Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Satoru Senju"'
Publikováno v:
Heliyon, Vol 6, Iss 11, Pp e05407- (2020)
Human dendritic cells (DCs) are the main target cells of dengue virus (DENV). Because humans injected with even a small volume of DENV from mosquito saliva display a high level of viremia, DCs are expected to be highly susceptible to DENV. In the pre
Externí odkaz:
https://doaj.org/article/fa67c785eb3d459c8fd206e290491a83
Autor:
Hiroaki Mashima, Rong Zhang, Tsuyoshi Kobayashi, Yuichiro Hagiya, Hirotake Tsukamoto, Tianyi Liu, Tatsuaki Iwama, Masateru Yamamoto, Chiahsuan Lin, Ryusuke Nakatsuka, Yuta Mishima, Noriko Watanabe, Takashi Yamada, Satoru Senju, Shin Kaneko, Alimjan Idiris, Tetsuya Nakatsura, Hideki Ohdan, Yasushi Uemura
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Immunotherapy using dendritic cells (DCs) is a promising treatment modality for cancer. However, the limited number of functional DCs from peripheral blood has been linked to the unsatisfactory clinical efficacies of current DC-based cancer immunothe
Externí odkaz:
https://doaj.org/article/97057ff2950a43e8858f76e78e9bec65
Autor:
Genki Suenaga, Tokunori Ikeda, Teruaki Masuda, Hiroaki Motokawa, Taro Yamashita, Kotaro Takamatsu, Yohei Misumi, Mitsuharu Ueda, Hirotaka Matsui, Satoru Senju, Yukio Ando
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The relationship between familial amyloid polyneuropathy (FAP), which is caused by mutated transthyretin (TTR), and inflammation has only recently been noted. To determine whether inflammation is present in FAP carriers and patients, serum i
Externí odkaz:
https://doaj.org/article/5dbb39c113ac4fe3a3a9ceef389c870f
Autor:
Nobuhiro Tsuchiya, Rong Zhang, Tatsuaki Iwama, Norihiro Ueda, Tianyi Liu, Minako Tatsumi, Yutaka Sasaki, Ranmaru Shimoda, Yuki Osako, Yu Sawada, Yosuke Kubo, Azusa Miyashita, Satoshi Fukushima, Zhao Cheng, Ryo Nakaki, Keiyo Takubo, Seiji Okada, Shin Kaneko, Hironobu Ihn, Tsuneyasu Kaisho, Yasuharu Nishimura, Satoru Senju, Itaru Endo, Tetsuya Nakatsura, Yasushi Uemura
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 162-175.e9 (2019)
Summary: Type I interferons (IFNs) play important roles in antitumor immunity. We generated IFN-α-producing cells by genetically engineered induced pluripotent stem cell (iPSC)-derived proliferating myeloid cells (iPSC-pMCs). Local administration of
Externí odkaz:
https://doaj.org/article/10e8ff19e2ed49ff9f9f1af0099b33bd
Autor:
Miki Tsuruta, Shohei Ueda, Poh Yin Yew, Isao Fukuda, Sachiko Yoshimura, Hiroyuki Kishi, Hiroshi Hamana, Masatoshi Hirayama, Junji Yatsuda, Atsushi Irie, Satoru Senju, Eiji Yuba, Tomomi Kamba, Masatoshi Eto, Hideki Nakayama, Yasuharu Nishimura
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
DEP domain containing 1 (DEPDC1) and M-phase phosphoprotein 1 (MPHOSPH1) are human cancer testis antigens that are frequently overexpressed in urinary bladder cancer. In a phase I/II clinical trial, a DEPDC1- and MPHOSPH1-derived short peptide vaccin
Externí odkaz:
https://doaj.org/article/a381e4ac4ae24f4b8b66f97b7ddc00da
Autor:
Koutaro Takamatsu, Tokunori Ikeda, Miwa Haruta, Keiko Matsumura, Yasuhiro Ogi, Naomi Nakagata, Makoto Uchino, Yukio Ando, Yasuharu Nishimura, Satoru Senju
Publikováno v:
Stem Cell Research, Vol 13, Iss 3, Pp 442-453 (2014)
The purpose of this study was to evaluate the therapeutic potential of human induced pluripotent stem (iPS) cell-derived macrophage-like cells for Alzheimer's disease (AD). In previous studies, we established the technology to generate macrophage-lik
Externí odkaz:
https://doaj.org/article/1b28bdbc4b354616bb6f903b6f3a3696
Autor:
Yuya Imamura, Miwa Haruta, Yusuke Tomita, Keiko Matsumura, Tokunori Ikeda, Akira Yuno, Masatoshi Hirayama, Hideki Nakayama, Hiroshi Mizuta, Yasuharu Nishimura, Satoru Senju
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152384 (2016)
We previously reported a method to expand human monocytes through lentivirus-mediated introduction of cMYC and BMI1, and we named the monocyte-derived proliferating cells, CD14-ML. CD14-ML differentiated into functional DC (CD14-ML-DC) upon addition
Externí odkaz:
https://doaj.org/article/a32997cad22043bcb23f127d278245a2
Autor:
Genki Suenaga, Tokunori Ikeda, Yoshihiro Komohara, Koutaro Takamatsu, Tatsuyuki Kakuma, Masayoshi Tasaki, Yohei Misumi, Mitsuharu Ueda, Takaaki Ito, Satoru Senju, Yukio Ando
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163944 (2016)
We hypothesized that tissue-resident macrophages in familial amyloid polyneuropathy (FAP) patients will exhibit qualitative or quantitative abnormalities, that may accelerate transthyretin (TTR)-derived amyloid deposition. To evaluate this, we examin
Externí odkaz:
https://doaj.org/article/548ab43fea164940af78119efff6aba0
Autor:
Tokunori Ikeda, Shinya Hirata, Koutaro Takamatsu, Miwa Haruta, Hirotake Tsukamoto, Takaaki Ito, Makoto Uchino, Yukio Ando, Seiho Nagafuchi, Yasuharu Nishimura, Satoru Senju
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115198 (2014)
We herein demonstrate the immune-regulatory effect of embryonic stem cell-derived dendritic cells (ES-DCs) using two models of autoimmune disease, namely non-obese diabetic (NOD) mice and experimental autoimmune encephalomyelitis (EAE). Treatment of
Externí odkaz:
https://doaj.org/article/15fc7d01a2ac4006966b51c9787fcef3
Autor:
Junji Yatsuda, Atsushi Irie, Kumiko Harada, Yayoi Michibata, Hirotake Tsukamoto, Satoru Senju, Yusuke Tomita, Akira Yuno, Masatoshi Hirayama, Mohammad Abu Sayem, Naoki Takeda, Isao Shibuya, Shinji Sogo, Fumihiro Fujiki, Haruo Sugiyama, Masatoshi Eto, Yasuharu Nishimura
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84908 (2013)
Reports have shown that activation of tumor-specific CD4(+) helper T (Th) cells is crucial for effective anti-tumor immunity and identification of Th-cell epitopes is critical for peptide vaccine-based cancer immunotherapy. Although computer algorith
Externí odkaz:
https://doaj.org/article/19d69771287a45c68392bc06b1c0c833