Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Satomi Tsukahara"'
Autor:
Kazuhiro Kunimasa, Chika Ikeda-Ishikawa, Yuri Tani, Satomi Tsukahara, Junko Sakurai, Yuka Okamoto, Masaru Koido, Shingo Dan, Akihiro Tomida
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The unfolded protein response (UPR) is an adaptive stress response pathway that is essential for cancer cell survival under endoplasmic reticulum stress such as during glucose starvation. In this study, we identified spautin-1, an autophagy
Externí odkaz:
https://doaj.org/article/6b74388dd1ca4b0d81668d7c13b9b647
Autor:
Mizuki Takahashi, Yuka Okamoto, Yu Kato, Hitomi Shirahama, Satomi Tsukahara, Yoshikazu Sugimoto, Akihiro Tomida
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e14799- (2023)
Some oncoproteins along with stress kinase general control non-derepressible 2 (GCN2) can ensure the induction of activating transcription factor 4 (ATF4) to counteract amino acid deprivation; however, little is known regarding the role of the oncoge
Externí odkaz:
https://doaj.org/article/c79e9e474da244ae8424742855ede384
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: BRAF V600 mutation influences cellular signaling pathways for melanoma development. However, the role of oncogenic BRAF in adaptive stress response pathways is not fully understood. Here, we show that oncogenic BRAF plays an essential role i
Externí odkaz:
https://doaj.org/article/b2e7bdf248a94aadaac993b30e6909a6
Autor:
Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Toru Natsume, Akihiro Tomida
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112761 (2014)
Under ER stress, PKR-like ER-resident kinase (PERK) phosphorylates translation initiation factor eIF2α, resulting in repression of global protein synthesis and concomitant upregulation of the translation of specific mRNAs such as activating transcri
Externí odkaz:
https://doaj.org/article/39d30275341b41f8917e887f66f2c707
Autor:
Akihiro Tomida, Toshiki Watanabe, Masaaki Matsuura, Masaru Ushijima, Hiromichi Kondo, Shigeo Sato, Junko Sakurai, Satomi Tsukahara, Sakae Saito, Yoshinori Tsukumo, Junichi Matsuo
Biguanides, including metformin, buformin, and phenformin, are potential antitumorigenic agents and induce cell death during glucose deprivation, a cell condition that occurs in the tumor microenvironment. Here, we show that this selective killing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c8235519deec2572d4771975bfcb32
https://doi.org/10.1158/1535-7163.c.6536142
https://doi.org/10.1158/1535-7163.c.6536142
Autor:
Akihiro Tomida, Toshiki Watanabe, Masaaki Matsuura, Masaru Ushijima, Hiromichi Kondo, Shigeo Sato, Junko Sakurai, Satomi Tsukahara, Sakae Saito, Yoshinori Tsukumo, Junichi Matsuo
PDF file - 292K, hyperactivation of 4E-BP1 in UPR inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b81f438a87e45bc1e70fdd8f5f328d5
https://doi.org/10.1158/1535-7163.22499433.v1
https://doi.org/10.1158/1535-7163.22499433.v1
Publikováno v:
Biochemical and Biophysical Research Communications. 573:93-99
ATF4 is a crucial transcription factor in the integrated stress response, a major adaptive signaling pathway activated by tumor microenvironment and therapeutic stresses. BRAF inhibitors, such as vemurafenib, induce ATF4 in BRAF-mutated melanoma cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310764a2a5c321e38d75f4da9ff627bf
https://doi.org/10.1016/j.bbrc.2021.08.022
https://doi.org/10.1016/j.bbrc.2021.08.022
Autor:
Hitomi Shirahama, Yuri Tani, Satomi Tsukahara, Yuka Okamoto, Akiko Hasebe, Shingo Dan, Akihiro Tomida
Publikováno v:
Cancer Research. 83:1384-1384
Ferroptosis, one of the programmed cell deaths, is induced by accumulation of lipid peroxidation. To protect from ferroptosis, cells possess a wide range of reduction systems including glutathione peroxidase 4 (GPX4), which reduces lipid peroxides to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a7e85fc43d3c8e9dee7da0fefed4448
https://doi.org/10.1158/1538-7445.am2023-1384
https://doi.org/10.1158/1538-7445.am2023-1384
Autor:
Mizuki Takahashi, Yuka Okamoto, Yu Kato, Hitomi Shirahama, Satomi Tsukahara, Yoshikazu Sugimoto, Akihiro Tomida
Publikováno v:
Heliyon
Some oncoproteins along with stress kinase general control non-derepressible 2 (GCN2) can ensure the induction of activating transcription factor 4 (ATF4) to counteract amino acid deprivation; however, little is known regarding the role of the oncoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e3f96a47d9ccf7d7b6bf9458002a35
https://doi.org/10.2139/ssrn.4271082
https://doi.org/10.2139/ssrn.4271082
Autor:
Satomi Tsukahara, Junko Sakurai, Akihiro Tomida, Aki Furuno, Naomi Haga, Masaru Koido, Shigeo Sato, Yuri Tani
Publikováno v:
Oncotarget
// Masaru Koido 1, 2 , Naomi Haga 1 , Aki Furuno 1 , Satomi Tsukahara 1 , Junko Sakurai 1 , Yuri Tani 1 , Shigeo Sato 1 , Akihiro Tomida 1, 2 1 Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan 2 Department of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f067691ec5b0ea459a93aa3aa0b22a
https://doi.org/10.18632/oncotarget.14415
https://doi.org/10.18632/oncotarget.14415