Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Satoru, Akazawa"'
1
Akademický článek
TYK2 signaling promotes the development of autoreactive CD8+ cytotoxic T lymphocytes and type 1 diabetes
Autor: Keiichiro Mine, Seiho Nagafuchi, Satoru Akazawa, Norio Abiru, Hitoe Mori, Hironori Kurisaki, Kazuya Shimoda, Yasunobu Yoshikai, Hirokazu Takahashi, Keizo Anzai
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Tyrosine kinase 2 (TYK2), a member of the JAK family, has attracted attention as a potential therapeutic target for autoimmune diseases. However, the role of TYK2 in CD8+ T cells and autoimmune type 1 diabetes (T1D) is poorly understood. In
Externí odkaz: https://doaj.org/article/5edae9b94e074d8ca0993562feea1375
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2
Akademický článek
Living donor liver transplantation for a patient with acute liver failure following thyroid storm: a case report
Autor: Kantoku Nagakawa, Akihiko Soyama, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Takayuki Tanaka, Michi Morita, Sakaya Kuba, Tomohiko Adachi, Masaaki Hidaka, Hisamitsu Miyaaki, Satoru Akazawa, Ichiro Horie, Motohiro Sekino, Tetsuya Hara, Shinji Okano, Kazuhiko Nakao, Susumu Eguchi
Publikováno v: Surgical Case Reports, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract Background Thyroid storm can be complicated by liver dysfunction, which may occasionally progress to acute liver failure. We herein report a case of acute liver failure following thyroid storm that was treated with living donor liver transpl
Externí odkaz: https://doaj.org/article/64703e51273143d299a891aa50113f25
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3
Akademický článek
Impact of glucagon response on early postprandial glucose excursions irrespective of residual β‐cell function in type 1 diabetes: A cross‐sectional study using a mixed meal tolerance test
Autor: Ayako Ito, Ichiro Horie, Masaki Miwa, Ayaka Sako, Tetsuro Niri, Yomi Nakashima, Riyoko Shigeno, Ai Haraguchi, Shoko Natsuda, Satoru Akazawa, Akie Kamada, Atsushi Kawakami, Norio Abiru
Publikováno v: Journal of Diabetes Investigation, Vol 12, Iss 8, Pp 1367-1376 (2021)
Abstract Aims/Introduction Controlling postprandial glucose levels in patients with type 1 diabetes is challenging even under the adequate treatment of insulin injection. Recent studies showed that dysregulated glucagon secretion exacerbates hypergly
Externí odkaz: https://doaj.org/article/490d7861a65c48a0b3890e497a065f22
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4
Akademický článek
Impaired early‐phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes
Autor: Ichiro Horie, Ai Haraguchi, Ayako Ito, Aya Nozaki, Shoko Natsuda, Satoru Akazawa, Yoshitaka Mori, Takao Ando, Ai Higashijima, Yuri Hasegawa, Atsushi Yoshida, Kiyonori Miura, Hideaki Masuzaki, Atsushi Kawakami, Norio Abiru
Publikováno v: Journal of Diabetes Investigation, Vol 11, Iss 1, Pp 232-240 (2020)
Abstract Aims/Introduction The role of glucagon abnormality has recently been reported in type 2 diabetes; however, its role in gestational diabetes mellitus (GDM) is still unknown. The glucose intolerance in GDM is heterogeneous, and not all patient
Externí odkaz: https://doaj.org/article/1411a2c6d4f640c6afb4419af9cc4c0b
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5
Akademický článek
The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice
Autor: Tingting Ge, Gaurang Jhala, Stacey Fynch, Satoru Akazawa, Sara Litwak, Evan G. Pappas, Tara Catterall, Ishan Vakil, Andrew J. Long, Lisa M. Olson, Balasubramanian Krishnamurthy, Thomas W. Kay, Helen E. Thomas
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the destruction of insulin-secreting β cells by CD8+ T cells in type 1 diabetes (T1D). We previously showed that JAK1/JAK
Externí odkaz: https://doaj.org/article/39354577fa0840eea6c38e144b21a5dd
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6
Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice
Autor: Helen E. Thomas, Stacey Fynch, Balasubramanian Krishnamurthy, Tara Catterall, Satoru Akazawa, Thomas C. Brodnicki, Kate L. Graham, Claudia Selck, Thomas W.H. Kay, Chun-Ting J. Kwong, Leanne Mackin, Evan G Pappas, Andrew P. R. Sutherland, Gaurang Jhala
Publikováno v: Diabetologia. 64:878-889
Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type I IFN production in innate immune cells. A type I IFN gene signature seen before the onset of type 1 diabetes has b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cfaf809b660ae5a6174b5dc3eb53a74
https://doi.org/10.1007/s00125-020-05378-z
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9
Interferons limit autoantigen-specific CD8
Autor: Gaurang, Jhala, Balasubramanian, Krishnamurthy, Thomas C, Brodnicki, Tingting, Ge, Satoru, Akazawa, Claudia, Selck, Prerak M, Trivedi, Evan G, Pappas, Leanne, Mackin, Nicola, Principe, Erwan, Brémaud, David J, De George, Louis, Boon, Ian, Smyth, Jonathan, Chee, Thomas W H, Kay, Helen E, Thomas
Publikováno v: Cell reports. 39(4)
Interferon gamma (IFNγ) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of IFNγ is ineffective in reducing disease. We characterize islet antigen-specific T cells in non-obese diabetic (NOD) mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97fab22d01f9071dfdfc3f0f26da54e5
https://pubmed.ncbi.nlm.nih.gov/35476975
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10
Impaired early‐phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes
Autor: Hideaki Masuzaki, Ai Haraguchi, Norio Abiru, Yoshitaka Mori, Ichiro Horie, Kiyonori Miura, Ai Higashijima, Shoko Natsuda, Atsushi Yoshida, Yuri Hasegawa, Ayako Ito, Atsushi Kawakami, Takao Ando, Satoru Akazawa, Aya Nozaki
Publikováno v: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 11, Iss 1, Pp 232-240 (2020)
Aims/Introduction The role of glucagon abnormality has recently been reported in type 2 diabetes; however, its role in gestational diabetes mellitus (GDM) is still unknown. The glucose intolerance in GDM is heterogeneous, and not all patients require
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b45dbba1983c27aa06d5767989d853f
http://europepmc.org/articles/PMC6944843
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