Výsledky vyhledávání - "Satoshi Mashiko"

Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice

Autor: Akane Ishihara, Fukami Takehiro, Toshiyuki Takahashi, Takashi Murai, Satoshi Mashiko, Junko Ito, Ryuichi Moriya, Zenjun Oda, Yuko Mitobe, Akio Kanatani, Hisashi Iwaasa

Publikováno v: Peptides. 30:1318-1322

Neuropeptide Y (NPY) and its family of peptides are thought to have a major role in the physiological control of energy homeostasis. Among five NPY receptors described, stimulation of the Y2 receptor (Y2R) or inhibition of the Y5 receptor (Y5R) has r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e8fa1144a153991cde95f47e3922b3
https://doi.org/10.1016/j.peptides.2009.04.006

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Chronic Intracerebroventricular Infusion of Nociceptin/Orphanin FQ Produces Body Weight Gain by Affecting Both Feeding and Energy Metabolism in Mice

Autor: Hisashi Ohta, Akio Kanatani, Hiroko Matsushita, Akane Ishihara, Hisashi Iwaasa, Takeshi Tanaka, Tetsuya Kanno, Satoshi Mashiko

Publikováno v: Endocrinology. 150:2668-2673

Nociceptin/orphanin FQ (N/OFQ), an endogenous ligand for opioid receptor-like 1 (ORL1), is involved in various central functions, such as pain, psychological stress, locomotor activity, learning and memory, and feeding regulation. Of these functions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c99b928263caaf6c3a0639d292a43b4
https://doi.org/10.1210/en.2008-1515

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Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine

Autor: Akio Kanatani, Lex H.T. Van der Ploeg, Akira Gomori, Toshiyuki Takahashi, Junko Ito, Akane Ishihara, Ryuichi Moriya, Hiroko Matsushita, Hidefumi Kitazawa, Satoshi Mashiko, Hisashi Iwaasa, Yuko Mitobe, Douglas J. MacNeil, Takehiro Fukami

Publikováno v: Obesity. 16:1510-1515

Objective: To further address the function of the Y5 receptor in energy homeostasis, we investigated the effects of a novel spironolactone Y5 antagonist in diet-induced obese (DIO) mice. Methods and Procedures: Male C57BL/6 or Npy5r−/− mice were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88837af7b9c8206207e0da799c89f340
https://doi.org/10.1038/oby.2008.223

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A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice

Publikováno v: Proceedings of the National Academy of Sciences. 103:7154-7158

Neuropeptide Y (NPY) is thought to have a major role in the physiological control of energy homeostasis. Among five NPY receptors described, the NPY Y5 receptor (Y5R) is a prime candidate to mediate some of the effects of NPY on energy homeostasis, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c396bd3e0ef862e30735347a3d9b593
https://doi.org/10.1073/pnas.0510320103

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Chronic intracerebroventricular infusion of MCH causes obesity in mice

Autor: Takeshi Tanaka, Hiroko Matsushita, Akane Ishihara, Satoshi Mashiko, Masahiko Ito, Akio Kanatani, Minoru Moriya, Akira Gomori, Shigeru Tokita, Mariko Yumoto, Hisashi Iwaasa, Makoto Ito

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 284:E583-E588

Melanin-concentrating hormone (MCH) is a cyclic amino acid neuropeptide localized in the lateral hypothalamus. Although MCH is thought to be an important regulator of feeding behavior, the involvement of this peptide in body weight control has been u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2bd76b65b62e39af78b6ac18524d40b
https://doi.org/10.1152/ajpendo.00350.2002

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Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist

Autor: Yasuyuki Ishii, Tetsuya Kanno, Maki Kanesaka, Satoshi Mashiko, Masaki Ihara, Akane Ishihara, Mikiko Hata, Masahiko Kobayashi, Yushin Tominaga, Megumu Okada, Takehiro Fukami, Takashi Murai, Takeshi Tanaka, Keiko Watanabe, Akio Kanatani, Akira Gomori, Masayasu Hidaka, Takahiro Fukuroda, Nagaaki Sato

Publikováno v: British Journal of Pharmacology. 136:341-346

An experiment was conducted to examine whether a potent, orally active and highly selective neuropeptide Y Y1 receptor antagonist attenuates hyperphagia and obesity in genetically obese Zucker fatty rats. Oral administration of the Y1 antagonist (30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a87d1e9e3c6876d145569ef7f8f48d8
https://doi.org/10.1038/sj.bjp.0704696

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A Typical Y1 Receptor Regulates Feeding Behaviors: Effects of a Potent and Selective Y1 Antagonist, J-115814

Autor: Takahiro Fukuroda, Tomoyuki Ohe, Naomi Murai, Yuji Haga, Akane Ishihara, Yasuyuki Ishii, Tetsuya Kanno, Satoshi Mashiko, Osamu Okamoto, Akio Kanatani, Masaki Ihara, Mikiko Hata, Takehiro Fukami

Publikováno v: Molecular Pharmacology. 59:501-505

Neuropeptide Y (NPY) is a potent feeding stimulant. The orexigenic effect of NPY might be caused in part by the action of Y1 receptors. However, the existence of multiple NPY receptors including a possible novel feeding receptor has made it difficult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a827dcdcaeaa779302beb4a8e215ca
https://doi.org/10.1124/mol.59.3.501

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Role of the Y1 Receptor in the Regulation of Neuropeptide Y-Mediated Feeding: Comparison of Wild-Type, Y1 Receptor-Deficient, and Y5 Receptor-Deficient Mice

Autor: Van der Ploeg Lh, Junko Ito, Masaki Ihara, Satoshi Mashiko, Nishimura S, Takehiro Fukami, Sugimoto N, Naomi Murai, Akio Kanatani, Nancy R. Morin, Saga Y, Douglas J. MacNeil, Takahiro Fukuroda

Publikováno v: Endocrinology. 141:1011-1016

Neuropeptide Y (NPY) increases food intake through the action of hypothalamic NPY receptors. At least six subtypes of NPY, peptide YY (PYY), and pancreatic polypeptide (PP) receptors have been identified in mice. Although the involvement of Y1 and Y5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312e33064256c2be47c877cb758ccd59
https://doi.org/10.1210/endo.141.3.7387

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ENHANCEMENT OF ENDOTHELIUM-DEPENDENT RELAXATION IN THE AORTA FROM STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS AT DEVELOPMENTAL STAGES OF HYPERTENSION

Autor: Megumi Hamano, Takako Tomita, Satoshi Mashiko, Isao Tomita, Takeshi Onda

Publikováno v: Clinical and Experimental Pharmacology and Physiology. 21:857-863

1. Endothelium-dependent relaxation (EDR) in aortic rings from young (8 weeks) and adult (16 weeks and 20 weeks) stroke-prone spontaneously hypertensive rats (SHRSP) was investigated in comparison with age-matched Wistar-Kyoto rats (WKY). 2. At 8 wee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64647133dd4c95f090a9b36fc09c8c8a
https://doi.org/10.1111/j.1440-1681.1994.tb02456.x

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Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice

Autor: Junko Ito, Satoshi Mashiko, Toru Seo, Ryuichi Moriya, Takashi Shirakura

Publikováno v: American journal of physiology. Endocrinology and metabolism. 297(6)

Glucose ingestion stimulates the secretion of the incretin hormones, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1). Despite the critical role of incretins in glucose homeostasis, the mechanism of glucose-induced i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb704ed904dffb68bfa9600fe07d129
https://pubmed.ncbi.nlm.nih.gov/19808907

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