Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sathivel Ponniah"'
Autor:
Guang, Li, Juejin, Wang, Ping, Liao, Peter, Bartels, Hengyu, Zhang, Dejie, Yu, Mui Cheng, Liang, Kian Keong, Poh, Chye Yun, Yu, Fengli, Jiang, Tan Fong, Yong, Yuk Peng, Wong, Zhenyu, Hu, Hua, Huang, Guangqin, Zhang, Mary Joyce, Galupo, Jin-Song, Bian, Sathivel, Ponniah, Scott Lee, Trasti, Kelvin, See, Roger, Foo, Uta C, Hoppe, Stefan, Herzig, Tuck Wah, Soong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(21)
To directly address in vivo significance of the altered CaV1.2 channel property arising from alternative splicing, we generated CaV1.2 exon 33-specific knockout (exon 33−/−) mice. Here, we showed that the exclusion of alternative exon 33 altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fde7935dc7896b1aa58e14dc2f27262
https://pubmed.ncbi.nlm.nih.gov/28490495
https://pubmed.ncbi.nlm.nih.gov/28490495
Autor:
Yuk Peng Wong, Jin-Song Bian, Mary Joyce Galupo, Sathivel Ponniah, Juejin Wang, Chye Yun Yu, Peter Bartels, Uta C. Hoppe, Guang Li, Dejie Yu, Stefan Herzig, Fengli Jiang, Mui Cheng Liang, Ping Liao, Hua Huang, Guangqin Zhang, Kelvin See, Kian Keong Poh, Hengyu Zhang, Scott L. Trasti, Roger Foo, Tuck Wah Soong, Zhenyu Hu, Tan Fong Yong
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Alternative splicing changes the CaV1.2 calcium channel electrophysiological property, but the in vivo significance of such altered channel function is lacking. Structure-function studies of heterologously expressed CaV1.2 channels could not recapitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e6f1a9511930b1886a4d6771419e5a
https://doi.org/10.1073/pnas.1617205114
https://doi.org/10.1073/pnas.1617205114
Autor:
Yasuo Takeda, Shi-Qiang Wang, Kazutada Watanabe, Melitta Schachner, Yen Ling Jessie Tan, Catherine J. Pallen, Haihong Ye, Zhi-Cheng Xiao, Sathivel Ponniah
Publikováno v:
The EMBO Journal. 27:188-200
Apical dendrites of pyramidal neurons in the neocortex have a stereotypic orientation that is important for neuronal function. Neural recognition molecule Close Homolog of L1 (CHL1) has been shown to regulate oriented growth of apical dendrites in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b080288531460897a87d456929e44aad
https://doi.org/10.1038/sj.emboj.7601939
https://doi.org/10.1038/sj.emboj.7601939
Autor:
Nai-dy Wang, Shing Chuan Hooi, Esther Wong, Sathivel Ponniah, Ee Hong Tan, Mirtha Laban, Aileen Wee
Publikováno v:
Cancer Research. 65:10330-10337
Hypoxia-inducible factor 1 (HIF-1) is the central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for solid tumor therapy. Inhibition of HIF-1 is expected to result in the attenuation of hypoxia-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d3f2325b8a28f1ac6d1ea99077fa0d
https://doi.org/10.1158/0008-5472.can-04-4486
https://doi.org/10.1158/0008-5472.can-04-4486
Publikováno v:
Biochemical and Biophysical Research Communications. 314:321-329
Studies in cultured cells have implicated protein tyrosine phosphatase alpha (PTPalpha) as a potential regulator of insulin signaling. The physiological role of PTPalpha in insulin action was investigated using gene-targeted mice deficient in PTPalph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecc988ea97a7f4931711eb0dbff91a3
https://doi.org/10.1016/j.bbrc.2003.12.087
https://doi.org/10.1016/j.bbrc.2003.12.087
Autor:
Sathivel Ponniah, Wanjin Hong, Zhihong Zhou, Shen Yon Toh, Chee Peng Ng, Ke Guo, Sheng-Cai Lin, Peng Li, Zhengming Chen
Publikováno v:
Nature Genetics. 35:49-56
The thermogenic activity of brown adipose tissue (BAT), important for adaptive thermogenesis and energy expenditure, is mediated by the mitochondrial uncoupling protein1 (Ucp1) that uncouples ATP generation and dissipates the energy as heat. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb684b8e49615a0ccb96d49bdca82105
https://doi.org/10.1038/ng1225
https://doi.org/10.1038/ng1225
Autor:
Dennis Z.-M. Wang, Sathivel Ponniah, Catherine J. Pallen, Raymond M.H. Teng, Xiaoning Si, Kenneth F. Ryan, Li Zeng, Kwok Peng Ng, Wei-Ping Yu, Hoa Thi Le
Publikováno v:
The Journal of Cell Biology
We investigated the molecular and cellular actions of receptor protein tyrosine phosphatase (PTP) alpha in integrin signaling using immortalized fibroblasts derived from wild-type and PTP alpha-deficient mouse embryos. Defects in PTP alpha-/- migrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687159c74d346a6b39d9bdf740466b6e
https://doi.org/10.1083/jcb.200206049
https://doi.org/10.1083/jcb.200206049
Autor:
Byrappa Venkatesh, Sydney Brenner, Sathivel Ponniah, Yue Wang, Wai Ho Yap, Alice Tay, Y. H. Tan, Chih-Fong Chou
Publikováno v:
Proceedings of the National Academy of Sciences. 99:2936-2941
Thelckgene encodes a lymphocyte-specific protein-tyrosine kinase that is implicated in T cell maturation and signaling. In mammals, the transcription of thelckgene is regulated by two independent promoters, the proximal promoter, which is active in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f396b43d7caf46517c9c84fa54f7647
https://doi.org/10.1073/pnas.032680599
https://doi.org/10.1073/pnas.032680599
Publikováno v:
Molecular and Cellular Biochemistry. 146:13-21
Phospholamban (PLB) is a regulator of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) expressed in cardiac, slow-twitch skeletal, and smooth muscles. Phospholamban is not expressed in the sarcoplasmic reticulum of fast-twitch skeletal muscle, but i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310a9e72ab45b9dc7eb1928ef0f4874b
https://doi.org/10.1007/bf00926876
https://doi.org/10.1007/bf00926876
Autor:
John J. Duffy, Ingrid L. Grupp, Judy M. Harrer, Thomas Doetschman, Wusheng Luo, Sathivel Ponniah, Gunter Grupp, Evangelia G. Kranias
Publikováno v:
Circulation Research. 75:401-409
Phospholamban is the regulator of the Ca(2+)-ATPase in cardiac sarcoplasmic reticulum (SR), and it has been suggested to be an important determinant in the inotropic responses of the heart to beta-adrenergic stimulation. To determine the role of phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5d09bf09b8b346b54228496eba4ba4
https://doi.org/10.1161/01.res.75.3.401
https://doi.org/10.1161/01.res.75.3.401