Zobrazeno 1 - 10 of 83 pro vyhledávání: '"Satoshi Okano"'
1
Akademický článek
Heme deficiency in skeletal muscle exacerbates sarcopenia and impairs autophagy by reducing AMPK signaling
Autor: Takeru Akabane, Hiromori Sagae, Koen van Wijk, Shinichi Saitoh, Tomohiro Kimura, Satoshi Okano, Ken Kodama, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Michiaki Takagi, Osamu Nakajima
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Heme serves as a prosthetic group in hemoproteins, including subunits of the mammalian mitochondrial electron transfer chain. The first enzyme in vertebrate heme biosynthesis, 5-aminolevulinic acid synthase 1 (ALAS1), is ubiquitously express
Externí odkaz: https://doaj.org/article/53a9e544ddb14ada9afd52a964b9cb31
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2
Akademický článek
Influence of filtering on the effective concentration and sterility of a 2% cyclosporine ophthalmic solution: a quality improvement perspective
Autor: Masakazu Ozaki, Toshihiko Kobayashi, Aki Fujinaga, Mitsuaki Nishioka, Kyoko Shikichi, Satoshi Okano, Yasuhito Sakai, Sayumi Fujii, Nobuaki Matsui, Miwako Takasago, Naoto Okada, Takahiro Yamasaki, Takashi Kitahara
Publikováno v: Journal of Pharmaceutical Health Care and Sciences, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Background Pharmaceutical companies do not sell formulations for all diseases; thus, healthcare workers have to treat some diseases by concocting in-hospital preparations. An example is the high-concentration 2% cyclosporine A (CyA) ophthalm
Externí odkaz: https://doaj.org/article/aa4113ea04394a03abef6823a5f962e2
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3
Akademický článek
The effects of oxygen addition on microstructure and mechanical properties of Ti-Mo alloys for biomedical application
Autor: Sengo Kobayashi, Satoshi Okano
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
The effective use of oxygen as an alloying element in Ti alloys is attractive due to the reduction of production cost and the increase in strength and hardness of the alloy. Although the oxygen addition in a Ti alloy increases strength and hardness,
Externí odkaz: https://doaj.org/article/03f708b07014493caebd0a04a813b71d
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4
Akademický článek
A classical mechanical model of two interacting massless particles in de Sitter space and its quantization
Autor: Naohiro Kanda, Satoshi Okano
Publikováno v: Physics Letters B, Vol 820, Iss , Pp 136520- (2021)
A conformally invariant model of two interacting massless particles in Minkowski space was proposed by Casalbuoni and Gomis [1]. We generalize this model to the case of de Sitter space from the perspective of geodesic distance, in such a way that the
Externí odkaz: https://doaj.org/article/951247e75fb44d3d8ba32413090117f7
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5
Akademický článek
Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice
Autor: Satoshi Okano, Akira Yasui, Shin-ichiro Kanno, Kennichi Satoh, Masahiko Igarashi, Osamu Nakajima
Publikováno v: Journal of Diabetes Research, Vol 2019 (2019)
Our earlier studies demonstrated that cysteine414- (zinc-binding site of mCRY1-) alanine mutant mCRY1 transgenic mice (Tg mice) exhibit diabetes characterized by the reduction of β-cell proliferation and by β-cell dysfunction, presumably caused by
Externí odkaz: https://doaj.org/article/ba38f06fd21e400a953dfcc0bb1362f1
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6
Akademický článek
5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice.
Autor: Shinichi Saitoh, Satoshi Okano, Hidekazu Nohara, Hiroshi Nakano, Nobuyuki Shirasawa, Akira Naito, Masayuki Yamamoto, Vincent P Kelly, Kiwamu Takahashi, Tohru Tanaka, Motowo Nakajima, Osamu Nakajima
Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0189593 (2018)
In vertebrates, the initial step in heme biosynthesis is the production of 5-aminolevulinic acid (ALA) by ALA synthase (ALAS). ALA formation is believed to be the rate-limiting step for cellular heme production. Recently, several cohort studies have
Externí odkaz: https://doaj.org/article/efc895c4df474e859b68c6e39f1d1f91
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7
Akademický článek
Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic β-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1
Autor: Satoshi Okano
Publikováno v: Journal of Diabetes Research, Vol 2016 (2016)
Cryptochrome proteins (CRYs), which can bind noncovalently to cofactor (chromophore) flavin adenine dinucleotide (FAD), occur widely among organisms. CRYs play indispensable roles in the generation of circadian rhythm in mammals. Transgenic mice (Tg
Externí odkaz: https://doaj.org/article/82192601ba2147baa712eb50843e712e
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10
1453-P: Possible Delta- to Beta-Cell Transdifferentiation in Aged Diabetic Mutant CRY1 Transgenic Mice
Autor: SATOSHI OKANO, AKIRA YASUI, KENNICHI SATOH, SHIN-ICHIRO KANNO, MASAHIKO IGARASHI, OSAMU NAKAJIMA
Publikováno v: Diabetes. 71
Cysteine414 (zinc-binding site of mCRY1) -alanine mutant mCRY1 transgenic mice (TG) show diabetes characterized by the reduction of β-cell proliferation due to the characters of senescence-associated secretory phenotype (SASP) in β-cells as we have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d40fdfd6be3d8f193cbaa7f10849bee2
https://doi.org/10.2337/db22-1453-p
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