Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sathya D, Unudurthi"'
Publikováno v:
MethodsX, Vol 7, Iss , Pp 100755- (2020)
Image processing and quantification is a routine and important task across disciplines in biomedical research. Understanding the effects of disease on the tissue and organ level often requires the use of images, however the process of interpreting th
Externí odkaz:
https://doaj.org/article/51ba065b1b324cdc9d4ab2c1f770fc6b
Autor:
Przemysław B. Radwański, PharmD, PhD, Hsiang-Ting Ho, PhD, Rengasayee Veeraraghavan, PhD, Lucia Brunello, PhD, Bin Liu, PhD, Andriy E. Belevych, PhD, Sathya D. Unudurthi, PhD, Michael A. Makara, PhD, Silvia G. Priori, MD, PhD, Pompeo Volpe, PhD, Antonis A. Armoundas, PhD, Wolfgang H. Dillmann, MD, Bjorn C. Knollmann, MD, PhD, Peter J. Mohler, PhD, Thomas J. Hund, PhD, Sándor Györke, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 4, Pp 251-266 (2016)
Although triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the sub
Externí odkaz:
https://doaj.org/article/14f969abcf034b40ad9a83088e11255d
Autor:
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 4 (2016)
BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K
Externí odkaz:
https://doaj.org/article/195dd38bac8642e9ae9ebc7258873b75
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Normal heart rhythm (sinus rhythm) depends on regular activity of the sinoatrial node (SAN), a heterogeneous collection of specialized myocytes in the right atrium. SAN cells, in general, possess a unique electrophysiological profile that promotes sp
Externí odkaz:
https://doaj.org/article/e39507284eef4eccbc5506963bab7be2
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Post-translational modification of membrane proteins (e.g. ion channels, receptors) by protein kinases is an essential mechanism for control of excitable cell function. Importantly, loss of temporal and/or spatial control of ion channel post-translat
Externí odkaz:
https://doaj.org/article/a74a88d2684e40e78b13e13a6a48eb3e
Autor:
Drew M, Nassal, Nehal J, Patel, Sathya D, Unudurthi, Rebecca, Shaheen, Jane, Yu, Peter J, Mohler, Thomas J, Hund
Publikováno v:
The Journal of Biological Chemistry
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein βIV-spectrin as an important step in CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::489fe6d1e0962abf301fa87dc4345e10
https://pubmed.ncbi.nlm.nih.gov/34153319
https://pubmed.ncbi.nlm.nih.gov/34153319
Autor:
Drew M. Nassal, Peter J. Mohler, Jane Yu, Sathya D. Unudurthi, Thomas J. Hund, Rebecca Shaheen, Nehal J. Patel
Publikováno v:
Journal of Biological Chemistry. 297:100893
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein βIV-spectrin as an important step in CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890dae6527adba4bc2f316cf93d966fe
https://doi.org/10.1016/j.jbc.2021.100893
https://doi.org/10.1016/j.jbc.2021.100893
Publikováno v:
Expert Review of Cardiovascular Therapy. 16:59-65
INTRODUCTION In the heart, pathways that transduce extracellular environmental cues (e.g. mechanical force, inflammatory stress) into electrical and/or chemical signals at the cellular level are critical for the organ-level response to chronic biomec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2130074d8c00c72689486ff451deba
https://doi.org/10.1080/14779072.2018.1418664
https://doi.org/10.1080/14779072.2018.1418664
Autor:
Drew M. Nassal, Curtis G. Pierson, Shyam S. Bansal, Evelyn Thomas, Nehal J. Patel, Peter J. Mohler, Thomas J. Hund, Jane Yu, Sathya D. Unudurthi
Publikováno v:
Life Sci
Aims Heart failure (HF) is characterized by compromised cardiac structure and function. Previous work has identified a link between upregulation of pro-inflammatory cytokines and HF. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99865505b7757083d2a645eb6c117c2c
https://pubmed.ncbi.nlm.nih.gov/32070706
https://pubmed.ncbi.nlm.nih.gov/32070706
Autor:
Benjamin W Scandling, Drew M. Nassal, Sathya D. Unudurthi, Daniel Gratz, Xianyao Xu, Federica Accornero, Thomas J. Hund, Keith J. Gooch, Peter J. Mohler, Amara Greer-Short, Anuradha Kalyanasundaram, Vadim V. Fedorov, Nehal J. Patel
Publikováno v:
JCI Insight. 4
Increased fibrosis is a characteristic remodeling response to biomechanical and neurohumoral stress and a determinant of cardiac mechanical and electrical dysfunction in disease. Stress-induced activation of cardiac fibroblasts (CFs) is a critical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5223a42f2ff8021ccc70ec3d0e41b7f3
https://doi.org/10.1172/jci.insight.131046
https://doi.org/10.1172/jci.insight.131046