Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Saswati N Chand"'
Autor:
Matthew J Schiewer, Amy C Mandigo, Nicolas Gordon, Fangjin Huang, Sanchaika Gaur, Renée de Leeuw, Shuang G Zhao, Joseph Evans, Sumin Han, Theodore Parsons, Ruth Birbe, Peter McCue, Christopher McNair, Saswati N Chand, Ylenia Cendon‐Florez, Peter Gallagher, Jennifer J McCann, Neermala Poudel Neupane, Ayesha A Shafi, Emanuela Dylgjeri, Lucas J Brand, Tapio Visakorpi, Ganesh V Raj, Costas D Lallas, Edouard J Trabulsi, Leonard G Gomella, Adam P Dicker, Wm. Kevin Kelly, Benjamin E Leiby, Beatrice Knudsen, Felix Y Feng, Karen E Knudsen
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp 1-20 (2018)
Abstract PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of P
Externí odkaz:
https://doaj.org/article/044d966fd25b4793a1abaa4247be3583
Autor:
Jonathan R. Brody, Mark L. Tykocinski, Rajanikanth Vadigepalli, Charles J. Yeo, Nicole Meisner-Kober, Jonathan N. Sachs, Janet A. Sawicki, Jordan M. Winter, Angie D. Lobo, Saswati N. Chand, Danielle DeCicco, Mahsa Zarei, Matthew C. Weber, Carmella Romeo
Supplemental Figure Images
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0eb329b7ad88b1e22c594b46622ee1
https://doi.org/10.1158/1541-7786.22511716
https://doi.org/10.1158/1541-7786.22511716
Autor:
Jonathan R. Brody, Mark L. Tykocinski, Rajanikanth Vadigepalli, Charles J. Yeo, Nicole Meisner-Kober, Jonathan N. Sachs, Janet A. Sawicki, Jordan M. Winter, Angie D. Lobo, Saswati N. Chand, Danielle DeCicco, Mahsa Zarei, Matthew C. Weber, Carmella Romeo
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers, in part, due to resistance to both conventional and targeted therapeutics. TRAIL directly induces apoptosis through engagement of cell surface Death Receptors (DR4 and DR5), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34413c451ad46f9bdc5d759366dc3e0d
https://doi.org/10.1158/1541-7786.c.6540022.v1
https://doi.org/10.1158/1541-7786.c.6540022.v1
Autor:
Johann S. de Bono, Neil Pegg, Karen E. Knudsen, Matthew J. Schiewer, David Taddei, Amanda Swain, Jian Ning, Antje J. Neeb, Suzanne Carreira, Nina Tunariu, Rita Pereira, Ana Ferreira, Mateus Crespo, Susana Miranda, Veronica S. Gil, Gareth W. Harbottle, Don Smyth, Richard Brown, Silvia Paoletta, Jonathan Shannon, Stuart Onions, Jenny Worthington, Stuart Thomson, Jordan Lane, Amy Prosser, Meera Raja, Barbara Young, William West, Denisa Bogdan, Jan Rekowski, Bora Gurel, Ruth Riisnaes, Ines Figueiredo, Abhijit Pal, Saswati N. Chand, Christopher McNair, Wei Yuan, Nigel Brooks, Adam Sharp, Jonathan Welti
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d313da933b889d09a6fcaf5a2385ff7
https://doi.org/10.1158/2159-8290.22540441.v1
https://doi.org/10.1158/2159-8290.22540441.v1
Autor:
Jonathan R. Brody, Dan A. Dixon, Jordan M. Winter, Paul M. Campbell, Charles J. Yeo, Avinoam Nevler, Cinthya Y. Lowder, Austin Goetz, Eric Londin, Matthew C. Stout, Carmella Romeo, Nicole C. Mambelli-Lisboa, Saswati N. Chand, Ranjan Preet, Mahsa Zarei, Edwin C. Cheung, Shruti Lal
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer. The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893d87f75b99f780caa6bbbab5107d71
https://doi.org/10.1158/1541-7786.c.6540345
https://doi.org/10.1158/1541-7786.c.6540345
