Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Saswati Chatterjee"'
Autor:
Swati Bijlani, Ka Ming Pang, Lakshmi V. Bugga, Sampath Rangasamy, Vinodh Narayanan, Saswati Chatterjee
Publikováno v:
Frontiers in Genome Editing, Vol 6 (2024)
Rett syndrome is an acquired progressive neurodevelopmental disorder caused by de novo mutations in the X-linked MECP2 gene which encodes a pleiotropic protein that functions as a global transcriptional regulator and a chromatin modifier. Rett syndro
Externí odkaz:
https://doaj.org/article/931dac756e3a44ec9e96db46e50e069b
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2022)
The replication-defective, non-pathogenic, nearly ubiquitous single-stranded adeno-associated viruses (AAVs) have gained importance since their discovery about 50 years ago. Their unique life cycle and virus-cell interactions have led to the developm
Externí odkaz:
https://doaj.org/article/e1cab86508544d58813ceb7a3ea96ead
Publikováno v:
Hum Gene Ther
Adeno-associated virus (AAV)-based vectors have transformed into powerful elements of genetic medicine with proven therapeutic efficacy and a good safety profile. Over the years, efforts to transduce hematopoietic stem cells (HSCs) with AAV2 vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280dba4026ea5300046a7faa206abd87
https://doi.org/10.1089/hum.2020.049
https://doi.org/10.1089/hum.2020.049
Autor:
Saswati Chatterjee
Publikováno v:
Lecture Notes in Electrical Engineering ISBN: 9789813344884
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c59ba3b7c57bad936b36b51ea6db9eac
https://doi.org/10.1007/978-981-33-4489-1_13
https://doi.org/10.1007/978-981-33-4489-1_13
Autor:
Saswati Chatterjee
Publikováno v:
Medical Virology: From Pathogenesis to Disease Control ISBN: 9789811573163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a9fce8dadd554e894520e0297d45a5
https://doi.org/10.1007/978-981-15-7317-0_22
https://doi.org/10.1007/978-981-15-7317-0_22
Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing
Autor:
Laura J. Smith, Jason Wright, Gabriella Clark, Taihra Ul-Hasan, Xiangyang Jin, Abigail Fong, Manasa Chandra, Thia St Martin, Hillard Rubin, David Knowlton, Jeff L. Ellsworth, Yuman Fong, Kamehameha K. Wong, Saswati Chatterjee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(31)
The precise correction of genetic mutations at the nucleotide level is an attractive permanent therapeutic strategy for human disease. However, despite significant progress, challenges to efficient and accurate genome editing persist. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fbc8ccc62b56f807738b53d249157c
https://pubmed.ncbi.nlm.nih.gov/30584108
https://pubmed.ncbi.nlm.nih.gov/30584108
Autor:
Laura J Smith, Taihra Ul-Hasan, Sarah K Carvaines, Kim Van Vliet, Ethel Yang, Kamehameha K Wong, Mavis Agbandje-McKenna, Saswati Chatterjee
Publikováno v:
Molecular Therapy. 22(9):1625-1634
Adeno-associated virus (AAV) vectors are proving to be remarkably successful for in vivo gene delivery. Based upon reports of abundant AAV in the human marrow, we tested CD34(+) hematopoietic stem cells for the presence of natural AAV. Here, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06ed5efcf9a3ef6f6d9cd0dba0c115a
Publikováno v:
Human Gene Therapy Methods. 23:128-136
Inverted terminal repeat (ITR) integrity is critical for the replication, packaging, and transduction of recombinant adeno-associated virus (rAAV), a promising gene therapy vector. Because AAV ITRs possess 70% GC content and are palindromic, they are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff75cc35d77560a924dc207134359411
https://doi.org/10.1089/hgtb.2011.231
https://doi.org/10.1089/hgtb.2011.231
Publikováno v:
Human Gene Therapy. 18:614-626
We have previously demonstrated recombinant adeno-associated viral (rAAV) transduction of human CD34(+) hematopoietic stem cells (HSCs) capable of serial engraftment in vivo. Here we evaluated the capacity of rAAV2 to mediate gene transfer into nondi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c878208ed560689da4ac69469d66c66
https://doi.org/10.1089/hum.2006.188
https://doi.org/10.1089/hum.2006.188
Autor:
Laura Smith, Manasa Chandra, Taihra Ul-Hasan, Gregory Cost, Michael Holmes, Philip Gregory, K.K. Wong, Saswati Chatterjee
Publikováno v:
Molecular Therapy. 23
Zinc-finger nucleases (ZFN) are powerful genome editing tools that may be used to prevent expression of specified genes, correct mutations, or insert transgenes at safe harbor loci. ZFNs create double-stranded breaks at specified locations in the gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61e29af46b8747ebe41e05830372729