Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Satish K. Nandakumar"'
Autor:
Derek W. Brown, Liam D. Cato, Yajie Zhao, Satish K. Nandakumar, Erik L. Bao, Eugene J. Gardner, Aubrey K. Hubbard, Alexander DePaulis, Thomas Rehling, Lei Song, Kai Yu, Stephen J. Chanock, John R. B. Perry, Vijay G. Sankaran, Mitchell J. Machiela
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Clonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic clones—can differ in frequency and cellular fitness by CH type (e.g., mutations in driver genes (CHIP), gains/losses and copy-neutral loss of chromosomal segments (
Externí odkaz:
https://doaj.org/article/77165817170e4e85a1c42338d2c3eefb
Autor:
Yong Shen, Jeffrey M. Verboon, Yuannyu Zhang, Nan Liu, Yoon Jung Kim, Samantha Marglous, Satish K. Nandakumar, Richard A. Voit, Claudia Fiorini, Ayesha Ejaz, Anindita Basak, Stuart H. Orkin, Jian Xu, Vijay G. Sankaran
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Genetic mechanisms underlying fetal hemoglobin (HbF) regulation and switching are not fully understood. Here, the authors develop a single-cell genome editing functional assay to model how effects of mutation-harbouring functional elements contribute
Externí odkaz:
https://doaj.org/article/6510aaea4b7a4bf494e21f0d26b79c2e
Autor:
Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Satish K. Nandakumar, Christoph Muus, Jacob C. Ulirsch, Kaitavjeet Chowdhary, Jason D. Buenrostro, Narla Mohandas, Xiuli An, Martin J. Aryee, Aviv Regev, Vijay G. Sankaran
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3228-3240.e7 (2019)
Summary: Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This process is also of considerable interest for better understanding anemias and identifying new therapies. Here, we apply deep transcriptomic and accessibl
Externí odkaz:
https://doaj.org/article/6398f2df4d4c4128b606c247249494a4
Autor:
Satish K Nandakumar, Sean K McFarland, Laura M Mateyka, Caleb A Lareau, Jacob C Ulirsch, Leif S Ludwig, Gaurav Agarwal, Jesse M Engreitz, Bartlomiej Przychodzen, Marie McConkey, Glenn S Cowley, John G Doench, Jaroslaw P Maciejewski, Benjamin L Ebert, David E Root, Vijay G Sankaran
Publikováno v:
eLife, Vol 8 (2019)
Genome-wide association studies (GWAS) have identified thousands of variants associated with human diseases and traits. However, the majority of GWAS-implicated variants are in non-coding regions of the genome and require in depth follow-up to identi
Externí odkaz:
https://doaj.org/article/09881636b6d7446194ad63718568b54a
Autor:
Derek W. Brown, Liam D. Cato, Yajie Zhao, Satish K. Nandakumar, Erik L. Bao, Eugene J. Gardner, Alexander DePaulis, Thomas Rehling, Lei Song, Kai Yu, Stephen J. Chanock, John R. B. Perry, Vijay G. Sankaran, Mitchell J. Machiela
Clonal hematopoiesis (CH) – age-related expansion of mutated hematopoietic clones – can differ in frequency and cellular fitness. Descriptive studies have identified a spectrum of events (coding mutations in driver genes (CHIP), gains/losses and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce7881492d39986018f7d615f924ad12
https://doi.org/10.1101/2022.03.14.483644
https://doi.org/10.1101/2022.03.14.483644
Autor:
Leonard I. Zon, Roby Joehanes, Eirini Trompouki, Stephen J. Chanock, Alireza Ghamari, Min-Lee Yang, Song Yang, Seraj N. Grimes, Sierra Tseng, Michael Superdock, Daniel E. Bauer, Divya S. Vinjamur, Victoria Chan, Karen Hoi, Richard A. Young, Sonja Boatman, Teresa V. Bowman, Avik Choudhuri, Brian J. Abraham, John L. Rinn, Santhi K. Ganesh, Alan B. Cantor, Kian Hong Kock, Audrey Sporrij, Barbara Hummel, William Mallard, Paul S. Albert, Asher Lichtig, Yi Zhou, Satish K. Nandakumar, Shinichiro Takahashi, Martha L. Bulyk, Leandro M. Colli
Publikováno v:
Nature Genetics
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nat Genet
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nat Genet
Genome-wide association studies identify genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell-type-specific enhancers, but the molecular mechanisms governing phenotypic variation are less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55bc07dd03b947724044bec1c014c8e
https://doi.org/10.1038/s41588-020-00738-2
https://doi.org/10.1038/s41588-020-00738-2
Autor:
Alan B. Cantor, Inga Hofmann, Vijay G. Sankaran, David A. Williams, Dilnar Mahmut, Mitsutoshi Nakamura, Amy E. Geddis, Nour J. Abdulhay, Susan M. Parkhurst, Jeffrey M. Verboon, Becky Manes, Haydar Frangoul, Stacey Gabriel, Ah Ram Kim, Genevieve M. Crane, Daryl E. Klein, Thomas E. Akie, Namrata Gupta, Meghan E. Kapp, Satish K. Nandakumar
Publikováno v:
Journal of Clinical Immunology
Studies of genetic blood disorders have advanced our understanding of the intrinsic regulation of hematopoiesis. However, such genetic studies have only yielded limited insights into how interactions between hematopoietic cells and their microenviron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79866655865f066a6366d6919aeb3966
http://europepmc.org/articles/PMC7253386
http://europepmc.org/articles/PMC7253386
Autor:
Richard A. Voit, Liming Tao, Fulong Yu, Liam D. Cato, Blake Cohen, Travis J. Fleming, Mateusz Antoszewski, Xiaotian Liao, Claudia Fiorini, Satish K. Nandakumar, Lara Wahlster, Kristian Teichert, Aviv Regev, Vijay G. Sankaran
Publikováno v:
Nature immunology.
The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. Here, we have studied a rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc08efefa5ab14d56c1d9471c20c1ac
https://pubmed.ncbi.nlm.nih.gov/36522544
https://pubmed.ncbi.nlm.nih.gov/36522544
Autor:
Richard A. Voit, Liming Tao, Fulong Yu, Liam D. Cato, Blake Cohen, Xiaotian Liao, Claudia Fiorini, Satish K. Nandakumar, Lara Wahlster, Kristian Teichert, Aviv Regev, Vijay G. Sankaran
The molecular regulation of human hematopoietic stem cell (HSC) self-renewal and maintenance is of substantial interest, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. To better disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee19c02c5492fa70049e6ea738e324ed
https://doi.org/10.1101/2021.12.09.471942
https://doi.org/10.1101/2021.12.09.471942
Autor:
Nan Liu, Jian Xu, Stuart H. Orkin, Anindita Basak, Claudia Fiorini, Samantha Marglous, Vijay G. Sankaran, Satish K. Nandakumar, Yoon Jung Kim, Yuannyu Zhang, Richard A. Voit, Ayesha Ejaz, Yong Shen, Jeffrey M. Verboon
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Key mechanisms of fetal hemoglobin (HbF) regulation and switching have been elucidated through studies of human genetic variation, including mutations in the HBG1/2 promoters, deletions in the β-globin locus, and variation impacting BCL11A. While th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978c47c01868a32ffcc40bae3b340f70
https://pubmed.ncbi.nlm.nih.gov/34404810
https://pubmed.ncbi.nlm.nih.gov/34404810