Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Satoru Oi"'
Autor:
Akiyoshi Tani, Yoshio Yamamoto, Takuo Kosaka, Tomoko Asakawa, Yasufumi Miyamoto, Tohru Yamashita, Yoshihiro Banno, Shigetoshi Tsubotani, Satoru Oi, Michiko Tawada, Hironobu Maezaki, Nobuhiro Suzuki, Koji Ikedo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3565-3571
We report a design strategy to obtain potent DPP-4 inhibitors by incorporating salt bridge formation with Lys554 in the S1′ pocket. By applying the strategy to the previously identified templates, quinoline 4 and pyridines 16a, 16b, and 17 have bee
Autor:
Erika Nakatani, Keita Terui, Mitsuyuki Nakata, Shugo Komatsu, Ryohei Shibata, Satoru Oita, Yunosuke Kawaguchi, Ayako Takenouchi, Sakurako Harada-Kagitani, Takashi Kishimoto, Koji Fukumoto, Tomoro Hishiki
Publikováno v:
Surgical Case Reports, Vol 9, Iss 1, Pp 1-5 (2023)
Abstract Background Laryngotracheoesophageal cleft (LTEC) is a rare disease in which the larynx and trachea communicate posteriorly to the esophagus. It is often associated with other congenital malformations, particularly gastrointestinal anomalies.
Externí odkaz:
https://doaj.org/article/f7a94c1872de4beeb90c9d1f5b5ab03e
Autor:
Masatoshi Hazama, Satoru Oi, Ken-Ichi Kuroshima, Hidenori Abe, Shigekazu Sasaki, Tomoko Urushibara, Yoshihiro Banno, Shin-ichi Matsumoto, Naohiro Taya, Nobuyuki Amano, Yasufumi Miyamoto, Saku Miyamoto, Makoto Kamata, Shin-Ichi Niwa, Masanori Watanabe, Jun Kunitomo, Akira Horinouchi, Shinichiro Matsunaga
Publikováno v:
Bioorganicmedicinal chemistry. 25(21)
The discovery of a novel series of β-methyltryptophan (β MeTrp) derivatives as selective and orally active non-peptide somatostatin receptor 2 (SSTR2) agonists for the treatment of Type 2 diabetes is described. In our previous research, Compound A,
Publikováno v:
Atmospheric Science Letters, Vol 24, Iss 6, Pp n/a-n/a (2023)
Abstract This study investigated a rainfall event under a typhoon influence using a 2D video disdrometer and weather radar observations to characterize raindrop size distribution (DSD) in a mixed convective and stratiform precipitating system. During
Externí odkaz:
https://doaj.org/article/1cf3059e6c8b4657830210bb15f3494e
Autor:
Hironobu, Maezaki, Yoshihiro, Banno, Yasufumi, Miyamoto, Yusuke, Moritoh, Yuusuke, Moritou, Tomoko, Asakawa, Osamu, Kataoka, Koji, Takeuchi, Nobuhiro, Suzuki, Koji, Ikedo, Takuo, Kosaka, Masako, Sasaki, Shigetoshi, Tsubotani, Akiyoshi, Tani, Miyuki, Funami, Yoshio, Yamamoto, Michiko, Tawada, Kathleen, Aertgeerts, Jason, Yano, Satoru, Oi
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4482-4498
Dipeptidyl peptidase IV (DPP-4) inhibition is a validated therapeutic option for type 2 diabetes, exhibiting multiple antidiabetic effects with little or no risk of hypoglycemia. In our studies involving non-covalent DPP-4 inhibitors, a novel series
Autor:
Michiko Tawada, Hironobu Maezaki, Satoru Oi, Nobuhiro Suzuki, Tomoko Asakawa, Jason Yano, Osamu Kataoka, Yoshio Yamamoto, Koji Takeuchi, Yasufumi Miyamoto, Mitsuru Sasaki, Kathleen Aertgeerts, Yoshihiro Banno, Koji Ikedo, Shigetoshi Tsubotani, Miyuki Funami, Akiyoshi Tani, Takuo Kosaka
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4953-4970
The design, synthesis, and structure-activity relationships of a new class of potent and orally active non-peptide dipeptidyl peptidase IV (DPP-4) inhibitors, 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones, are described. We hypothesized that the
Autor:
Satoru Oi
Publikováno v:
Hokengakuzasshi (JOURNAL of INSURANCE SCIENCE). 2017:636_5-636_24
Autor:
Yusuke Moritoh, Jason Yano, Shigetoshi Tsubotani, Takuo Kosaka, Yoshihiro Banno, Michiko Amano, Osamu Kataoka, Yasufumi Miyamoto, Koji Takeuchi, Masako Sasaki, Satoru Oi, Tomoko Asakawa, Nobuhiro Suzuki, Akiyoshi Tani, Hiroaki Yashiro, Yoshio Yamamoto, Hironobu Maezaki, Koji Ikedo, Miyuki Funami, Kathleen Aertgeerts, Tohru Yamashita, Tatsuhiko Fujimoto
Publikováno v:
Journal of medicinal chemistry. 54(3)
Inhibition of dipeptidyl peptidase IV (DPP-4) is an exciting new approach for the treatment of diabetes. To date there has been no DPP-4 chemotype possessing a carboxy group that has progressed into clinical trials. Originating from the discovery of
Autor:
Nobuhiro Suzuki, Osamu Kataoka, Tatsuhiko Fujimoto, Hironobu Maezaki, Shigetoshi Tsubotani, Koji Takeuchi, Akiyoshi Tani, Yasufumi Miyamoto, Yoshio Yamamoto, Takuo Kosaka, Michiko Amano, Kathleen Aertgeerts, Yusuke Moritoh, Yoshihiro Banno, Satoru Oi, Jason Yano, Tomoko Asakawa, Koji Ikedo, Miyuki Funami, Tohru Yamashita
Publikováno v:
Bioorganicmedicinal chemistry. 19(1)
We have previously discovered nicotinic acid derivative 1 as a structurally novel dipeptidyl peptidase IV (DPP-4) inhibitor. In this study, we obtained the X-ray co-crystal structure between nicotinic acid derivative 1 and DPP-4. From these X-ray co-
Publikováno v:
Journal of Flood Risk Management, Vol 15, Iss 2, Pp n/a-n/a (2022)
Abstract Predictive simulation of concurrent debris flows using only pre‐disaster information has been difficult, partly because of problems faced in predicting debris‐flow initiation locations (i.e., slope failure). However, because catchment to
Externí odkaz:
https://doaj.org/article/40ef886ad34f41b88bc400d94e7bc64a