Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sathyaseelan S Deepa"'
Autor:
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Jr., Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102550- (2023)
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase (MnSOD) using a neuron specific Cre
Externí odkaz:
https://doaj.org/article/81eb975c107342e8860817ab0704bc01
Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma
Autor:
Mundanattu Swetha, Chenicheri K. Keerthana, Tennyson P. Rayginia, Lekshmi R. Nath, Nair Hariprasad Haritha, Anwar Shabna, Kalishwaralal Kalimuthu, Arun K. Thangarasu, Sreekumar U. Aiswarya, Somaraj Jannet, Sreekumar Pillai, Kuzhuvelil B. Harikumar, Sankar Sundaram, Nikhil Ponnoor Anto, Dee H. Wu, Ravi S. Lankalapalli, Rheal Towner, Noah Isakov, Sathyaseelan S. Deepa, Ruby John Anto
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 636 (2022)
We previously reported the remarkable potency of uttroside B (Utt-B), saponin-isolated and characterized in our lab from Solanum nigrum Linn, against HCC. Recently, the U.S. FDA approved Utt-B as an ‘orphan drug’ against HCC. The current study va
Externí odkaz:
https://doaj.org/article/b186c71c587e4df097a4a4b437a83fd0
Autor:
Yiqiang Zhang, Archana Unnikrishnan, Sathyaseelan S. Deepa, Yuhong Liu, Yan Li, Yuji Ikeno, Danuta Sosnowska, Holly Van Remmen, Arlan Richardson
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 30-37 (2017)
In contrast to other mouse models that are deficient in antioxidant enzymes, mice null for Cu/Zn-superoxide dismutase (Sod1−/− mice) show a major decrease in lifespan and several accelerated aging phenotypes. The goal of this study was to determi
Externí odkaz:
https://doaj.org/article/390d6b68054645dfa11aeef78231ca4f
Autor:
Sabira Mohammed, Nidheesh Thadathil, Phoebe Ohene-Marfo, Albert L. Tran, Michael Van Der Veldt, Constantin Georgescu, Sangphil Oh, Evan H. Nicklas, Dawei Wang, Nair Hariprasad Haritha, Wenyi Luo, Ralf Janknecht, Benjamin F. Miller, Jonathan D. Wren, Willard M. Freeman, Sathyaseelan S. Deepa
Publikováno v:
Molecular Cancer Research.
Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators of HCC. Since necroptosis is a cell death pathway that induces inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb369dfd6959633eac83e70b2262a747
https://doi.org/10.1158/1541-7786.mcr-22-0820
https://doi.org/10.1158/1541-7786.mcr-22-0820
Autor:
Evan H Nicklas, Nidheesh Thadathil, Sabira Mohammed, Arlan Richardson, Sathyaseelan S. Deepa, Tommy L. Lewis
Publikováno v:
GeroScience
Chronic inflammation of the central nervous system (CNS), termed neuroinflammation, is a hallmark of aging and a proposed mediator of cognitive decline associated with aging. Neuroinflammation is characterized by the persistent activation of microgli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a398b7298385069fae16c6b5bb3fb811
https://doi.org/10.1007/s11357-021-00448-5
https://doi.org/10.1007/s11357-021-00448-5
Autor:
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen
Publikováno v:
Redox biology. 59
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase (MnSOD) using a neuron specific Cre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28422549922b2ae9379aa3618d8b536
https://pubmed.ncbi.nlm.nih.gov/36470129
https://pubmed.ncbi.nlm.nih.gov/36470129
Autor:
Sabira Mohammed, Nidheesh Thadathil, Albert L Tran, Michael Van Der Veldt, Constantin Georgescu, Nair H Haritha, Phoebe Ohene-Marfo, Sangphil Oh, Evan H Nicklas, Dawei Wang, Wenyi Luo, Ralf Janknecht, Benjamin F Miller, Jonathan D. Wren, Willard Freeman, Sathyaseelan S Deepa
Background & AimsNonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators of HCC. As necroptosis is a cell death pathway that induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78c4854d60767a3d2ad6b510627e361c
https://doi.org/10.1101/2022.08.03.502666
https://doi.org/10.1101/2022.08.03.502666
Autor:
Evan H Nicklas, Nidheesh Thadathil, Dawei Wang, Arlan Richardson, Sabira Mohammed, Sathyaseelan S. Deepa, Benjamin F. Miller, Ramasamy Selvarani
Publikováno v:
Aging Cell
Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a hallmark of aging and is strongly associated with various age‐related diseases, including chronic liver disease (CLD) and hepatocellular carcinoma (HCC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccae012b566d8cb5892b4c72e1a92f97
https://pubmed.ncbi.nlm.nih.gov/34761505
https://pubmed.ncbi.nlm.nih.gov/34761505
Autor:
Benjamin F. Miller, Nidheesh Thadathil, Sabira Mohammed, Sathyaseelan S. Deepa, Dawei Wang, Arlan Richardson, Evan H Nicklas, Ramasamy Selvarani
Inflammaging, characterized by an increase in low-grade chronic inflammation with age, is a hallmark of aging and is strongly associated with various age-related diseases, including chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Beca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eee1e01694645161208035db44fa1d3
https://doi.org/10.1101/2021.09.19.460953
https://doi.org/10.1101/2021.09.19.460953
Publikováno v:
GeroScience. 41:795-811
An age-associated increase in chronic, low-grade sterile inflammation termed “inflammaging” is a characteristic feature of mammalian aging that shows a strong association with occurrence of various age-associated diseases. However, the mechanism(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f311146b88f47043c6a735e750a50ca9
https://doi.org/10.1007/s11357-019-00131-w
https://doi.org/10.1007/s11357-019-00131-w