Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Satomi Miwa"'
Autor:
Tetsushi Kataura, Lucia Sedlackova, Congxin Sun, Gamze Kocak, Niall Wilson, Peter Banks, Faisal Hayat, Sergey Trushin, Eugenia Trushina, Oliver D. K. Maddocks, John E. Oblong, Satomi Miwa, Masaya Imoto, Shinji Saiki, Daniel Erskine, Marie E. Migaud, Sovan Sarkar, Viktor I. Korolchuk
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-13 (2024)
Abstract Impairment of autophagy leads to an accumulation of misfolded proteins and damaged organelles and has been implicated in plethora of human diseases. Loss of autophagy in actively respiring cells has also been shown to trigger metabolic colla
Externí odkaz:
https://doaj.org/article/5f963d5a91c847e89f73c916ea6f3cee
Autor:
Neda Mokhberian, Kazem Sharifi, Ehsan Soleimaninejadian, Mohamad Eftekhary, Seyed Mahmoud Hashemi, Shohreh Farhadi, Satomi Miwa, Hossein Ghanbarian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract SIRT1, a known regulator of cellular senescence, is a therapeutic target for age related disorders and its upregulation is a strategy to improve the cell therapeutic potentials of human mesenchymal stem cell (MSCs). Knockdown of natural anti
Externí odkaz:
https://doaj.org/article/ffa1884071cc498fb0aef044f5b2c5d9
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membra
Externí odkaz:
https://doaj.org/article/78add823755d4c33b3a46f6086539750
Autor:
Edward Fielder, Tengfei Wan, Ghazaleh Alimohammadiha, Abbas Ishaq, Evon Low, B Melanie Weigand, George Kelly, Craig Parker, Brigid Griffin, Diana Jurk, Viktor I Korolchuk, Thomas von Zglinicki, Satomi Miwa
Publikováno v:
eLife, Vol 11 (2022)
Cancer survivors suffer from progressive frailty, multimorbidity, and premature morbidity. We hypothesise that therapy-induced senescence and senescence progression via bystander effects are significant causes of this premature ageing phenotype. Acco
Externí odkaz:
https://doaj.org/article/f0753cffc75f40b89161b517a1c14968
Autor:
Neda Mokhberian, Kazem Sharifi, Ehsan Soleymaninejadian, Mohamad Eftekhary, Seyed Mahmoud Hashemi, Shohreh Farhadi, Satomi Miwa, Hossein Ghanbarian
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d49eb128f1c94aa4b088624c1998d667
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 683-692 (2019)
Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline. In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it blocks tumour growth. However, this is frequently incomplete,
Externí odkaz:
https://doaj.org/article/ca5af0af723e4a72bf1450fd388e66bd
Autor:
Deborah Cornell, Satomi Miwa, Merilin Georgiou, Scott James Anderson, Minna Honkanen-Scott, James A. M. Shaw, Catherine Arden
Publikováno v:
Cells, Vol 11, Iss 15, p 2330 (2022)
Appropriate glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells is an essential component of blood glucose homeostasis. Configuration of β-cells as 3D pseudoislets (PI) improves the GSIS response compared to 2D monolayer (ML) culture.
Externí odkaz:
https://doaj.org/article/e158b11719414ff5a580a555dd3350ad
Publikováno v:
EBioMedicine, Vol 21, Iss C, Pp 7-13 (2017)
Cell senescence is increasingly recognized as a major contributor to the loss of health and fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; oxidative phosphorylation efficiency is decreased and reactive oxygen sp
Externí odkaz:
https://doaj.org/article/77961f5ab6c542a4b5df518d5b40849f
Autor:
Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L. Wilson, Albert Lahat, Christoper P. Day, Alastair Burt, Allyson Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Non-alcoholic fatty liver disease is more common among older individuals. Here, the authors show that senescent cells in the liver promote fat accumulation and steatosis in the liver, and that clearance of senescent cells reduces hepatic steatosis in
Externí odkaz:
https://doaj.org/article/59da7366bd92469288a45b90a4b396f9
Autor:
Satomi Miwa, Gabriele Saretzki
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 3, Pp 358-361 (2017)
Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent RNA component. Additionally, the protein part TERT (Telomerase Reverse Transcriptase) has various non-canonical functions. For example, it can localiz
Externí odkaz:
https://doaj.org/article/29fb26f6401244b2a95897ee1720b288