Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sathya D. Unudurthi"'
Publikováno v:
MethodsX, Vol 7, Iss , Pp 100755- (2020)
Image processing and quantification is a routine and important task across disciplines in biomedical research. Understanding the effects of disease on the tissue and organ level often requires the use of images, however the process of interpreting th
Externí odkaz:
https://doaj.org/article/51ba065b1b324cdc9d4ab2c1f770fc6b
Autor:
Przemysław B. Radwański, PharmD, PhD, Hsiang-Ting Ho, PhD, Rengasayee Veeraraghavan, PhD, Lucia Brunello, PhD, Bin Liu, PhD, Andriy E. Belevych, PhD, Sathya D. Unudurthi, PhD, Michael A. Makara, PhD, Silvia G. Priori, MD, PhD, Pompeo Volpe, PhD, Antonis A. Armoundas, PhD, Wolfgang H. Dillmann, MD, Bjorn C. Knollmann, MD, PhD, Peter J. Mohler, PhD, Thomas J. Hund, PhD, Sándor Györke, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 4, Pp 251-266 (2016)
Although triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the sub
Externí odkaz:
https://doaj.org/article/14f969abcf034b40ad9a83088e11255d
Autor:
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 4 (2016)
BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K
Externí odkaz:
https://doaj.org/article/195dd38bac8642e9ae9ebc7258873b75
Autor:
Drew M, Nassal, Nehal J, Patel, Sathya D, Unudurthi, Rebecca, Shaheen, Jane, Yu, Peter J, Mohler, Thomas J, Hund
Publikováno v:
The Journal of Biological Chemistry
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein βIV-spectrin as an important step in CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::489fe6d1e0962abf301fa87dc4345e10
https://pubmed.ncbi.nlm.nih.gov/34153319
https://pubmed.ncbi.nlm.nih.gov/34153319
Publikováno v:
Expert Review of Cardiovascular Therapy. 16:59-65
INTRODUCTION In the heart, pathways that transduce extracellular environmental cues (e.g. mechanical force, inflammatory stress) into electrical and/or chemical signals at the cellular level are critical for the organ-level response to chronic biomec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2130074d8c00c72689486ff451deba
https://doi.org/10.1080/14779072.2018.1418664
https://doi.org/10.1080/14779072.2018.1418664
Autor:
Drew M. Nassal, Peter J. Mohler, Jane Yu, Sathya D. Unudurthi, Thomas J. Hund, Rebecca Shaheen, Nehal J. Patel
Publikováno v:
Journal of Biological Chemistry. 297:100893
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein βIV-spectrin as an important step in CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890dae6527adba4bc2f316cf93d966fe
https://doi.org/10.1016/j.jbc.2021.100893
https://doi.org/10.1016/j.jbc.2021.100893
Autor:
Drew M. Nassal, Curtis G. Pierson, Shyam S. Bansal, Evelyn Thomas, Nehal J. Patel, Peter J. Mohler, Thomas J. Hund, Jane Yu, Sathya D. Unudurthi
Publikováno v:
Life Sci
Aims Heart failure (HF) is characterized by compromised cardiac structure and function. Previous work has identified a link between upregulation of pro-inflammatory cytokines and HF. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99865505b7757083d2a645eb6c117c2c
https://pubmed.ncbi.nlm.nih.gov/32070706
https://pubmed.ncbi.nlm.nih.gov/32070706
Autor:
Benjamin W Scandling, Drew M. Nassal, Sathya D. Unudurthi, Daniel Gratz, Xianyao Xu, Federica Accornero, Thomas J. Hund, Keith J. Gooch, Peter J. Mohler, Amara Greer-Short, Anuradha Kalyanasundaram, Vadim V. Fedorov, Nehal J. Patel
Publikováno v:
JCI Insight. 4
Increased fibrosis is a characteristic remodeling response to biomechanical and neurohumoral stress and a determinant of cardiac mechanical and electrical dysfunction in disease. Stress-induced activation of cardiac fibroblasts (CFs) is a critical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5223a42f2ff8021ccc70ec3d0e41b7f3
https://doi.org/10.1172/jci.insight.131046
https://doi.org/10.1172/jci.insight.131046
Autor:
Benjamin W Scandling, Nehal J. Patel, Drew M. Nassal, Amara Greer-Short, Thomas J. Hund, Sathya D. Unudurthi, Xianyao Xu, Keith J. Gooch, Peter J. Mohler
Publikováno v:
Circulation Research. 125
Increased fibrosis is associated with cardiac dysfunction and arrhythmias. Activation of quiescent cardiac fibroblasts (CFs) occurs in response to injury although the underlying mechanistic pathways remain unclear. The cytoskeletal protein β IV -spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c186aa07d7ec693fbca29aa6d453b7
https://doi.org/10.1161/res.125.suppl_1.844
https://doi.org/10.1161/res.125.suppl_1.844
Autor:
Amara Greer-Short, Cemantha Lane, Ning Li, Michel Skaf, Julia O. Reynolds, Thomas J. Hund, Xander H.T. Wehrens, Daniel Gratz, Katherina M. Alsina, Hassan Musa, Sathya D. Unudurthi, Li Ni, Peter J. Mohler, Tarah A. Word, Mona El-Refaey, Vadim V. Fedorov
Publikováno v:
Heart Rhythm
Background Atrial fibrillation (AF) is the most common type of arrhythmia. Abnormal atrial myocyte Ca2+ handling promotes aberrant membrane excitability and remodeling that are important for atrial arrhythmogenesis. The sequence of molecular events l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0befe6e6e7f30491b5291e3d0dd8c8d
https://pubmed.ncbi.nlm.nih.gov/31622781
https://pubmed.ncbi.nlm.nih.gov/31622781