Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Satoshi Itadani"'
Autor:
Jun Takeuchi, Tetsuya Sekiguchi, Satoshi Itadani, Shinya Takahashi, Naoya Matsumura, Atsuto Inoue, Hiromu Egashira, Yasuo Yonetomi, Yoshisuke Nakayama, Manabu Fujita, Yoshiyuki Aratani, Masaki Ima
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:2079-2097
A potent, orally available dual CysLT₁ and CysLT₂ receptor antagonist with a dicarboxylic acid is described. 4-(3-(Carboxymethyl)-4-{(E)-2-[4-(4-phenoxybutoxy)phenyl]vinyl}-1H-indol-1-yl)butanoic acid (15: ONO-4310321, IC₅₀: CysLT₁=13nM, Cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f012785de234484c040a0c11cf0c37
https://doi.org/10.1016/j.bmc.2015.03.011
https://doi.org/10.1016/j.bmc.2015.03.011
Autor:
Yoshisuke Nakayama, Yasuo Yonetomi, Akiharu Ishida, Satoshi Itadani, Akira Imagawa, Hiroaki Nomura, Junya Ueda, Katsuya Hisaichi, Kazuyuki Ohmoto, Masaki Ima, Nobukazu Ohta, Takeshi Nabe, Hiromu Egashira, Atsushi Kinoshita, Tetsuya Kitamine, Michiaki Kadode, Hideki Moriguchi, Manabu Fujita, Yoshiyuki Aratani, Tomohiko Sekioka, Kentaro Yashiro, Yohei Tajima, Yoshiyuki Yamaura, Tetsuya Sekiguchi, Takafumi Nakao, Atsuto Inoue, Naoya Matsumura, Shinya Takahashi, Jun Takeuchi
Publikováno v:
Journal of medicinal chemistry. 58(15)
An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and dicarboxylic acid moieties is described. Gemilukast (ONO-6950) was generated via isomerization of the core indole and the incorpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6528ca6d6fa73481e590b5866bf0970a
https://pubmed.ncbi.nlm.nih.gov/26200813
https://pubmed.ncbi.nlm.nih.gov/26200813
Autor:
Satoshi, Itadani, Shinya, Takahashi, Masaki, Ima, Tetsuya, Sekiguchi, Yoshiyuki, Aratani, Hiromu, Egashira, Naoya, Matsumura, Atsuto, Inoue, Yasuo, Yonetomi, Manabu, Fujita, Yoshisuke, Nakayama, Jun, Takeuchi
Publikováno v:
Bioorganicmedicinal chemistry. 23(9)
A potent, orally available dual CysLT₁ and CysLT₂ receptor antagonist with a dicarboxylic acid is described. 4-(3-(Carboxymethyl)-4-{(E)-2-[4-(4-phenoxybutoxy)phenyl]vinyl}-1H-indol-1-yl)butanoic acid (15: ONO-4310321, IC₅₀: CysLT₁=13nM, Cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1863169f98c39ed74be52a88cb5e6d5
https://pubmed.ncbi.nlm.nih.gov/25800431
https://pubmed.ncbi.nlm.nih.gov/25800431
Autor:
Masahiro Ikura, Tsuneyuki Sugiura, Shingo Nakatani, Shingo Yamamoto, Satoshi Itadani, Hiroyuki Ohno, Yoshitaka Nishita, Hiromu Habashita, Masaaki Toda, Kanji Takahashi, Koji Ogawa, Hisao Nakai
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:5402-5422
A series of N-benzoyl 4-aminobutyric acid hydroxamate analogs were synthesized and evaluated as matrix metalloproteinase inhibitors. Synthetic work was focused on the chemical modification of the 4-aminobutyric acid part using easily available starti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551385e62e39b48e1a4bcf1c126af91e
https://doi.org/10.1016/j.bmc.2006.03.032
https://doi.org/10.1016/j.bmc.2006.03.032
Autor:
Wataru Kamoshima, Takaaki Obata, Shuichi Nakazawa, Akihito Ogata, Hideaki Mori, Takashi Kondo, Hisao Nakai, Masaaki Toda, Setsuko Fujita, Kouichiro Terai, Satoshi Itadani, Yoshitaka Nishita, Hiroyuki Ohno, Nagashige Omawari, Toshiaki Matsui, Masaru Sakai, Hiroshi Tsuruta
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3787-3805
Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d76cf58d7c7613fc625075b7fc98600
https://doi.org/10.1016/s0968-0896(02)00380-2
https://doi.org/10.1016/s0968-0896(02)00380-2
Autor:
Akihito Ogata, Shuichi Nakazawa, Masaaki Toda, Masaru Sakai, Takaaki Obata, Shingo Nakatani, Takashi Kondo, Nagashige Omawari, Wataru Kamoshima, Toshiaki Matsui, Yoshitaka Nishita, Kouichiro Terai, Satoshi Itadani, Hideaki Mori, Hisao Nakai, Hiroyuki Ohno
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3757-3786
Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04590084d29770666fa5f653938f0042
https://doi.org/10.1016/s0968-0896(02)00381-4
https://doi.org/10.1016/s0968-0896(02)00381-4
Publikováno v:
Tetrahedron Letters. 43:7777-7780
A new synthetic method for an acromelic acid analog, MFPA, was developed. The key step is the photoinduced benzyl radical cyclization with excellent stereoselectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7406bc2d6565c41e0cd3eddae4ea3c9e
https://doi.org/10.1016/s0040-4039(02)01817-8
https://doi.org/10.1016/s0040-4039(02)01817-8
Autor:
Jun Takeuchi, Masaki Ima, Shinya Takahashi, Satoshi Itadani, Tetsuya Sekiguchi, Manabu Fujita, Yoshisuke Nakayama
Publikováno v:
ACS medicinal chemistry letters. 5(11)
The benzoxazine derivative, (2S)-4-(3-carboxypropyl)-8-{[4-(4-phenylbutoxy)benzoyl]amino}-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (19, ONO-2050297), was identified as the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99af675e66bc22ba29261247752d355c
https://pubmed.ncbi.nlm.nih.gov/25408836
https://pubmed.ncbi.nlm.nih.gov/25408836
Autor:
Masaru Sakai, Takaaki Obata, Akihito Ogata, Yoshitaka Nishita, Shingo Nakatani, Hisao Nakai, Hiroyuki Ohno, Masaaki Toda, Nagashige Omawari, Toshiaki Matsui, Shuichi Nakazawa, Takashi Kondo, Satoshi Itadani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:903-905
The discovery of 2-acylamino-2-phenylethyl disodium phosphates 1 and 2 as structurally novel inhibitors of TNF-α production is reported. Structure–activity relationships (SARs) are also discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abadf1b52084c0f9fe6c16cdfc9a2561
https://doi.org/10.1016/s0960-894x(02)00036-7
https://doi.org/10.1016/s0960-894x(02)00036-7
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3548e1ec8d4a4a79b7148c40248831
https://doi.org/10.1002/chin.199924114
https://doi.org/10.1002/chin.199924114