Výsledky vyhledávání - "Satoki, Nakamura"

Human-Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy

Publikováno v: Circulation: Genomic and Precision Medicine. 15

Background: The Δ160E mutation in TNNT2 , which encodes troponin T, is a rare pathogenic variant identified in patients with hypertrophic cardiomyopathy and is associated with poor prognosis. Thus, a convenient human model recapitulating the patholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d2ed6e42bde8f462cb65ec9693c182b
https://doi.org/10.1161/circgen.121.003522

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Defective repair capacity of variant proteins of the DNA glycosylase NTHL1 for 5-hydroxyuracil, an oxidation product of cytosine

Autor: Hisami Kato, Hong Tao, Masanori Goto, Yuichi Kawanishi, Katsuhiro Yoshimura, Satoki Nakamura, Haruhiko Sugimura, Kazuya Shinmura, Kiyoshi Misawa

Publikováno v: Free Radical Biology and Medicine. 131:264-273

The NTHL1 gene encodes DNA glycosylase, which is involved in base excision repair, and biallelic mutations of this gene result in NTHL1-associated polyposis (NAP), a hereditary disease characterized by colorectal polyposis and multiple types of carci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b553ada233cb66563bbf925147161d3
https://doi.org/10.1016/j.freeradbiomed.2018.12.010

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Phenotypic recapitulation and correction of desmoglein-2-deficient cardiomyopathy using human-induced pluripotent stem cell-derived cardiomyocytes

Autor: Yasushi Sakata, Emiko Ito, Yasuaki Kohama, Yoshihiko Ikeda, Takumi Kondo, Tomoka Tabata, Shungo Hikoso, Mikio Shiba, Shigeru Miyagawa, Hiroyuki Inoue, Li Liu, Maki Takeda, Junjun Li, Seiji Takashima, Shuichiro Higo, Satoshi Kameda, Yoshiki Sawa, Satoki Nakamura

Publikováno v: Human Molecular Genetics

Desmoglein-2, encoded by DSG2, is one of the desmosome proteins that maintain the structural integrity of tissues, including heart. Genetic mutations in DSG2 cause arrhythmogenic cardiomyopathy, mainly in an autosomal dominant manner. Here, we identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ba52a7ad8c78aca7eb7fc82163af65
https://pubmed.ncbi.nlm.nih.gov/33949662

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Adeno-associated virus-mediated gene delivery promotes S-phase entry-independent precise targeted integration in cardiomyocytes

Autor: Seiji Takashima, Daisuke Okuzaki, Satoki Nakamura, Yasushi Sakata, Takamaru Ishizu, Satoshi Kameda, Shungo Hikoso, Tomoaki Higo, Yasuaki Kohama, Takumi Kondo, Tomoka Tabata, Shigeru Miyagawa, Mikio Shiba, Yuki Masumura, Hiroyuki Inoue, Yoshiki Sawa, Shuichiro Higo, Daisuke Motooka

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Post-mitotic cardiomyocytes have been considered to be non-permissive to precise targeted integration including homology-directed repair (HDR) after CRISPR/Cas9 genome editing. Here, we demonstrate that direct delivery of large amounts of transgene e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4897e325db950a1c486f64fc32960f
http://europepmc.org/articles/PMC7501291

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Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes

Publikováno v: Stem cell reports. 17(2)

Loss-of-function mutations in PKP2, which encodes plakophilin-2, cause arrhythmogenic cardiomyopathy (AC). Restoration of deficient molecules can serve as upstream therapy, thereby requiring a human model that recapitulates disease pathology and prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bb276f9816ff819edb8fc2d21693f1
https://pubmed.ncbi.nlm.nih.gov/35063130

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Akademický článek

Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.

Autor: Satoki Nakamura, Yasuyuki Nagata, Lin Tan, Tomonari Takemura, Kiyoshi Shibata, Michio Fujie, Shinya Fujisawa, Yasutaka Tanaka, Mitsuo Toda, Reiko Makita, Kenji Tsunekawa, Manabu Yamada, Mayumi Yamaoka, Junko Yamashita, Kazunori Ohnishi, Mitsuji Yamashita

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e28011 (2011)

The immediately-early response gene 5 (IER5) has been reported to be induced by γ-ray irradiation and to play a role in the induction of cell death caused by radiation. We previously identified IER5 as one of the 2,3,4-tribromo-3-methyl-1-phenylphos

Externí odkaz: https://doaj.org/article/f162a3b53d8940129ebf52cae39d9851

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Mutation Spectrum Induced by 8-Bromoguanine, a Base Damaged by Reactive Brominating Species, in Human Cells

Autor: Satoki Nakamura, Hisami Kato, Masanori Goto, Haruki Yoshida, Emi Tsuzaki, Yusuke Inoue, Haruhiko Sugimura, Kazuya Shinmura, Hong Tao

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)

To date, the types of mutations caused by 8-bromoguanine (8BrG), a major base lesion induced by reactive brominating species during inflammation, in human cells and the 8BrG repair system remain largely unknown. In this study, we performed asupFforwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afce606b2c5e72140a4c0870ff14c580
https://doi.org/10.1155/2017/7308501

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Functional Evaluation of Nine Missense-Type Variants of the Human DNA Glycosylase Enzyme MUTYH in the Japanese Population

Autor: Haruhiko Sugimura, Hong Tao, Hidetaka Yamada, Kazuya Shinmura, Hisami Kato, Masanori Goto, Satoki Nakamura

Publikováno v: Human Mutation. 37:350-353

Biallelic germline mutations of MUTYH, the gene encoding DNA glycosylase, cause MUTYH-associated polyposis (MAP), characterized by multiple colorectal adenomas and carcinoma(s). However, a considerable number of MUTYH variants are still functionally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc6f854ac51a99e66b0a6032e787aca
https://doi.org/10.1002/humu.22949

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