Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics.

Autor: Lai PK; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, New Jersey, USA., Gallegos A; Dosage Form Design and Development, AstraZeneca, Gaithersburg, Maryland, USA., Mody N; Dosage Form Design and Development, AstraZeneca, Gaithersburg, Maryland, USA., Sathish HA; Dosage Form Design and Development, AstraZeneca, Gaithersburg, Maryland, USA., Trout BL; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Publikováno v: MAbs [MAbs] 2022 Jan-Dec; Vol. 14 (1), pp. 2026208.

Identifying Key Residues That Drive Strong Electrostatic Attractions between Therapeutic Antibodies.

Autor: Ferreira GM; Department of Chemical and Biomolecular Engineering , University of Delaware , Newark , Delaware 19716 , United States., Shahfar H; Department of Chemical and Biomolecular Engineering , University of Delaware , Newark , Delaware 19716 , United States.; Department of Physics and Astronomy , University of Delaware , Newark , Delaware 19716 , United States., Sathish HA; AstraZeneca , Gaithersburg , Maryland 20878 , United States., Remmele RL Jr; RemSciBiothera, Inc. , Camarillo , California 93012 , United States., Roberts CJ; Department of Chemical and Biomolecular Engineering , University of Delaware , Newark , Delaware 19716 , United States.

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2019 Dec 19; Vol. 123 (50), pp. 10642-10653. Date of Electronic Publication: 2019 Dec 09.

Understanding the Role of Preferential Exclusion of Sugars and Polyols from Native State IgG1 Monoclonal Antibodies and its Effect on Aggregation and Reversible Self-Association.

Autor: Sudrik CM; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Room 66-350, Cambridge, MA, 02139, USA., Cloutier T; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Room 66-350, Cambridge, MA, 02139, USA., Mody N; Formulation Sciences, MedImmune LLC, Gaithersburg, MD, 20878, USA., Sathish HA; Formulation Sciences, MedImmune LLC, Gaithersburg, MD, 20878, USA., Trout BL; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Room 66-350, Cambridge, MA, 02139, USA. trout@mit.edu.

Publikováno v: Pharmaceutical research [Pharm Res] 2019 May 24; Vol. 36 (8), pp. 109. Date of Electronic Publication: 2019 May 24.

Stability of Protein Pharmaceuticals: Recent Advances.

Autor: Manning MC; Legacy BioDesign LLC, Johnstown, CO, USA. manning@legacybiodesign.com.; Department of Chemistry, Colorado State University, Fort Collins, CO, USA. manning@legacybiodesign.com., Holcomb RE; Legacy BioDesign LLC, Johnstown, CO, USA.; Department of Chemistry, Colorado State University, Fort Collins, CO, USA., Payne RW; Legacy BioDesign LLC, Johnstown, CO, USA.; Department of Chemistry, Colorado State University, Fort Collins, CO, USA., Stillahn JM; Legacy BioDesign LLC, Johnstown, CO, USA.; Department of Chemistry, Colorado State University, Fort Collins, CO, USA., Connolly BD; Spyre Therapeutics, Inc., Waltham, MA, USA., Katayama DS; Samsung Biologics, 201-2, Songdo-Dong, Yeonsu-Gu, Incheon, Korea., Liu H; Scholar Rock, Inc., Cambridge, MA, USA., Matsuura JE; Jim Matsuura Pharma Consulting LLC, Lafayette, CO, USA., Murphy BM; Just-Evotec, Seattle, WA, USA., Henry CS; Department of Chemistry, Colorado State University, Fort Collins, CO, USA., Crommelin DJA; Utrecht University, Utrecht, Netherlands.

Publikováno v: Pharmaceutical research [Pharm Res] 2024 Jul; Vol. 41 (7), pp. 1301-1367. Date of Electronic Publication: 2024 Jun 27.

A bioengineered anti-VEGF protein with high affinity and high concentration for intravitreal treatment of wet age-related macular degeneration.

Autor: Chengnan Huang¹, Yuelin Wang^2,3, Jinliang Huang⁴, Huiqin Liu⁴, Zhidong Chen¹, Yang Jiang^2,3 jiangyangpumch@126.com, Youxin Chen^2,3 chenyx@pumch.cn, Feng Qian¹ qianfeng@tsinghua.edu.cn

Publikováno v: Bioengineering & Translational Medicine. Mar2024, Vol. 9 Issue 2, p1-11. 11p.