Výsledky vyhledávání - "Satoru Iwata"

Akademický článek

Selecting molecules with diverse structures and properties by maximizing submodular functions of descriptors learned with graph neural networks

Autor: Tomohiro Nakamura, Shinsaku Sakaue, Kaito Fujii, Yu Harabuchi, Satoshi Maeda, Satoru Iwata

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)

Abstract Selecting diverse molecules from unexplored areas of chemical space is one of the most important tasks for discovering novel molecules and reactions. This paper proposes a new approach for selecting a subset of diverse molecules from a given

Externí odkaz: https://doaj.org/article/6300fb5da5e7416f8a14679d5624b273

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Akademický článek

Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals

Autor: Yuji Suehiro, Sawako Yoshina, Tomoko Motohashi, Satoru Iwata, Katsufumi Dejima, Shohei Mitani

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract With the development of massive parallel sequencing technology, it has become easier to establish new model organisms that are ideally suited to the specific biological phenomena of interest. Considering the history of research using classic

Externí odkaz: https://doaj.org/article/301ba8ccca06423d805b46c450f7433e

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Akademický článek

Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

Autor: Kota Ogawa, Akiko Noda, Jun Ueda, Takehiro Ogata, Rumiko Matsuyama, Yuji Nishizawa, Shanlou Qiao, Satoru Iwata, Morihiro Ito, Yoshitaka Fujihara, Masatoshi Ichihara, Koichi Adachi, Yuji Takaoka, Takashi Iwamoto

Publikováno v: Cellular & Molecular Biology Letters, Vol 25, Iss 1, Pp 1-21 (2020)

Abstract Background Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown to be upregulated in

Externí odkaz: https://doaj.org/article/76abded848f0474c80b7cf225597a0ef

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Akademický článek

An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain

Autor: Satoru Iwata, Takahisa Sasaki, Miki Nagahara, Takashi Iwamoto

Publikováno v: G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)

AbstractAs the efficiency of the clustered regularly interspaced short palindromic repeats/Cas system is extremely high, creation and maintenance of homozygous lethal mutants are often difficult. Here, we present an efficient in vivoiIn(6)1Jin vitroT

Externí odkaz: https://doaj.org/article/e867b2299355409bafb76b5b359982f1

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Akademický článek

Simple and large-scale chromosomal engineering of mouse zygotes via in vitro and in vivo electroporation

Autor: Satoru Iwata, Hitomi Nakadai, Daisuke Fukushi, Mami Jose, Miki Nagahara, Takashi Iwamoto

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)

Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system has facilitated dramatic progress in the field of genome engineering. Whilst microinjection of the Cas9 protein and a single guide RNA (sgRNA) into mouse zygo

Externí odkaz: https://doaj.org/article/253e25a047044934a4003b6259c44dd2

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Akademický článek

An Aneuploidy-Free and Structurally Defined Balancer Chromosome Toolkit for Caenorhabditis elegans

Autor: Katsufumi Dejima, Sayaka Hori, Satoru Iwata, Yuji Suehiro, Sawako Yoshina, Tomoko Motohashi, Shohei Mitani

Publikováno v: Cell Reports, Vol 22, Iss 1, Pp 232-241 (2018)

Summary: Balancer chromosomes are critical tools for genetic research. In C. elegans, reciprocal translocations that lead to aneuploidy have been widely used to maintain lethal and sterile mutations in stable stocks. Here, we generated a set of aneup

Externí odkaz: https://doaj.org/article/9bef06a53643476caa2e1e182ecb4fe0

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