, Joseph P. Hendrick, Satoshi Sogabe, Wei Yao, Gyorgy Snell, Hailin Zheng, J. David Beard, Zhao Jun, Gretchen L. Snyder, Lei Zhang, Weston Lane, Koh Ida, Charles J. Heyser, Hongwen Zhu, Kimberly E. Vanover
Publikováno v:
Journal of Medicinal Chemistry. 59:1149-1164
A diverse set of 3-aminopyrazolo[3,4-d]pyrimidinones was designed and synthesized. The structure-activity relationships of these polycyclic compounds as phosphodiesterase 1 (PDE1) inhibitors were studied along with their physicochemical and pharmacok