Výsledky vyhledávání - "Sathya M. Schnell"

Tumor-derived exosomes, microRNAs, and cancer immune suppression

Autor: Michael R. Olin, Sathya M. Schnell, Michael W. Graner

Publikováno v: Seminars in Immunopathology. 40:505-515

Originally considered to be part of a cellular waste pathway, expansive research into exosomes has shown that these vesicles possess a vast array of functional utilities. As vital transporters of materials for communications between cells, particular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fffeadcf79a36d0f75e1955f143da2c
https://doi.org/10.1007/s00281-018-0689-6

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1,2,3-Triazole Rings as a Disulfide Bond Mimetic in Chimeric AGRP-Melanocortin Peptides: Design, Synthesis, and Functional Characterization

Autor: James R. Rocca, Katie T. Freeman, Sathya M. Schnell, Carrie Haskell-Luevano, Srinivasa R. Tala, Anamika Singh, Cody J. Lensing

Publikováno v: ACS Chemical Neuroscience. 9:1001-1013

The melanocortin system is involved in the regulation of complex physiological functions, including energy and weight homeostasis, feeding behavior, inflammation, sexual function, pigmentation, and exocrine gland function. The five melanocortin recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59543bdfa43bbbdc613269c4ad6c348
https://doi.org/10.1021/acschemneuro.7b00422

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A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage

Autor: Danielle N. Adank, Katie T. Freeman, Sathya M. Schnell, Carrie Haskell-Luevano, Cody J. Lensing, Stacey L. Wilber, Adam T. Zarth, Robert C. Speth

Publikováno v: ACS Chemical Neuroscience. 8:1262-1278

Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro; however, studies of their functional in vivo effects have been limited. The current report compares the effects of homobivalent ligand CJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf822f5056ea058ee2e6a891d1302b54
https://doi.org/10.1021/acschemneuro.6b00399

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A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands

Autor: Sathya M. Schnell, Carrie Haskell-Luevano, Mark D. Ericson, Katie T. Freeman

Publikováno v: Journal of Medicinal Chemistry. 60:805-813

The melanocortin system consists of five receptor subtypes, endogenous agonists, and naturally occurring antagonists. These receptors and ligands have been implicated in numerous biological pathways including processes linked to obesity and food inta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc34f4e280d6e7dc73df567bd9d66fc
https://doi.org/10.1021/acs.jmedchem.6b01707

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An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers

Autor: Sathya M. Schnell, Robert C. Speth, Danielle N. Adank, Cody J. Lensing, Katie T. Freeman, Carrie Haskell-Luevano

Publikováno v: Journal of Medicinal Chemistry. 59:3112-3128

Pharmacological probes for the melanocortin receptors have been utilized for studying various disease states including cancer, sexual function disorders, Alzheimer's disease, social disorders, cachexia, and obesity. This study focused on the design a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e8e35bcc45ed4e516bea1fea9e5c64
https://doi.org/10.1021/acs.jmedchem.5b01894

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Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors

Autor: Sathya M. Schnell, Cody J. Lensing, Adam T. Zarth, Carrie Haskell-Luevano, Robert C. Speth, Katie T. Freeman

Publikováno v: Journal of medicinal chemistry. 62(1)

Understanding the functional relevance of G protein-coupled receptor (GPCR) homodimerization has been limited by the insufficient tools to assess asymmetric signaling occurring within dimers comprised of the same receptor type. We present unmatched b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1900b0a3048d84edd5d3aa5e3851ce1c
https://pubmed.ncbi.nlm.nih.gov/29669202

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A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH

Autor: Cody J, Lensing, Danielle N, Adank, Stacey L, Wilber, Katie T, Freeman, Sathya M, Schnell, Robert C, Speth, Adam T, Zarth, Carrie, Haskell-Luevano

Publikováno v: ACS chemical neuroscience. 8(6)

Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro, however studies of their functional in vivo effects have been limited. The current report compares the effects of homobivalent ligand CJL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::088ec26e14e4b0a38b55fa174b5b03b8
https://pubmed.ncbi.nlm.nih.gov/28128928

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