Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Satoshi Niizuma"'
Publikováno v:
Journal of Medicinal Chemistry. 45:748-751
An improved method for the synthesis of (6'R)-6'-C-methylneplanocin A (RMNPA, 2), a potent S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitor, was developed via a chelation-controlled stereoselective addition of MeTiCl(3) to the neplanocin A 6'-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ca5376db1c14759fb130659c85d175
https://doi.org/10.1021/jm010374i
https://doi.org/10.1021/jm010374i
Publikováno v:
The Journal of Organic Chemistry. 63:4489-4493
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4ef69493946f793cdd1b9d068af403f
https://doi.org/10.1021/jo971374m
https://doi.org/10.1021/jo971374m
Publikováno v:
Tetrahedron. 53:13621-13632
Synthesis of neplanocin A, a potent antiviral carbocyclic nucleoside, from adenosine was achieved. An acyclic adeninenucleoside 21, prepared from adenosine, was converted to 4′-keto acyclic derivative 27. When 27 was treated with lithiotrimethylsil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb97cb2e0f30cb9c9657d13c9ec14300
https://doi.org/10.1016/s0040-4020(97)00894-6
https://doi.org/10.1016/s0040-4020(97)00894-6
Autor:
Eitaro Nanba, Mika Endo, Hiromi Tanimura, Jun Ohwada, Shunsuke Nagao, Hisafumi Yamada-Okabe, Hitomi Suda, Satoshi Niizuma, Kenji Taniguchi, Masao Tsukazaki, Nobuo Shimma, Kotaro Ogawa, Masako Ura, Yoko Miyazaki, Takeshi Murata, Sawako Ozawa, Masanori Miwa
Publikováno v:
Cancer chemotherapy and pharmacology. 65(2)
Identification of a novel topoisomerase I inhibitor which shows superior efficacy and less individual variation than irinotecan hydrochloride (CPT-11). A novel camptothecin analog that is effective against breast cancer resistance protein (BCRP)-posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfd5985bdfcb5673590810d3d13d9fe
https://pubmed.ncbi.nlm.nih.gov/19495753
https://pubmed.ncbi.nlm.nih.gov/19495753
Autor:
Mika Endo, Kazuko Kobayashi, Chikako Murasaki, Kenji Morikami, Kotaro Ogawa, Nobuo Shimma, Eitaro Nanba, Yoko Miyazaki, Isao Imperial Higashihak Umeda, Kiyoshi Yoshinari, Hiroshi Fukuda, Masako Ura, Satoshi Niizuma, Hitomi Suda, Takeshi Murata, Hisafumi Okabe, Tsuyoshi Takasuka, Jun Ohwada, Sawako Ozawa, Akira Kawashima, Hiromi Tanimura, Kounosuke Nakano, Masami Kohchi, Masao Tsukazaki
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(7)
Novel hexacyclic camptothecin analogs containing cyclic amidine, urea, or thiourea moiety were designed and synthesized based on the proposed 3D-structure of the topoisomerase I (Topo I)/DNA/camptothecin ternary complex. The analogs were prepared fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8f965c265a318f1024ea6268f17ad7
https://pubmed.ncbi.nlm.nih.gov/19254843
https://pubmed.ncbi.nlm.nih.gov/19254843
Autor:
Kiyoaki Sakata, Kenichi Kawasaki, Michiko Hayase, Hirosato Ebiike, Hidetoshi Shindoh, Tsunehisa Aoyama, Satoshi Sogabe, Kenji Morikami, Nobuo Shimma, Toshihiko Fujii, Yasuhiko Shiratori, Miyako Masubuchi, Tatsuo Ohtsuka, Satoshi Niizuma, Yuko Aoki
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(1)
A new series of acid-stable antifungal agents having strong inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt) has been developed starting from acid-unstable benzofuranylmethyl aryl ether 2. The inhibitor design is based on X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94c9fd497d860f375d6ad64c2fd84c7
https://pubmed.ncbi.nlm.nih.gov/12467623
https://pubmed.ncbi.nlm.nih.gov/12467623
Autor:
Takehiro Okada, Yoshito Nakanishi, Takuo Tsukuda, Satoshi Niizuma, Yukinori Minoshima, Yasuko Satoh, Toshihiko Fujii, Toshiyuki Kawashima, Kiyoaki Sakata, Nobuya Ishii, Mikio Arisawa, Noriyuki Inomata, Osamu Kondoh, Kohji Nagano, Toshio Kitamura, Kohei Koyama, Hidemi Saito, Toshiyuki Tsukaguchi, Shimma Nobuo, Kazuo Hattori, Yuko Aoki
Publikováno v:
Cancer Research. 71:2524-2524
Tumor microenvironment is a major factor influencing treatment resistance to conventional anticancer therapies. Indeed, under “quasi in vivo” conditions, with low oxygen (1%), low pH (6.5) and low glucose concentration (0.01%) to mimic the enviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cace8350e52040190c29ec60940d6ef
https://doi.org/10.1158/1538-7445.am2011-2524
https://doi.org/10.1158/1538-7445.am2011-2524
Publikováno v:
Journal of the American Chemical Society. 117:9101-9102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edce8f2b26bd334a4772df8f8e3d4a99
https://doi.org/10.1021/ja00140a041
https://doi.org/10.1021/ja00140a041