Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Satish A. Eraly"'
Autor:
Satish A Eraly
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97734 (2014)
Microarray analyses of gene knockouts have traditionally focused on the identification of genes whose mean expression is different in knockout and wild-type mice. However, recent work suggests that changes in the variability of gene expression can ha
Externí odkaz:
https://doaj.org/article/448ec8a932344ace81620cd3e1800095
Publikováno v:
Biochemistry and Biophysics Reports
URAT1 (slc22a12) was identified as the transporter responsible for renal reabsorption of the medically important compound, uric acid. However, subsequent studies have indicated that other transporters make contributions to this process, and that URAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f18cd52bc9c3fbaf2cae73e850ed88
Autor:
Bernhard O. Palsson, Sanjay K. Nigam, Kevin T. Bush, Satish A. Eraly, Wei Wu, Henry C. Liu, Neema Jamshidi
Publikováno v:
Drug Metabolism and Disposition. 41:1825-1834
Multispecific drug transporters of the solute carrier and ATP-binding cassette families are highly conserved through evolution, but their true physiologic role remains unclear. Analyses of the organic anion transporter 3 (OAT3; encoded by Slc22a8/Oat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a34f75560e91383b2fcbcb4d8c1ce95
https://doi.org/10.1124/dmd.113.052647
https://doi.org/10.1124/dmd.113.052647
Autor:
Megha Nagle, Satish A. Eraly, Maria Gerasimova, Travis Smith, Kumar Sharma, Volker Vallon, Sanjay K. Nigam, Michael Rose, Naohiko Anzai, Satish Ramachandra Rao, Timo Rieg
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F1293-F1299
Tubular secretion of the organic cation, creatinine, limits its value as a marker of glomerular filtration rate (GFR) but the molecular determinants of this pathway are unclear. The organic anion transporters, OAT1 and OAT3, are expressed on the baso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f240e82d9647fa4bcdd4cb4c82f763e4
https://doi.org/10.1152/ajprenal.00013.2012
https://doi.org/10.1152/ajprenal.00013.2012
Autor:
Felix K. Yam, Satish A. Eraly
Publikováno v:
American Journal of Health-System Pharmacy. 69:217-220
Purpose A possible case of moxifloxacin-induced syndrome of inappropriate antidiuretic hormone (SIADH) is reported. Summary A 66-year-old Caucasian woman with stage II chronic obstructive pulmonary disease (COPD) arrived at the emergency department f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45e3492cb7cf4f60787454145c8d6cb
https://doi.org/10.2146/ajhp110201
https://doi.org/10.2146/ajhp110201
Autor:
Megha Nagle, Sanjay K. Nigam, Wei Wu, Satish A. Eraly, Sun-Young Ahn, David M. Truong, Ankur V. Dnyanmote
Publikováno v:
Journal of Biological Chemistry. 286:243-251
The organic anion transporters OAT1 (SLC22A6, originally identified by us as NKT) and OAT3 (SLC22A8) are critical for handling many toxins, metabolites, and drugs, including antivirals (Truong, D. M., Kaler, G., Khandelwal, A., Swaan, P. W., and Niga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb12649555b49e5949cbcd58e0a6090c
https://doi.org/10.1074/jbc.m110.139949
https://doi.org/10.1074/jbc.m110.139949
Publikováno v:
Physiological Genomics. 38:116-124
When the organic anion transporter Oat1 was first identified as NKT (Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, Nigam SK. J Biol Chem 272: 6471–6478, 1997), it was argued that it, together with Oct1, may be part of a larger subfamily (now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73d06a20b87ee99d84ec450d3e15c9a
https://doi.org/10.1152/physiolgenomics.90309.2008
https://doi.org/10.1152/physiolgenomics.90309.2008
Autor:
Satish A. Eraly
Publikováno v:
Pharmacological Research. 58:257-261
Hypertension is an exceedingly common disease with potentially devastating complications. Unfortunately, existing treatments are often only partially effective, indicating the utility of the development of novel therapeutics. It has recently been dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af28857c3a769c896967c7b38205fb9
https://doi.org/10.1016/j.phrs.2008.09.013
https://doi.org/10.1016/j.phrs.2008.09.013
Autor:
Sanjay K. Nigam, Gregory Kaler, Wei Wu, Timo Rieg, Volker Vallon, Sushil K. Mahata, Gary Siuzdak, Satish A. Eraly, Sun-Young Ahn, William R. Wikoff, Bruce A. Barshop, Nitish R. Mahapatra, Jon A. Gangoiti, David M. Truong
Publikováno v:
Journal of the American Society of Nephrology. 19:1732-1740
Renal organic anion transporters (OAT) are known to mediate the excretion of many drugs, but their function in normal physiology is not well understood. In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a771a1df90f4eff5789ce5c620f1d6f
https://doi.org/10.1681/asn.2008020180
https://doi.org/10.1681/asn.2008020180
Autor:
Megha Nagle, Peter W. Swaan, David M. Truong, Akash Khandelwal, Satish A. Eraly, Gregory Kaler, Sanjay K. Nigam
Publikováno v:
Journal of Biological Chemistry. 282:23841-23853
Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c526d60502799f399e038f40d451be42
https://doi.org/10.1074/jbc.m703467200
https://doi.org/10.1074/jbc.m703467200