Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Satadru K. Lahiri"'
Autor:
Jia Song, Jose Alberto Navarro-Garcia, Jiao Wu, Arnela Saljic, Issam Abu-Taha, Luge Li, Satadru K. Lahiri, Joshua A. Keefe, Yuriana Aguilar-Sanchez, Oliver M. Moore, Yue Yuan, Xiaolei Wang, Markus Kamler, William E. Mitch, Gema Ruiz-Hurtado, Zhaoyong Hu, Sandhya S. Thomas, Dobromir Dobrev, Xander H.T. Wehrens, Na Li
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Chronic kidney disease (CKD) is associated with a higher risk of atrial fibrillation (AF). The mechanistic link between CKD and AF remains elusive. IL-1β, a main effector of NLR family pyrin domain–containing 3 (NLRP3) inflammasome activation, is
Externí odkaz:
https://doaj.org/article/7058a42f3d504f2f9a85c2061605f1cd
Publikováno v:
Expert Opin Ther Targets
INTRODUCTION: Abnormal calcium signaling between organelles such as the sarcoplasmic reticulum (SR), mitochondria and lysosomes is a key feature of various heart diseases. Calcium serves as a secondary messenger mediating inter-organellar crosstalk,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d739f75bcc177c3da2ceaaf07a4ef8ff
https://doi.org/10.1080/14728222.2022.2067479
https://doi.org/10.1080/14728222.2022.2067479
Autor:
Sasha Z. Prisco, Lynn M. Hartweck, Felipe Kazmirczak, Jenna B. Mendelson, Stephanie L. Deng, Satadru K. Lahiri, Xander H.T. Wehrens, Kurt W. Prins
Publikováno v:
bioRxiv
Right ventricular dysfunction (RVD) is a risk factor for mortality in multiple cardiovascular diseases, but approaches to combat RVD are lacking. Therapies used for left heart failure are largely ineffective in RVD, and thus the identification of mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fdb6f1d06eaa74c86cb1bd94208401
https://doi.org/10.1101/2023.02.07.527576
https://doi.org/10.1101/2023.02.07.527576
Autor:
Sasha Z Prisco, Megan Eklund, Lynn Hartweck, Ann QUICK, Satadru K Lahiri, Xander H Wehrens, Kurt W Prins
Publikováno v:
Circulation. 144
Introduction: Junctophilin-2 (JPH2) plays a crucial role in t-tubule structure/function and gene regulation in cardiomyocytes. In addition, JPH2 downregulation causes mitochondrial dysfunction and mitofusin-2 (MFN2) dysregulation, but the link betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d597b0a4d99b889eccd6e6d83f169fb8
https://doi.org/10.1161/circ.144.suppl_1.10338
https://doi.org/10.1161/circ.144.suppl_1.10338
Autor:
Na Li, Dobromir Dobrev, Satadru K. Lahiri, Haihao Wang, Xander H.T. Wehrens, Li Ni, Frank U. Müller, Hannah M. Campbell, Xiang Wei, Jiali Nie, Julia O. Reynolds, Xiaolu Pan, Issam Abu-Taha, Wilhelm Schmitz, Dao Wen Wang, Markus Kamler
Publikováno v:
Cardiovasc Res
Aims Abnormal intracellular calcium handling contributes to the progressive nature of atrial fibrillation (AF), the most common sustained cardiac arrhythmia. Evidence in mouse models suggests that activation of the nuclear factor of activated T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b787a9d28967973a96e7d9a4e37bc4d2
https://europepmc.org/articles/PMC9586567/
https://europepmc.org/articles/PMC9586567/
Publikováno v:
J Clin Invest
The cardiac conduction system (CCS) ensures regular contractile function, and injury to any of its components can cause cardiac dysrhythmia. Although all cardiomyocytes (CMs) originate from common progenitors, the CCS is composed of biologically dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0ff2e1491d32e7a22787a171e4e43e
https://europepmc.org/articles/PMC8483745/
https://europepmc.org/articles/PMC8483745/
Publikováno v:
Am J Transl Res
Post-therapeutic relapse remains the biggest challenge to breast cancer management. The re-initiation of proliferation of dormant tumor cells in either metastatic or primary tumor location marks the final rate-limiting step of malignancy and mortalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1981c4f22a5b4cd6abb8ba6622e801ae
https://pubmed.ncbi.nlm.nih.gov/35273724
https://pubmed.ncbi.nlm.nih.gov/35273724
Publikováno v:
Pflugers Arch
Cardiomyocyte contraction relies on precisely regulated intracellular Ca(2+) signaling through various Ca(2+) channels and transporters. In this article, we will review the physiological regulation of Ca(2+) handling and its role in maintaining norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe47dd6315a6912c6fc117daf50d58e
https://europepmc.org/articles/PMC10070045/
https://europepmc.org/articles/PMC10070045/
Autor:
Oliver Moore, Issam Abu-Taha, Lucia Moreira, Mohit Hulsurkar, Xander H.T. Wehrens, Dobromir Dobrev, Markus Kamler, Stanley Nattel, Svetlana Reilly, Satadru K. Lahiri
Publikováno v:
Circulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539b9eadf366aac97dbb52622802fd81
https://www.ncbi.nlm.nih.gov/pubmed/34516304
https://www.ncbi.nlm.nih.gov/pubmed/34516304
Autor:
Shoumo Bhattacharya, George Krasopoulos, Abhijit Takawale, Adam J. Mead, Patrice Naud, Manuel Mayr, Keith M. Channon, Stanley Nattel, Rana Sayeed, Angela Lee, Constantinos Psarros, David A. Menassa, Charles Redwood, Neil Evans, Michele V Clarke, Martin Sirois, Jean-Claude Tardif, Satadru K. Lahiri, Javier Barallobre-Barreiro, Svetlana Reilly, Agne Antanaviciute, Barbara Casadei, Alexander J Sparrow, Neil Ashley, Rachel A Davey, Neelam Mehta, Lucia Moreira, Patricia K Russell, Mohit Hulsurkar, Konstantinos Theofilatos, Paul Robinson, Jeffrey D Zajac, Marc Antoine Gillis, Mary Norris, Alison Simmons, Xander H.T. Wehrens
Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly to the risk of stroke in humans1. Atrial-tissue fibrosis is a central pathophysiological feature of atrial fibrillation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9999cd8190f6e07716216a1cedd93bf
https://eprints.soton.ac.uk/444792/
https://eprints.soton.ac.uk/444792/