Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Satoshi Nagata"'
Autor:
Ezgi Ozdemir Takase, Ryo Yamasaki, Satoshi Nagata, Mitsuru Watanabe, Katsuhisa Masaki, Hiroo Yamaguchi, Jun-ichi Kira, Hideyuki Takeuchi, Noriko Isobe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract In chronic stages of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalitis (EAE), connexin (Cx)43 gap junction channel proteins are overexpressed because of astrogliosis. To elucidate the role of increased Cx43,
Externí odkaz:
https://doaj.org/article/677e0f459eba49d6aa9029b65a57d82b
Autor:
Hiroki Akiba, Junso Fujita, Tomoko Ise, Kentaro Nishiyama, Tomoko Miyata, Takayuki Kato, Keiichi Namba, Hiroaki Ohno, Haruhiko Kamada, Satoshi Nagata, Kouhei Tsumoto
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Conventional bivalent antibodies against cell surface receptors often initiate unwanted signal transduction by crosslinking two antigen molecules. Biparatopic antibodies (BpAbs) bind to two different epitopes on the same antigen, thus alteri
Externí odkaz:
https://doaj.org/article/696a82eaf9774eec813203793b69403f
Autor:
Satoshi Nagata, Ryo Yamasaki, Ezgi Ozdemir Takase, Kotaro Iida, Mitsuru Watanabe, Katsuhisa Masaki, Marion Heleen Cathérine Wijering, Hiroo Yamaguchi, Jun-ichi Kira, Noriko Isobe
Publikováno v:
Biology, Vol 12, Iss 9, p 1217 (2023)
We previously reported a novel secondary progressive multiple sclerosis (SPMS) model, progressive experimental autoimmune encephalomyelitis (pEAE), in oligodendroglia-specific Cx47-inducible conditional knockout (Cx47 icKO) mice. Based on our prior s
Externí odkaz:
https://doaj.org/article/90bddc8b7a7146269bca5792f1f689bb
Autor:
Tomokazu Yamaguchi, Midori Hoshizaki, Takafumi Minato, Satoru Nirasawa, Masamitsu N. Asaka, Mayumi Niiyama, Masaki Imai, Akihiko Uda, Jasper Fuk-Woo Chan, Saori Takahashi, Jianbo An, Akari Saku, Ryota Nukiwa, Daichi Utsumi, Maki Kiso, Atsuhiro Yasuhara, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Yuji Fujino, Satoru Motoyama, Satoshi Nagata, Josef M. Penninger, Haruhiko Kamada, Kwok-Yung Yuen, Wataru Kamitani, Ken Maeda, Yoshihiro Kawaoka, Yasuhiro Yasutomi, Yumiko Imai, Keiji Kuba
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-
Externí odkaz:
https://doaj.org/article/37a0f877c7f0425f889b230ea8fdf522
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of heavy and light chains is required, the design of BsAbs produced through recombin
Externí odkaz:
https://doaj.org/article/8887dd3574c14623af5fb59364d6b6a2
Autor:
Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Götz, Jun-ichi Kira
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Abstract Background Brain astroglia are activated preceding the onset of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We characterized the effects of brain astroglia on spinal cord inflammation, focusin
Externí odkaz:
https://doaj.org/article/37938b5b62a04f64beb4ea1d43370c05
Autor:
Masamitsu N. Asaka, Daichi Utsumi, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, Yoshihiro Kawaoka, Keiji Kuba, Yasuhiro Yasutomi
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
COVID-19, caused by SARS-CoV-2, has spread worldwide with dire consequences. To urgently investigate the pathogenicity of COVID-19 and develop vaccines and therapeutics, animal models that are highly susceptible to SARS-CoV-2 infection are needed. In
Externí odkaz:
https://doaj.org/article/afea422794d241ba86355d7f4149ba23
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Metastatic breast cancer (BCa) is most often diagnosed months after completion of treatment of the primary tumor when a patient reports physical symptoms. Besides a physical examination, no other alternative recurrence screening m
Externí odkaz:
https://doaj.org/article/27d5b46e859c4c29bc196145697132b7
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Malaria is a deadly infectious disease associated with fundamental changes in the composition of the memory B cell (MBC) compartment, most notably a large expansion of T-bet+ MBCs, termed atypical MBCs. However, we know little about the precursors of
Externí odkaz:
https://doaj.org/article/5c5cfc39160345f482030c6652c46795
Autor:
Elisabete Hiromi Hashimoto, Márcia Kamogae, Tatiana Perez Vanzella, Ilce Mara Syllus Cólus, Ana Paula Frederico Rodrigues Lourenço Bracarense, Maria do Carmo Bittencourt-Oliveira, Eiko Itano, Emília Kiyomi Kuroda, Hajime Kato, Satoshi Nagata, Yoshio Ueno, Ken-Ichi Harada, Elisa Yoko Hirooka
Publikováno v:
Brazilian Archives of Biology and Technology, Vol 55, Iss 1, Pp 151-159 (2012)
This work investigated the effects of co-occurring aflatoxin B1 (AFB1) and microcystin (MC) in aquaculture, using immunohistochemistry and genotoxicity methods. Tilapia (Oreochromis niloticus) were exposed to AFB1 by intraperitoneal and MC (cell extr
Externí odkaz:
https://doaj.org/article/e3f6e3f7be7b4287b44b695c31fa09cd