Výsledky vyhledávání - "Satoshi Akahane"

DNA microarray analysis of white adipose tissue from obese (fa/fa) Zucker rats treated with a β3-adrenoceptor agonist, KTO-7924

Autor: Masayuki Isaji, Akane Matsuzawa, Masuo Akahane, Toshiki Homma, Fumiki Oana, Hiroo Takeda, Satoshi Akahane

Publikováno v: Pharmacological Research. 52:395-400

We aimed to examine the effects of KTO-7924 (β3-adrenoceptor agonist) on lipid metabolism and mRNA expressions in retroperitoneal white adipose tissue (RP WAT) in obese (fa/fa) Zucker rats using DNA microarray. Oral KTO-7924 for 28 days significantl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0658d0fece27dbea69d05c5eeb85837
https://doi.org/10.1016/j.phrs.2005.05.014

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Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a β3-adrenoceptor agonist

Autor: Masayuki Isaji, Masuo Akahane, Akane Matsuzawa, Hiroo Takeda, Satoshi Akahane, Fumiki Oana

Publikováno v: European Journal of Pharmacology. 518:71-76

Our aim was to determine the effect of a β3-adrenoceptor agonist on plasma adiponectin levels and on the level of expression of mRNA for adiponectin, adiponectin receptor 1, and adiponectin receptor 2 in db/db mice. Two weeks' oral administration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4efe1edcbe7e4f377fc8b30413fffc
https://doi.org/10.1016/j.ejphar.2005.06.004

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Functional Characterization of β-adrenoceptor Subtypes in the Canine and Rat Lower Urinary Tract

Autor: Hiroshi Miyata, Masuo Akahane, Yoshinobu Yamazaki, Osamu Nishizawa, Masami Kojima, Yasuhiko Igawa, Hiroo Takeda, Kouich Kaidoh, Satoshi Akahane, Akane Matsuzawa

Publikováno v: Journal of Urology. 170:654-658

We compared the effect of a beta 3-adrenoceptor (AR) agonist with that of beta 1 and beta 2-AR agonists on the urethra and bladder in the dog and rat.In an in vitro experiment we studied the relaxant effect of subtype selective beta-AR agonists in ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b3023439da40d9cf412e073bc24817
https://doi.org/10.1097/01.ju.0000074622.50255.a8

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Evaluation of a New Blood Coagulation Factor Xa Inhibitor, KFA-1411, as an Anticoagulant in a Cynomolgus Monkey Hemodialysis Model: Parameters Suitable for Monitoring Anticoagulant Activities

Autor: Kiyoto Hara, Masami Kojima, Satoshi Akahane, Takashi Koizumi, Toshiki Honma, Yuji Hoyano, Masahiko Uchida, Masuo Akahane

Publikováno v: Journal of Health Science. 49:368-378

A Cynomolgus monkey hemodialysis model was used to evaluate the efficacy of a new factor Xa (FXa) inhibitor as an anticoagulant for hemodialysis. We tested the selective FXa inhibitor KFA-1411, using doses of 0.15 mg/ kg/hr, 0.3 mg/kg/hr, and 0.6 mg/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b3f8207a364ce89a0818547b150f893
https://doi.org/10.1248/jhs.49.368

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Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals

Autor: Masami Kojima, Takashi Koizumi, Kiyoto Hara, Atsushi Matsuzawa, Akane Matsuzawa, Masahiko Uchida, Satoshi Akahane, Toshiki Honma

Publikováno v: The Journal of Toxicological Sciences. 28:25-34

This study examined a low-molecular-weight factor-Xa inhibitor, KFA-1411 (3-[N-(3-amidinophenyl)-N-[N-[4-[1-(1-iminoethyl)piperidin-4- yl]phenyl]carbamoylmethyl]aminomethyl]phenoxyacetic acid monosulfonate-dihydrate). KFA-1411 selectively inhibited F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc4637af4c2232582bf2efa6f8e20c2
https://doi.org/10.2131/jts.28.25

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Effects of Selective β2 and β3-Adrenoceptor Agonists on Detrusor Hyperreflexia in Conscious Cerebral Infarcted Rats

Autor: Kouichi Kaidoh, Hiroshi Miyata, Satoshi Akahane, Karl-Erik Andersson, Osamu Nishizawa, Yasuhiko Igawa, Yukiyoshi Ajisawa, Hiroo Takeda, Yoshinobu Yamazaki

Publikováno v: Journal of Urology. 168:1247-1252

Purpose: We evaluated the effects of β-adrenoceptor agonists on detrusor hyperreflexia in cerebral infarcted rats.Materials and Methods: To produce cerebral infarction in Sprague-Dawley rats the left middle cerebral artery was occluded by introducin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e58f872885b33454975b590817eaa3e
https://doi.org/10.1016/s0022-5347(05)64634-4

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Effects of ?3-adrenoceptor stimulation on prostaglandin E2-induced bladder hyperactivity and on the cardiovascular system in conscious rats

Autor: Kouichi Kaidoh, Yasuhiko Igawa, Hiroshi Miyata, Karl-Erik Andersson, Yoshinobu Yamazaki, Satoshi Akahane, Osamu Nishizawa, Hiroo Takeda, Masuo Akahane

Publikováno v: Neurourology and Urodynamics. 21:558-565

Aims. To investigate the effects of selective beta(2)- and selective beta(3)-adrenoceptor (AR) agonists on prostaglandin (PG) E-2-induced bladder hyperactivity in conscious free-moving rats. Methods. Female Sprague-Dawley rats were anesthetized for i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498ebd20b9c0d6e1044e7fe93e637fab
https://doi.org/10.1002/nau.10034

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β3-Adrenoceptor agonists for the treatment of frequent urination and urinary incontinence: 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionic acid

Autor: Nobuyuki Tanaka, Akihito Hirabayashi, Masuo Akahane, Hideyuki Muranaka, Harunobu Mukaiyama, Takehiro Ishikawa, Satoshi Akahane, Tetsuro Tamai

Publikováno v: Bioorganic & Medicinal Chemistry. 9:3265-3271

In a search for novel analogues of beta(3)-adrenoceptor (AR) agonists relaxing the bladder for treatment of urinary dysfunction, 2-[4-(2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]-2-methylpropionic acids (1a-e), into w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d0bd882d9556158983a33f96ef8022
https://doi.org/10.1016/s0968-0896(01)00240-1

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Discovery of Novel N-Phenylglycine Derivatives as Potent and Selective β3-Adrenoceptor Agonists for the Treatment of Frequent Urination and Urinary Incontinence

Autor: Hideyuki Rasukasasu Azumino Muranaka, Satoshi Akahane, Harunobu Mukaiyama, Hiroshi Miyata, Masuo Akahane, Nobuyuki Tanaka, Akihito Hirabayashi, Tetsuro Tamai

Publikováno v: Journal of Medicinal Chemistry. 44:1436-1445

With a novel assay using isolated ferret detrusor to estimate beta(3)-adrenoceptor agonistic activity, we found that a series of glycine derivatives of ritodrine, a beta(2)-adrenoceptor agonist, are potent beta(3)-adrenoceptor agonists, with excellen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9860d86b1966e5acb9590bdfc6160fe1
https://doi.org/10.1021/jm000455z

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