Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Satoki Imai"'
Autor:
Shun Hayashi, Yoshihiro Kato, Wataru Hirose, Kohzo Yoshida, Maiko Kitaichi, Kohei Hoshino, Makoto Takata, Itaru Natsutani, Satoki Imai, Yukiyo Arai
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(18)
We describe here the design, synthesis and characterization of a series of 4,5,6,7-tetrahydrooxazolo[4,5- c ]pyridines as metabotropic glutamate receptor (mGluR) 5 negative allosteric modulators (NAMs). Optimization of the substituents led to the ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03617f634b1ce85561cc71267b92ba0b
https://pubmed.ncbi.nlm.nih.gov/28838696
https://pubmed.ncbi.nlm.nih.gov/28838696
Autor:
Takeshi Kunimatsu, Atsushi Yabunaka, Satoki Imai, Noriko Okahashi, Masashi Yabuki, Yohei Nishizato
Publikováno v:
Toxicology in Vitro. 28:397-402
SMP-028 is a new compound for treatment of asthma. Oral administration of SMP-028 to rats was associated with toxicological events in endocrine organs. These events mainly consisted of pathological changes in the adrenal gland, testis, prostate, semi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4af09e5f6b778144b0ea3be1aa28d0
https://doi.org/10.1016/j.tiv.2013.12.005
https://doi.org/10.1016/j.tiv.2013.12.005
Autor:
Sotaro Naoi, Hiroyuki Kusuhara, Yuri Tsuruya, Sho Nishida, Yuichi Sugiyama, Ryota Kikuchi, Satoki Imai
Publikováno v:
Pharmaceutical Research. 30:2880-2890
The expression of a multispecific organic anion transporter, OATP1B3/SLCO1B3, is associated with clinical prognosis and survival of cancer cells. The aims of present study were to investigate the involvement of epigenetic regulation in mRNA expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3261b3d6c7c15ea5f4e8a8719fcc3f8d
https://doi.org/10.1007/s11095-013-1117-1
https://doi.org/10.1007/s11095-013-1117-1
Autor:
Momoe Kassai, Makoto Takata, Wataru Hirose, Kohzo Yoshida, Satoki Imai, Takayoshi Yamamoto, Shun Hayashi, Yukiyo Arai, Yoshihiro Kato
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(16)
The design, synthesis and SAR studies of novel 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators (NAMs) are presented in this letter. Starting from a HTS hit compound (1, IC50=477nM), opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e88d41a2a66ab3df07487247a3d766e
https://pubmed.ncbi.nlm.nih.gov/27432763
https://pubmed.ncbi.nlm.nih.gov/27432763
Publikováno v:
Drug Metabolism and Disposition. 41:72-78
Organic anion transporting polypeptides (rodents, Oatps; human, OATPs) are primarily involved in the transmembrane transportation of a wide range of endogenous and exogenous compounds. Multiple mouse Oatp1 isoforms are closely located on chromosome 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb34fd9e07d584e0255e9174007cf68
https://doi.org/10.1124/dmd.112.047969
https://doi.org/10.1124/dmd.112.047969
Publikováno v:
Arzneimittelforschung. 59:461-470
AmBisome, a liposomal formulation of amphotericin B (CAS 1397-89-3, L-AMB), shows different pharmacokinetics from the conventional formulation, amphotericin B deoxycholate (D-AMB). To characterize the clearance process of L-AMB, the form in which it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0711c07600a9e06eef840f55809457b8
https://doi.org/10.1055/s-0031-1296426
https://doi.org/10.1055/s-0031-1296426
Autor:
Koji Chiba, Kouta Toshimoto, Satoki Imai, Yuichi Sugiyama, Yuka Hirai, Yutaka Akiyama, Makiko Kusama, Kazuya Maeda
Publikováno v:
Drug Metabolism and Disposition. 38(no. 8):1362-1370
Predicting major clearance pathways of drugs is important in understanding their pharmacokinetic properties in clinical use, such as drug-drug interactions and genetic polymorphisms, and their subsequent pharmacological/toxicological effects. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0151c861a2dd7154d571f39dfe080b23
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100622415
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100622415
Publikováno v:
Molecular Pharmacology. 75:568-576
Tissue-specific expression of transporters is tightly linked with their physiological functions through the regulation of the membrane transport of their substrates. We hypothesized that epigenetic regulation underlies the tissue-specific expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67aa1f2dc8a6e0bb60653ac5c26243b
https://doi.org/10.1124/mol.108.052589
https://doi.org/10.1124/mol.108.052589
Publikováno v:
Biopharmaceutics & Drug Disposition. 28:517-525
It is possible that SMP-797 will be administered frequently in combination with statins to hyperlipidemic patients. OATP1B1 is thought to be the major transporter that mediates the hepatic uptake of statins. This study investigated whether SMP-797 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb8bbaaf4909a6ad33020cdf630cedd
https://doi.org/10.1002/bdd.581
https://doi.org/10.1002/bdd.581
Autor:
Noriko Okahashi, Kaoru Kikuchi, Yohei Nishizato, Masashi Yabuki, Takeshi Kunimatsu, Atsushi Yabunaka, Satoki Imai
Publikováno v:
Toxicology and applied pharmacology. 276(3)
SMP-028 is a drug candidate developed for the treatment of asthma. In a 13-week repeated dose toxicity study of SMP-028 in rats and monkeys, differences of endocrine toxicological events between rats and monkeys were observed. In rats, these toxicolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046a93bd1f1088a392be293b7d19738c
https://pubmed.ncbi.nlm.nih.gov/24593921
https://pubmed.ncbi.nlm.nih.gov/24593921