Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Satomi Mukai"'
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13586-13598 (2023)
Abstract Background Mesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole‐genome analysis has revealed that mesothelioma is characte
Externí odkaz:
https://doaj.org/article/2e0769a87f1741069e13dff8aee89577
Autor:
Koya Suzuki, Masaki Tange, Ryota Yamagishi, Hiroyuki Hanada, Satomi Mukai, Tatsuhiro Sato, Takeshi Tanaka, Tomohiro Akashi, Kenji Kadomatsu, Tohru Maeda, Takashi Miida, Ichiro Takeuchi, Hiroshi Murakami, Yoshitaka Sekido, Yuko Murakami-Tonami
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Many genes responsible for Malignant mesothelioma (MM) have been identified as tumor suppressor genes and it is difficult to target these genes directly at a molecular level. We searched for the gene which showed synthetic lethal phenotype w
Externí odkaz:
https://doaj.org/article/e2ecf7b821284fb48949d85b470deb09
Autor:
Emi Fujibayashi, Satomi Mukai, Kosuke Torigata, Yumi Ando, Toshihiro Uchihashi, Masami Nozaki, Susumu Tanaka, Masato Okada, Mikihiko Kogo, Hiroshi Nojima, Norikazu Yabuta
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The epithelial-to-mesenchymal transition (EMT) is a critical process by which cancer cells acquire malignant features. However, the molecular mechanism and functional implications of EMT and the mesenchymal-to-epithelial transition (MET) in
Externí odkaz:
https://doaj.org/article/48e63075d1b2460fa119cc1239c057f1
Autor:
Tatsuhiro Sato, Hayao Nakanishi, Ken Akao, Maho Okuda, Satomi Mukai, Tohru Kiyono, Yoshitaka Sekido
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Malignant mesothelioma (MM) is a very aggressive tumor that develops from mesothelial cells, mainly due to asbestos exposure. MM is categorized into three major histological subtypes: epithelioid, sarcomatoid, and biphasic, with t
Externí odkaz:
https://doaj.org/article/81af084e9af34b928ccce8f17553c5ac
Publikováno v:
Heliyon, Vol 2, Iss 7 (2016)
The tumor suppressor kinases LATS1 and LATS2 (LATS1/2) regulate not only organ size through the Hippo signaling pathway, but also cell-cycle checkpoints and apoptosis via other signaling cascades. We previously reported that LATS1/2 localize to the m
Externí odkaz:
https://doaj.org/article/1f36a2b73ee54be89c590e8433a71f61
Autor:
Kosuke Torigata, Okuzaki Daisuke, Satomi Mukai, Akira Hatanaka, Fumiharu Ohka, Daisuke Motooka, Shota Nakamura, Yasuyuki Ohkawa, Norikazu Yabuta, Yutaka Kondo, Hiroshi Nojima
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158562 (2016)
LATS2, a pivotal Ser/Thr kinase of the Hippo pathway, plays important roles in many biological processes. LATS2 also function in Hippo-independent pathway, including mitosis, DNA damage response and epithelial to mesenchymal transition. However, the
Externí odkaz:
https://doaj.org/article/6f40edab93074bd6b4865dd434c936fa
Autor:
Yukihiro Nishikawa, Daisuke Okuzaki, Kohshiro Fukushima, Satomi Mukai, Shouichi Ohno, Yuki Ozaki, Norikazu Yabuta, Hiroshi Nojima
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134137 (2015)
Withaferin A (WA), a major bioactive component of the Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in multiple types of tumor cells, but the molecular mechanism underlying this cytotoxicity remains elusive. We report here t
Externí odkaz:
https://doaj.org/article/4ea88ae708914f23bba121e259a9829a
Publikováno v:
Cancer Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d398729eda2e0281b5dcbf42448febe
https://doi.org/10.1002/cam4.6056
https://doi.org/10.1002/cam4.6056
Autor:
Yoshitaka Sekido, Seisuke Hattori, Yoshio Shibagaki, Wataru Shimono, Okio Hino, Toshiyuki Kobayashi, Ken Akao, Emi Mishiro-Sato, Haruna Ikeda, Satomi Mukai, Tatsuhiro Sato
Figure S1. RHEB mRNA expression in different types of cancer. Figure S2. In vivo growth of MeT-5A mesothelial cells expressing exogenous RHEBL1. Figure S3. RHEBL1 binds to SmgGDS. Figure S4. SmgGDS knockdown suppresses the proliferation of mesothelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fa916ddf9552c092867f8fc1ebe0be
https://doi.org/10.1158/1541-7786.22526400
https://doi.org/10.1158/1541-7786.22526400
Autor:
Yoshitaka Sekido, Seisuke Hattori, Yoshio Shibagaki, Wataru Shimono, Okio Hino, Toshiyuki Kobayashi, Ken Akao, Emi Mishiro-Sato, Haruna Ikeda, Satomi Mukai, Tatsuhiro Sato
Malignant mesothelioma (MM) is an aggressive tumor that typically develops after a long latency following asbestos exposure. Although mechanistic target of rapamycin complex 1 (mTORC1) activation enhances MM cell growth, the mTORC1 inhibitor everolim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13133738cb4618d735995a4b03afe679
https://doi.org/10.1158/1541-7786.c.6545079.v1
https://doi.org/10.1158/1541-7786.c.6545079.v1