Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Satoshi Akahane"'
Autor:
Hanada, Hiroyuki, Tatsuya, Aoyama, Satoshi, Akahane, Tanaka, Tomonari, Okura, Yoshito, Inatsu, Yu, Hashimoto, Noriaki, Takeno, Shion, Murayama, Taro, Lee, Hanju, Kojima, Shinya, Takeuchi, Ichiro
In this study, we propose a machine learning method called Distributionally Robust Safe Sample Screening (DRSSS). DRSSS aims to identify unnecessary training samples, even when the distribution of the training samples changes in the future. To achiev
Externí odkaz:
http://arxiv.org/abs/2406.05964
Autor:
Masayuki Isaji, Akane Matsuzawa, Masuo Akahane, Toshiki Homma, Fumiki Oana, Hiroo Takeda, Satoshi Akahane
Publikováno v:
Pharmacological Research. 52:395-400
We aimed to examine the effects of KTO-7924 (β3-adrenoceptor agonist) on lipid metabolism and mRNA expressions in retroperitoneal white adipose tissue (RP WAT) in obese (fa/fa) Zucker rats using DNA microarray. Oral KTO-7924 for 28 days significantl
Publikováno v:
European Journal of Pharmacology. 518:71-76
Our aim was to determine the effect of a β3-adrenoceptor agonist on plasma adiponectin levels and on the level of expression of mRNA for adiponectin, adiponectin receptor 1, and adiponectin receptor 2 in db/db mice. Two weeks' oral administration of
Autor:
Hiroshi Miyata, Masuo Akahane, Yoshinobu Yamazaki, Osamu Nishizawa, Masami Kojima, Yasuhiko Igawa, Hiroo Takeda, Kouich Kaidoh, Satoshi Akahane, Akane Matsuzawa
Publikováno v:
Journal of Urology. 170:654-658
We compared the effect of a beta 3-adrenoceptor (AR) agonist with that of beta 1 and beta 2-AR agonists on the urethra and bladder in the dog and rat.In an in vitro experiment we studied the relaxant effect of subtype selective beta-AR agonists in ca
Autor:
Kiyoto Hara, Masami Kojima, Satoshi Akahane, Takashi Koizumi, Toshiki Honma, Yuji Hoyano, Masahiko Uchida, Masuo Akahane
Publikováno v:
Journal of Health Science. 49:368-378
A Cynomolgus monkey hemodialysis model was used to evaluate the efficacy of a new factor Xa (FXa) inhibitor as an anticoagulant for hemodialysis. We tested the selective FXa inhibitor KFA-1411, using doses of 0.15 mg/ kg/hr, 0.3 mg/kg/hr, and 0.6 mg/
Autor:
Masami Kojima, Takashi Koizumi, Kiyoto Hara, Atsushi Matsuzawa, Akane Matsuzawa, Masahiko Uchida, Satoshi Akahane, Toshiki Honma
Publikováno v:
The Journal of Toxicological Sciences. 28:25-34
This study examined a low-molecular-weight factor-Xa inhibitor, KFA-1411 (3-[N-(3-amidinophenyl)-N-[N-[4-[1-(1-iminoethyl)piperidin-4- yl]phenyl]carbamoylmethyl]aminomethyl]phenoxyacetic acid monosulfonate-dihydrate). KFA-1411 selectively inhibited F
Autor:
KOUICHI KAIDOH, YASUHIKO IGAWA, HIROO TAKEDA, YOSHINOBU YAMAZAKI, SATOSHI AKAHANE, HIROSHI MIYATA, YUKIYOSHI AJISAWA, OSAMU NISHIZAWA, KARL-ERIK ANDERSSON
Publikováno v:
The Journal of Urology. :1247-1252
Autor:
Kouichi Kaidoh, Hiroshi Miyata, Satoshi Akahane, Karl-Erik Andersson, Osamu Nishizawa, Yasuhiko Igawa, Yukiyoshi Ajisawa, Hiroo Takeda, Yoshinobu Yamazaki
Publikováno v:
Journal of Urology. 168:1247-1252
Purpose: We evaluated the effects of β-adrenoceptor agonists on detrusor hyperreflexia in cerebral infarcted rats.Materials and Methods: To produce cerebral infarction in Sprague-Dawley rats the left middle cerebral artery was occluded by introducin
Autor:
Kouichi Kaidoh, Yasuhiko Igawa, Hiroshi Miyata, Karl-Erik Andersson, Yoshinobu Yamazaki, Satoshi Akahane, Osamu Nishizawa, Hiroo Takeda, Masuo Akahane
Publikováno v:
Neurourology and Urodynamics. 21:558-565
Aims. To investigate the effects of selective beta(2)- and selective beta(3)-adrenoceptor (AR) agonists on prostaglandin (PG) E-2-induced bladder hyperactivity in conscious free-moving rats. Methods. Female Sprague-Dawley rats were anesthetized for i
Autor:
Nobuyuki Tanaka, Akihito Hirabayashi, Masuo Akahane, Hideyuki Muranaka, Harunobu Mukaiyama, Takehiro Ishikawa, Satoshi Akahane, Tetsuro Tamai
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:3265-3271
In a search for novel analogues of beta(3)-adrenoceptor (AR) agonists relaxing the bladder for treatment of urinary dysfunction, 2-[4-(2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]-2-methylpropionic acids (1a-e), into w