Autor:
Jonathan R. Brody, Mark L. Tykocinski, Rajanikanth Vadigepalli, Charles J. Yeo, Nicole Meisner-Kober, Jonathan N. Sachs, Janet A. Sawicki, Jordan M. Winter, Angie D. Lobo, Saswati N. Chand, Danielle DeCicco, Mahsa Zarei, Matthew C. Weber, Carmella Romeo
Supplemental Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd335ede44214512d502d655f8c375f
https://doi.org/10.1158/1541-7786.22511713
https://doi.org/10.1158/1541-7786.22511713
Autor:
Jonathan R. Brody, Allan M. Jordan, Dominic I. James, Donald Ogilvie, Michael J. Pishvaian, Talia Golan, Kenneth P. Olive, Jordan M. Winter, Charles J. Yeo, Dikla Atias, Yulia Glick Gorman, Chani Stossel, Maria Raitses-Gurevich, Ian D. Waddell, Kate M. Smith, Cinthya Yabar Lowder, Christopher W. Schultz, Joseph Cozzitorto, Avinoam Nevler, AnnJosette Ramirez, Saswati N. Chand, Grace A. McCarthy, Lebaron C. Agostini, Aditi Jain
Supplementary Fig S7 describes western blot and RTPCR of PARG in modified shPARG cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12baac012d9c7c055a7134059d275323
https://doi.org/10.1158/0008-5472.22421175
https://doi.org/10.1158/0008-5472.22421175
Autor:
Jonathan R. Brody, Allan M. Jordan, Dominic I. James, Donald Ogilvie, Michael J. Pishvaian, Talia Golan, Kenneth P. Olive, Jordan M. Winter, Charles J. Yeo, Dikla Atias, Yulia Glick Gorman, Chani Stossel, Maria Raitses-Gurevich, Ian D. Waddell, Kate M. Smith, Cinthya Yabar Lowder, Christopher W. Schultz, Joseph Cozzitorto, Avinoam Nevler, AnnJosette Ramirez, Saswati N. Chand, Grace A. McCarthy, Lebaron C. Agostini, Aditi Jain
Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have an average survival of less than 1 year, underscoring the importance of evaluating novel targets with matched targeted agents. We recently identified that poly (ADP) ribose glycohy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2caad1a0117fff7a23cc205bcb261f20
https://doi.org/10.1158/0008-5472.c.6510855.v1
https://doi.org/10.1158/0008-5472.c.6510855.v1
Autor:
Jordan M. Winter, Jonathan R. Brody, Christian M. Metallo, Erin L. Seifert, Eric R. Londin, Charles J. Yeo, Wei Jiang, Joseph A. Cozzitorto, Masaya Jimbo, Saswati N. Chand, Fernando F. Blanco, Cynthia Moffat, Nicole C. Mambelli-Lisboa, Katerina Dukleska, Ali Vaziri-Gohar, Avinoam Nevler, Seth J. Parker, Shruti Lal, Mahsa Zarei
Table S5: Results of RNA sequencing in PDA cell lines (HS-766T and MiaPaCa2) with each modulated by CRISPR/Cas9 to delete HuR expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407575c68ba038659eca4790c467ac6a
https://doi.org/10.1158/0008-5472.22414922
https://doi.org/10.1158/0008-5472.22414922
Autor:
Jordan M. Winter, Jonathan R. Brody, Christian M. Metallo, Erin L. Seifert, Eric R. Londin, Charles J. Yeo, Wei Jiang, Joseph A. Cozzitorto, Masaya Jimbo, Saswati N. Chand, Fernando F. Blanco, Cynthia Moffat, Nicole C. Mambelli-Lisboa, Katerina Dukleska, Ali Vaziri-Gohar, Avinoam Nevler, Seth J. Parker, Shruti Lal, Mahsa Zarei
Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Glucose or glutamine withdr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fca4173cfff5730bbe12fdcc153e4f7
https://doi.org/10.1158/0008-5472.c.6509120.v1
https://doi.org/10.1158/0008-5472.c.6509120.v1