Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Autor: Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Publikováno v: eLife, Vol 12 (2024)

Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicate

Externí odkaz: https://doaj.org/article/15de117935204a21a8487997042e8094

Large or multiple pseudocysts can impede or complicate the nonsurgical treatment of pancreatolithiasis

Autor: Satoshi Yamamoto, Kazuo Inui, Yoshiaki Katano, Hironao Miyoshi, Takashi Kobayashi, Yoshihiko Tachi

Publikováno v: Fujita Medical Journal, Vol 9, Iss 2, Pp 113-120 (2023)

Objectives: We aimed to determine when a coexisting pseudocyst was likely to complicate the nonsurgical treatment of pancreatolithiasis. Methods: We treated 165 patients with pancreatolithiasis nonsurgically between 1992 and 2020, including 21 wit

Externí odkaz: https://doaj.org/article/86f0017d106c4d07b4dc43074d6ee2e9

Epidemiology of Subarachnoid Hemorrhage in Isolated Islands in Japan: A Population-based Study in the Miyako Islands

Autor: Naoki WAKUTA, Kenji FUKUDA, Masaki TAKAHARA, Satoshi YAMAMOTO, Hisatomi ARIMA, Eiji MOTONAGA, Tooru INOUE

Publikováno v: Neurologia Medico-Chirurgica, Vol 63, Iss 1, Pp 23-30 (2023)

The Miyako Islands (with a population of approximately 50,000) are located in southwestern Japan, with a subtropical oceanic climate. This isolated location permitted a retrospective population-based epidemiological study of subarachnoid hemorrhage.

Externí odkaz: https://doaj.org/article/fb019372c38b4f10b437d7050ac27b3b

CH3OH and Its Deuterated Species in the Disk/Envelope System of the Low-mass Protostellar Source B335

Autor: Yuki Okoda, Yoko Oya, Nami Sakai, Yoshimasa Watanabe, Ana López-Sepulcre, Takahiro Oyama, Shaoshan Zeng, Satoshi Yamamoto

Publikováno v: The Astrophysical Journal, Vol 970, Iss 1, p 28 (2024)

Deuterium fractionation in the closest vicinity of a protostar is important in understanding its potential heritage to a planetary system. Here, we have detected the spectral line emission of CH _3 OH and its three deuterated species, CH _2 DOH, CHD

Externí odkaz: https://doaj.org/article/a06ec167076e47a4bc8a8505129b338c

Synthetic Observations of the Infalling Rotating Envelope: Links between the Physical Structure and Observational Features

Autor: Shoji Mori, Yuri Aikawa, Yoko Oya, Satoshi Yamamoto, Nami Sakai

Publikováno v: The Astrophysical Journal, Vol 961, Iss 1, p 31 (2024)

We performed synthetic observations of the Ulrich, Cassen, and Moosman (UCM) model to understand the relation between the physical structures of the infalling envelope around a protostar and their observational features in molecular lines, adopting L

Externí odkaz: https://doaj.org/article/202fa490e1d34e418ac1cb9fc75efd55