Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Satheesh Kesavan Nair"'
Autor:
Joel C. Barrish, John Hynes, Ajay Saxena, Natesan Murugesan, Dianlin Xie, Anjaneya Chimalakonda, Stefan Ruepp, Mitalee Das, Richard Rampulla, Durgarao Kantheti, Chunhong Yan, Julie Carman, Jignesh Nagar, Siva Subramani, Qian Ruan, William J. Pitts, Rajeev S. Bhide, Paul A. Elzinga, Venkatram Reddy Paidi, John S. Sack, Mark Fereshteh, Thangavel Soodamani, Amrita Jha Mukherjee, T. Thanga Mariappan, Ramesh Kumar Sistla, Kaushik Ghosh, Debarati Mazumder, Kamalavenkatesh Palanisamy, Deborah A. Holloway, Susan E. Kiefer, John A. Newitt, Satheesh Kesavan Nair, Polimera Subba Rao, Shailesh Dudhgoankar, Percy H. Carter, Xin Li, Srinivas Maddi, S. Pon Saravanakumar, Sreekantha Ratna Kumar, Sucharita Bose
Publikováno v:
ACS Med Chem Lett
[Image: see text] IRAK4 is an attractive therapeutic target for the treatment of inflammatory conditions. Structure guided optimization of a nicotinamide series of inhibitors has been expanded to explore the IRAK4 front pocket. This has resulted in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bbdf7e3f4256a866250ac0c4fba45e
https://doi.org/10.1021/acsmedchemlett.0c00082
https://doi.org/10.1021/acsmedchemlett.0c00082
Autor:
Lokesh Babu Jarugu, Suresh Krishnamoorthy, Anuradha Gupta, Muniyappa Shankar, Prakasam Kuppusamy, Satheesh Kesavan Nair, Joseph B. Santella, Muthalagu Vetrichelvan, Pirama Nayagam Arunachalam, Roshan Y. Nimje, Sridhar Vanteru, Arvind Mathur, Percy H. Carter, China Anki Reddy, Prakash Anjanappa, Nanjundaswamy Kanikahalli Chikkananjaiah, Sivakumar Ganesan, Richard Rampulla, Arun Kumar Gupta, Nageswararao Maddala, Murali Botlagunta, John Hynes
Publikováno v:
Organic Process Research & Development. 23:912-918
A scalable route to 1-(5-(4-(3-hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (1, BMS-986236) was developed by incorporating an alternate azide intermediate following safety-dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::843761fabf25ac8486d70689975be26a
https://doi.org/10.1021/acs.oprd.9b00023
https://doi.org/10.1021/acs.oprd.9b00023
Autor:
T. Thanga Mariappan, Durga Shiv Prasad, Siva Subramani, Jun Zhu, Ajay Saxena, Wen-Pin Yang, Prasad Krishnamurthy, Julie Carman, Satheesh Kesavan Nair, Dawn K. Stetsko, Kim W. McIntyre, John V. Duncia, Joseph B. Santella, Kamala Venkatesh, Ratika Srivastava, Jignesh Nagar, Shailesh Dudhgaonkar, John Hynes, Sabariya Selvam, Li Fan, Sourabh Ranade, Stefan Ruepp, Xin Li, Deborah A. Holloway, Preethi Karunanithi
Publikováno v:
The Journal of Immunology. 198:1308-1319
The serine/threonine kinase IL-1R–associated kinase (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that demonstrates equipotent activity against multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a8653b51837126331d5cfca323e6ad
https://doi.org/10.4049/jimmunol.1600583
https://doi.org/10.4049/jimmunol.1600583